{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T04:57:35Z","timestamp":1784350655741,"version":"3.55.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T00:00:00Z","timestamp":1564444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"crossref","award":["G1002190"],"award-info":[{"award-number":["G1002190"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD077482"],"award-info":[{"award-number":["HD077482"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Clinical Research Training Fellowship"},{"name":"MQ Fellows Award","award":["MQ14F40"],"award-info":[{"award-number":["MQ14F40"]}]},{"name":"British Academy Mid-Career Fellowship","award":["MD\\170005"],"award-info":[{"award-number":["MD\\170005"]}]},{"name":"National Health Service"},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Health and Social Care"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Childhood psychotic symptoms have been associated with various psychiatric disorders in adulthood but their role as early markers of poor outcomes during the crucial transition to adulthood is largely unknown. Therefore, we investigated associations between age-12 psychotic symptoms and a range of mental health problems and functional outcomes at age 18.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data were used from the Environmental Risk Longitudinal Twin Study, a nationally representative birth cohort of 2232 twins born in 1994\u20131995 in England and Wales, followed to age 18 with 93% retention. Childhood psychotic symptoms were assessed in structured interviews at age 12. At age 18, study members\u2019 mental health problems, functional outcomes, risky behaviors, and offending were measured using self-reports and official records.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Children with psychotic symptoms (N = 125, 5.9%) were more likely to experience a range of mental health problems in young adulthood than children without such symptoms. They were also more likely to be obese, smoke cigarettes, be lonely, be parents, and report a lower quality of life, but not more likely to commit crimes. Childhood psychotic symptoms predicted these poor outcomes over and above other emotional and behavioral problems during childhood. Nevertheless, twin analyses indicated that these associations were largely accounted for by shared family factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Psychotic symptoms in childhood signal risk for pervasive mental health and functional difficulties in young adulthood and thus may provide a useful screen for an array of later problems. However, early psychotic symptoms and poor outcomes may be manifestations of shared environmental and genetic risks.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/schbul\/sbz069","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T07:09:24Z","timestamp":1560928164000},"source":"Crossref","is-referenced-by-count":16,"title":["Mental Health and Functional Outcomes in Young Adulthood of Children With Psychotic Symptoms: A Longitudinal Cohort Study"],"prefix":"10.1093","author":[{"given":"Antonella","family":"Trotta","sequence":"first","affiliation":[{"name":"Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London, London UK"},{"name":"Tony Hillis Unit, Lambeth Hospital, South London and Maudsley NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Arseneault","sequence":"additional","affiliation":[{"name":"Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London, London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avshalom","family":"Caspi","sequence":"additional","affiliation":[{"name":"Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London, London UK"},{"name":"Department of Psychology and Neuroscience, Duke University, Durham, NC"},{"name":"Department of Psychiatry and Behavioral Sciences, Duke University Medical School, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrie E","family":"Moffitt","sequence":"additional","affiliation":[{"name":"Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London, London UK"},{"name":"Department of Psychology and Neuroscience, Duke University, Durham, NC"},{"name":"Department of Psychiatry and Behavioral Sciences, Duke University Medical School, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Danese","sequence":"additional","affiliation":[{"name":"Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London, London UK"},{"name":"Department of Child & Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London, London UK"},{"name":"National & Specialist CAMHS Clinic for Trauma, Anxiety and Depression, South London & Maudsley NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Pariante","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London, London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen L","family":"Fisher","sequence":"additional","affiliation":[{"name":"Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London, London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,7,30]]},"reference":[{"issue":"11","key":"2019073008201764700_CIT0001","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1001\/archpsyc.57.11.1053","article-title":"Children\u2019s self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study","volume":"57","author":"Poulton","year":"2000","journal-title":"Arch Gen Psychiatry."},{"issue":"9","key":"2019073008201764700_CIT0002","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1017\/S0033291711002960","article-title":"Prevalence of 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