{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:36:56Z","timestamp":1790167016463,"version":"4.1.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003754","name":"Dr Mortimer and Theresa Sackler Foundation","doi-asserted-by":"publisher","award":["1128926"],"award-info":[{"award-number":["1128926"]}],"id":[{"id":"10.13039\/501100003754","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Metacognition is impaired in schizophrenia and is an important predictor of functional outcome, but the underlying neuropathology is not clear. Studies have implicated frontal regions and there is also some evidence that the hippocampus might play a pivotal role, but findings are inconsistent. We set out to more comprehensively investigate the neural underpinnings of insight in first-episode psychosis (FEP) using 2 metacognitive measures (the Beck Cognitive Insight Scale [BCIS]) and a perceptual metacognitive accuracy task alongside structural magnetic resonance imaging (MRI). We measured cortical thickness in insula and frontal regions, hippocampal (including subfield) volumes, hippocampal microstructure (using neurite orientation dispersion and density imaging [NODDI]), and fractional anisotropy in fornix. Relative to controls, FEP showed poorer metacognitive accuracy, thinner cortex in frontal regions and lower fornix integrity. In healthy controls (but not FEP), metacognitive accuracy correlated with cortical thickness in frontal cortex and insula. Conversely, in FEP (but not controls), metacognitive accuracy correlated with hippocampal volume and microstructural indices. Subicular hippocampal subregions were particularly implicated. No structural correlates of BCIS were found. These findings suggest that the neural bases of metacognition might differ in FEP: hippocampal (rather than frontal) integrity seems to be critical. Further, the use of objectively measured metacognitive indices seems to be a more powerful method for understanding the neurocircuitry of metacognition in FEP, which has the potential to inform therapeutic strategies and improve outcome in these patients.<\/jats:p>","DOI":"10.1093\/schbul\/sbz116","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T20:08:54Z","timestamp":1572379734000},"page":"552-561","source":"Crossref","is-referenced-by-count":31,"title":["Brain Structural Correlates of Metacognition in First-Episode Psychosis"],"prefix":"10.1093","volume":"46","author":[{"given":"Erkan","family":"Alkan","sequence":"first","affiliation":[{"name":"Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoff","family":"Davies","sequence":"first","affiliation":[{"name":"Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK"},{"name":"School of Psychology, University of Sussex, Brighton, UK"},{"name":"Surrey and Borders Partnership NHS Foundation Trust, Surrey, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Greenwood","sequence":"first","affiliation":[{"name":"School of Psychology, University of Sussex, Brighton, UK"},{"name":"Sussex Partnership NHS Foundation Trust, Worthing, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon L H","family":"Evans","sequence":"first","affiliation":[{"name":"Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,28]]},"reference":[{"issue":"10","key":"2020041011554193100_CIT0001","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1037\/0003-066X.34.10.906","article-title":"Metacognition and cognitive monitoring: a new area of cognitive\u2013developmental inquiry","volume":"34","author":"Flavell","year":"1979","journal-title":"Am Psychol."},{"issue":"9","key":"2020041011554193100_CIT0002","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1017\/S0033291710002618","article-title":"Antipsychotic treatment beyond antipsychotics: metacognitive intervention for schizophrenia patients improves delusional symptoms","volume":"41","author":"Moritz","year":"2011","journal-title":"Psychol Med."},{"key":"2020041011554193100_CIT0003","doi-asserted-by":"crossref","first-page":"341","DOI":"10.2147\/PRBM.S146446","article-title":"Metacognitive approaches to the treatment of psychosis: a comparison of four approaches","volume":"11","author":"Lysaker","year":"2018","journal-title":"Psychol Res Behav Manag"},{"key":"2020041011554193100_CIT0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/09638237.2018.1521930","article-title":"A meta-analytic review of the relationship between neurocognition, metacognition and functional outcome in schizophrenia","volume":"31","author":"Davies","year":"2018","journal-title":"J Ment Health"},{"issue":"1\u20133","key":"2020041011554193100_CIT0005","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.schres.2009.04.024","article-title":"Metacognition and schizophrenia: the capacity for self-reflectivity as a predictor for prospective assessments of work performance over six months","volume":"122","author":"Lysaker","year":"2010","journal-title":"Schizophr Res."