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However, it is unclear whether CVA abnormalities emerge before psychotic illness onset. Understanding whether CVA manifests in clinical high-risk (CHR)\u2014compared with healthy controls and schizophrenia patients (SCZ)\u2014over time may inform our understanding of pathogenic factors. A total of 233 individuals: 73 CHR, 112 healthy controls, and 48 SCZ underwent an MRI and clinical interviews. Ninety-four individuals including healthy volunteers (HV) (n = 49) and CHR (n = 45), completed another scan at 12-months. CVA was compared by lobe in a repeated-measure design across groups, then nested by time in a longitudinal model. CHR and SCZ groups showed reduced global CVA compared with the healthy control groups but the CHR and SCZ group did not differ from each other. A group by lobe interaction indicated the presence of lobe specific reductions in frontal and cingulate CVA. Cingulate CVA was reduced in CHR and SCZ groups compared to HC groups but did not differ from each other. Frontal CVA was reduced in the older healthy controls compared with younger-HC and CHR, but did not differ from the similarly aged SZ group. CVA is similarly impacted in SCZ and CHR groups, potentially reflecting pathogenic processes. Longitudinal analyses provided further support for the neurodevelopmental hypothesis as CHR exhibited longitudinal changes in opposite directions from normative neuromaturation in HV, which was related to increasing risk for psychosis in the CHR.<\/jats:p>","DOI":"10.1093\/schbul\/sbz096","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T19:15:18Z","timestamp":1565378118000},"page":"713-721","source":"Crossref","is-referenced-by-count":14,"title":["Global and Specific Cortical Volume Asymmetries in Individuals With Psychosis Risk Syndrome and Schizophrenia: A Mixed Cross-sectional and Longitudinal Perspective"],"prefix":"10.1093","volume":"46","author":[{"given":"Katherine S F","family":"Damme","sequence":"first","affiliation":[{"name":"Department of Psychology, Northwestern University, Evanston, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Vargas","sequence":"first","affiliation":[{"name":"Department of Psychology, Northwestern University, Evanston, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vince","family":"Calhoun","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM"},{"name":"Mind Research Network, Albuquerque, NM"},{"name":"Department of Psychology, Georgia State University, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Turner","sequence":"first","affiliation":[{"name":"Mind Research Network, Albuquerque, NM"},{"name":"Department of Psychology, Georgia State University, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay A","family":"Mittal","sequence":"first","affiliation":[{"name":"Department of Psychology, Northwestern University, Evanston, IL"},{"name":"Department of Psychiatry, Northwestern University, Chicago, IL"},{"name":"Medical Social Sciences, Northwestern University, Chicago, IL"},{"name":"Institute for Policy Research (IPR), Northwestern University, Chicago, IL"},{"name":"Institute for Innovations in Developmental Sciences (DevSci), Northwestern University, Evanston, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,18]]},"reference":[{"issue":"1","key":"2020041011553896300_CIT0001","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrn1009","article-title":"Mapping brain asymmetry","volume":"4","author":"Toga","year":"2003","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"2020041011553896300_CIT0002","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/ana.410110118","article-title":"Asymmetrical volumes of the right and left frontal and occipital regions of the human brain","volume":"11","author":"Weinberger","year":"1982","journal-title":"Ann Neurol"},{"issue":"3","key":"2020041011553896300_CIT0003","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s00429-018-01818-0","article-title":"Cerebral torque is human specific and unrelated to brain size","volume":"224","author":"Xiang","year":"2019","journal-title":"Brain Struct Funct"},{"issue":"1","key":"2020041011553896300_CIT0004","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1037\/0894-4105.9.1.68","article-title":"Relations between prenatal testosterone and cerebral lateralization in children","volume":"9","author":"Grimshaw","year":"1995","journal-title":"Neuropsychology"},{"key":"2020041011553896300_CIT0005","volume-title":"Hemispheric Asymmetry: What\u2019s Right and What\u2019s Left","author":"Hellige","year":"2001"},{"key":"2020041011553896300_CIT0006","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neuroimage.2013.06.073","article-title":"Cortical thickness asymmetry from childhood to older adulthood","volume":"83","author":"Zhou","year":"2013","journal-title":"Neuroimage"},{"issue":"1","key":"2020041011553896300_CIT0007","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/oxfordjournals.schbul.a033368","article-title":"Is schizophrenia a lateralized brain disorder? 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