{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:45:08Z","timestamp":1769579108815,"version":"3.49.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:00:00Z","timestamp":1554336000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wellcome Trust Strategic Award","award":["503147"],"award-info":[{"award-number":["503147"]}]},{"name":"Wellcome Trust ISSF Seedcorn Award","award":["508353"],"award-info":[{"award-number":["508353"]}]},{"name":"Wellcome Trust Strategic Award","award":["503147"],"award-info":[{"award-number":["503147"]}]},{"name":"Wellcome Trust ISSF Seedcorn Award","award":["508353"],"award-info":[{"award-number":["508353"]}]},{"name":"S\u00ear Cymru Fellowship","award":["80762-CU-080"],"award-info":[{"award-number":["80762-CU-080"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Conceptual and computational models have been advanced that propose that perceptual disturbances in psychosis, such as hallucinations, may arise due to a disruption in the balance between bottom-up (ie sensory) and top-down (ie from higher brain areas) information streams in sensory cortex. However, the neural activity underlying this hypothesized alteration remains largely unexplored. Pharmacological N-methyl-d-aspartate receptor (NMDAR) antagonism presents an attractive model to examine potential changes as it acutely recapitulates many of the symptoms of schizophrenia including hallucinations, and NMDAR hypofunction is strongly implicated in the pathogenesis of schizophrenia as evidenced by large-scale genetic studies. Here we use in vivo 2-photon imaging to measure frontal top-down signals from the anterior cingulate cortex (ACC) and their influence on activity of the primary visual cortex (V1) in mice during pharmacologically induced NMDAR hypofunction. We find that global NMDAR hypofunction causes a significant increase in activation of top-down ACC axons, and that surprisingly this is associated with an ACC-dependent net suppression of spontaneous activity in V1 as well as a reduction in V1 sensory-evoked activity. These findings are consistent with a model in which perceptual disturbances in psychosis are caused in part by aberrant top-down frontal cortex activity that suppresses the transmission of sensory signals through early sensory areas.<\/jats:p>","DOI":"10.1093\/schbul\/sby190","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T07:11:20Z","timestamp":1547622680000},"page":"1349-1357","source":"Crossref","is-referenced-by-count":17,"title":["Top-Down Suppression of Sensory Cortex in an NMDAR Hypofunction Model of Psychosis"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4804-0832","authenticated-orcid":false,"given":"Adam","family":"Ranson","sequence":"first","affiliation":[{"name":"Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK"},{"name":"School of Medicine, Cardiff University, Cardiff, UK"},{"name":"Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eluned","family":"Broom","sequence":"additional","affiliation":[{"name":"School of Biosciences, Cardiff University, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Powell","sequence":"additional","affiliation":[{"name":"School of Psychology, Cardiff University, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangli","family":"Chen","sequence":"additional","affiliation":[{"name":"Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Major","sequence":"additional","affiliation":[{"name":"School of Biosciences, Cardiff University, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Hall","sequence":"additional","affiliation":[{"name":"Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK"},{"name":"School of Medicine, Cardiff University, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,4,3]]},"reference":[{"key":"2019102405393958500_CIT0001","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1017\/S0140525X12000477","article-title":"Whatever next? 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