},{"issue":"2","key":"2020041011554193100_CIT0006","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.pnpbp.2011.10.008","article-title":"Insight into illness, neurocognition and quality of life in schizophrenia","volume":"36","author":"Boyer","year":"2012","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry."},{"key":"2020041011554193100_CIT0007","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.comppsych.2016.05.008","article-title":"Metacognition moderates the relationship between dysfunctional self-appraisal and social functioning in prolonged schizophrenia independent of psychopathology","volume":"69","author":"James","year":"2016","journal-title":"Compr Psychiatry."},{"issue":"4","key":"2020041011554193100_CIT0008","first-page":"824","article-title":"Metacognition as a mediating variable between neurocognition and functional outcome in first episode psychosis","volume":"43","author":"Davies","year":"2017","journal-title":"Schizophr Bull."},{"key":"2020041011554193100_CIT0009","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3389\/fpsyt.2019.00182","article-title":"Three-year follow-up study exploring metacognition and function in individuals with first episode psychosis","volume":"10","author":"Wright","year":"2019","journal-title":"Front Psychiatry."},{"key":"2020041011554193100_CIT0010","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.3389\/fpsyg.2015.01259","article-title":"Lessons learnt? The importance of metacognition and its implications for cognitive remediation in schizophrenia","volume":"6","author":"Cella","year":"2015","journal-title":"Front Psychol."},{"issue":"4","key":"2020041011554193100_CIT0011","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/cpp.362","article-title":"How to evaluate metacognitive functioning in psychotherapy? The metacognition assessment scale and its applications","volume":"10","author":"Semerari","year":"2003","journal-title":"Clin Psychol Psychot."},{"issue":"1","key":"2020041011554193100_CIT0012","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1600-0447.2005.00514.x","article-title":"Metacognition amidst narratives of self and illness in schizophrenia: associations with neurocognition, symptoms, insight and quality of life","volume":"112","author":"Lysaker","year":"2005","journal-title":"Acta Psychiatr Scand."},{"issue":"2-3","key":"2020041011554193100_CIT0013","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0920-9964(03)00189-0","article-title":"A new instrument for measuring insight: the beck cognitive insight scale","volume":"68","author":"Beck","year":"2004","journal-title":"Schizophr Res."},{"key":"2020041011554193100_CIT0014","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.schres.2017.06.048","article-title":"A longitudinal study of cognitive insight and cortical thickness in first-episode psychosis","volume":"193","author":"Buchy","year":"2018","journal-title":"Schizophr Res."},{"issue":"4","key":"2020041011554193100_CIT0015","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/scan\/nss016","article-title":"The neuroanatomical correlates of cognitive insight in schizophrenia","volume":"8","author":"Orfei","year":"2013","journal-title":"Soc Cogn Affect Neurosci."},{"issue":"6","key":"2020041011554193100_CIT0016","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1176\/ajp.150.6.873","article-title":"Assessment of insight in psychosis","volume":"150","author":"Amador","year":"1993","journal-title":"Am J Psychiatry"},{"issue":"1","key":"2020041011554193100_CIT0017","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/schbul\/sbq100","article-title":"Domains of awareness in schizophrenia","volume":"37","author":"Gilleen","year":"2011","journal-title":"Schizophr Bull."},{"issue":"1","key":"2020041011554193100_CIT0018","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12888-017-1210-9","article-title":"Can cognitive insight predict symptom remission in a first episode psychosis cohort?","volume":"17","author":"O\u2019Connor","year":"2017","journal-title":"BMC Psychiatry."},{"key":"2020041011554193100_CIT0019","doi-asserted-by":"crossref","first-page":"6371856","DOI":"10.1155\/2016\/6371856","article-title":"Does the beck cognitive insight scale predict response to cognitive remediation in schizophrenia?","volume":"2016","author":"Benoit","year":"2016","journal-title":"Schizophr Res Treatment"},{"key":"2020041011554193100_CIT0020","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1093\/schbul\/sbx021.277","article-title":"199. Disrupted integration in early psychosis: a preliminary exploration of the relationship between neural synchronization and higher order cognition in a first-episode psychosis sample","volume":"43","author":"Leonhardt","year":"2017","journal-title":"Schizophr Bull."},{"key":"2020041011554193100_CIT0021","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.pscychresns.2016.12.014","article-title":"Association of medial prefrontal resting state functional connectivity and metacognitive capacity in early phase psychosis","volume":"262","author":"Francis","year":"2017","journal-title":"Psychiatry Res Neuroimaging"},{"issue":"7","key":"2020041011554193100_CIT0022","doi-asserted-by":"crossref","first-page":"14640","DOI":"10.3390\/ijms160714640","article-title":"Metacognition in early phase psychosis: toward understanding neural substrates","volume":"16","author":"Vohs","year":"2015","journal-title":"Int J Mol Sci."},{"issue":"1\u20133","key":"2020041011554193100_CIT0023","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.schres.2016.02.026","article-title":"Cognitive insight is associated with cortical thickness in first-episode psychosis","volume":"172","author":"Buchy","year":"2016","journal-title":"Schizophr Res."},{"key":"2020041011554193100_CIT0024","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.schres.2016.09.036","article-title":"A pilot study of cognitive insight and structural covariance in first-episode psychosis","volume":"179","author":"Kuang","year":"2017","journal-title":"Schizophr Res."},{"issue":"5","key":"2020041011554193100_CIT0025","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1093\/schbul\/sbp015","article-title":"Toward a model of cognitive insight in first-episode psychosis: verbal memory and hippocampal structure","volume":"36","author":"Buchy","year":"2010","journal-title":"Schizophr Bull."},{"key":"2020041011554193100_CIT0026","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cortex.2016.10.017","article-title":"Unrealistic self-overconfidence in schizophrenia is associated with left presubiculum atrophy and impaired episodic memory","volume":"86","author":"Orfei","year":"2017","journal-title":"Cortex."},{"issue":"1-3","key":"2020041011554193100_CIT0027","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.schres.2012.02.015","article-title":"Diffusion tensor imaging tractography of the fornix and belief confidence in first-episode psychosis","volume":"137","author":"Buchy","year":"2012","journal-title":"Schizophr Res."},{"issue":"4","key":"2020041011554193100_CIT0028","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.neuroimage.2012.03.072","article-title":"NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain","volume":"61","author":"Zhang","year":"2012","journal-title":"Neuroimage."},{"key":"2020041011554193100_CIT0029","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.neuroimage.2018.02.017","article-title":"Neurite imaging reveals microstructural variations in human cerebral cortical gray matter","volume":"182","author":"Fukutomi","year":"2018","journal-title":"Neuroimage."},{"issue":"10","key":"2020041011554193100_CIT0030","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.biopsych.2016.12.005","article-title":"Gray matter neuritic microstructure deficits in schizophrenia and bipolar disorder","volume":"82","author":"Nazeri","year":"2017","journal-title":"Biol Psychiatry."},{"issue":"10","key":"2020041011554193100_CIT0031","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.biopsych.2017.02.008","article-title":"Deficits in neurite density underlie white matter structure abnormalities in first-episode psychosis","volume":"82","author":"Rae","year":"2017","journal-title":"Biol Psychiatry."},{"issue":"5998","key":"2020041011554193100_CIT0032","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1126\/science.1191883","article-title":"Relating introspective accuracy to individual differences in brain structure","volume":"329","author":"Fleming","year":"2010","journal-title":"Science."},{"issue":"1594","key":"2020041011554193100_CIT0033","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1098\/rstb.2011.0417","article-title":"The neural basis of metacognitive ability","volume":"367","author":"Fleming","year":"2012","journal-title":"Philos Trans R Soc Lond B Biol Sci."},{"issue":"8","key":"2020041011554193100_CIT0034","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1162\/jocn_a_00233","article-title":"A meta-analysis of functional neuroimaging studies of self- and other judgments reveals a spatial gradient for mentalizing in medial prefrontal cortex","volume":"24","author":"Denny","year":"2012","journal-title":"J Cogn Neurosci."},{"issue":"3","key":"2020041011554193100_CIT0035","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/13546805.2018.1444597","article-title":"Impairment of perceptual metacognitive accuracy and reduced prefrontal grey matter volume in first-episode psychosis","volume":"23","author":"Davies","year":"2018","journal-title":"Cogn Neuropsychiatry."},{"issue":"10","key":"2020041011554193100_CIT0036","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1017\/S0033291716000684","article-title":"Cortical thickness and surface area correlates with cognitive dysfunction among first-episode psychosis patients","volume":"46","author":"Haring","year":"2016","journal-title":"Psychol Med."},{"issue":"5","key":"2020041011554193100_CIT0037","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1001\/archgenpsychiatry.2009.24","article-title":"Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability","volume":"66","author":"Goldman","year":"2009","journal-title":"Arch Gen Psychiatry."},{"issue":"6","key":"2020041011554193100_CIT0038","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.biopsych.2011.11.026","article-title":"Cortical volume, surface area, and thickness in schizophrenia and bipolar disorder","volume":"71","author":"Rimol","year":"2012","journal-title":"Biol Psychiatry."},{"issue":"2","key":"2020041011554193100_CIT0039","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.comppsych.2013.08.027","article-title":"Metacognition, symptoms and premorbid functioning in a first episode psychosis sample","volume":"55","author":"Macbeth","year":"2014","journal-title":"Compr Psychiatry."},{"issue":"1","key":"2020041011554193100_CIT0040","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/papt.12059","article-title":"Metacognitive training for young subjects (MCT young version) in the early stages of psychosis: is the duration of untreated psychosis a limiting factor?","volume":"89","author":"Ussorio","year":"2016","journal-title":"Psychol Psychother."},{"issue":"2","key":"2020041011554193100_CIT0041","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The positive and negative syndrome scale (PANSS) for schizophrenia","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophr Bull."},{"issue":"1","key":"2020041011554193100_CIT0042","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.concog.2011.09.021","article-title":"A signal detection theoretic approach for estimating metacognitive sensitivity from confidence ratings","volume":"21","author":"Maniscalco","year":"2012","journal-title":"Conscious Cogn."},{"issue":"4","key":"2020041011554193100_CIT0043","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1037\/a0033268","article-title":"Measures of metacognition on signal-detection theoretic models","volume":"18","author":"Barrett","year":"2013","journal-title":"Psychol Methods."},{"key":"2020041011554193100_CIT0044","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.concog.2014.06.007","article-title":"Effects of age on metacognitive efficiency","volume":"28","author":"Palmer","year":"2014","journal-title":"Conscious Cogn."},{"issue":"3","key":"2020041011554193100_CIT0045","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/bmsp.12069","article-title":"Comparing dependent robust correlations","volume":"69","author":"Wilcox","year":"2016","journal-title":"Br J Math Stat Psychol."},{"key":"2020041011554193100_CIT0046","doi-asserted-by":"crossref","first-page":"8 42 41","DOI":"10.1002\/cpns.41","article-title":"A guide to robust statistical methods in neuroscience","volume":"82","author":"Wilcox","year":"2018","journal-title":"Curr Protoc Neurosci."},{"issue":"1","key":"2020041011554193100_CIT0047","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/schbul\/sbt177","article-title":"Altered cortical thickness related to clinical severity but not the untreated disease duration in schizophrenia","volume":"41","author":"Xiao","year":"2015","journal-title":"Schizophr Bull."},{"issue":"10","key":"2020041011554193100_CIT0048","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1038\/npp.2016.84","article-title":"Glutamatergic metabolites, volume and cortical thickness in antipsychotic-naive patients with first-episode psychosis: implications for excitotoxicity","volume":"41","author":"Plitman","year":"2016","journal-title":"Neuropsychopharmacology."},{"issue":"5","key":"2020041011554193100_CIT0049","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.eurpsy.2008.02.003","article-title":"Cognitive insight and verbal memory in first episode of psychosis","volume":"23","author":"Lepage","year":"2008","journal-title":"Eur Psychiatry."},{"issue":"2","key":"2020041011554193100_CIT0050","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.psychres.2009.05.009","article-title":"Cognitive insight in psychosis: the relationship between self-certainty and self-reflection dimensions and neuropsychological measures","volume":"178","author":"Cooke","year":"2010","journal-title":"Psychiatry Res."},{"issue":"3","key":"2020041011554193100_CIT0051","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/schbul\/sbx108","article-title":"Hippocampal subfield volumes in patients with first-episode psychosis","volume":"44","author":"Baglivo","year":"2018","journal-title":"Schizophr Bull."},{"issue":"1","key":"2020041011554193100_CIT0052","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neuron.2013.02.011","article-title":"Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver","volume":"78","author":"Schobel","year":"2013","journal-title":"Neuron."},{"issue":"8","key":"2020041011554193100_CIT0053","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1038\/mp.2017.249","article-title":"Hippocampal dysfunction in the pathophysiology of schizophrenia: a selective review and hypothesis for early detection and intervention","volume":"23","author":"Lieberman","year":"2018","journal-title":"Mol Psychiatry."},{"issue":"4","key":"2020041011554193100_CIT0054","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/npr2.12031","article-title":"Hippocampal subregion abnormalities in schizophrenia: a systematic review of structural and physiological imaging studies","volume":"38","author":"Nakahara","year":"2018","journal-title":"Neuropsychopharmacol Rep."},{"issue":"5","key":"2020041011554193100_CIT0055","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.neuron.2005.05.002","article-title":"The hippocampal-VTA loop: controlling the entry of information into long-term memory","volume":"46","author":"Lisman","year":"2005","journal-title":"Neuron."},{"issue":"2","key":"2020041011554193100_CIT0056","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.schres.2014.04.022","article-title":"Diffusion tensor imaging study of the fornix in first episode schizophrenia and in healthy controls","volume":"156","author":"Fitzsimmons","year":"2014","journal-title":"Schizophr Res."},{"issue":"4","key":"2020041011554193100_CIT0057","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1001\/archpsyc.57.4.349","article-title":"Structural abnormalities of subicular dendrites in subjects with schizophrenia and mood disorders: preliminary findings","volume":"57","author":"Rosoklija","year":"2000","journal-title":"Arch Gen Psychiatry."},{"issue":"1","key":"2020041011554193100_CIT0058","first-page":"54","article-title":"Metacognition in schizophrenia spectrum disorders: methods of assessment and associations with neurocognition, symptoms, cognitive style and function","volume":"51","author":"Lysaker","year":"2014","journal-title":"Isr J Psychiatry Relat Sci."},{"issue":"1","key":"2020041011554193100_CIT0059","first-page":"40","article-title":"First episode psychosis and ethnicity: initial findings from the AESOP study","volume":"5","author":"Morgan","year":"2006","journal-title":"World Psychiatry"},{"issue":"2","key":"2020041011554193100_CIT0060","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1192\/bjpo.bp.115.002444","article-title":"The effect of second-generation antipsychotics on hippocampal volume in first episode of psychosis: longitudinal study","volume":"2","author":"Bodnar","year":"2016","journal-title":"BJPsych Open"},{"issue":"1","key":"2020041011554193100_CIT0061","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12888-018-1667-1","article-title":"Computer-assisted cognitive remediation therapy increases hippocampal volume in patients with schizophrenia: a randomized controlled trial","volume":"18","author":"Morimoto","year":"2018","journal-title":"BMC Psychiatry"},{"issue":"6","key":"2020041011554193100_CIT0062","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1093\/schbul\/sbx168","article-title":"The effects of metacognition-oriented social skills training on psychosocial outcome in schizophrenia-spectrum disorders: a randomized controlled trial","volume":"44","author":"Inchausti","year":"2018","journal-title":"Schizophr Bull."}],"container-title":["Schizophrenia Bulletin"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/schizophreniabulletin\/article-pdf\/46\/3\/552\/33033379\/sbz116.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/schizophreniabulletin\/article-pdf\/46\/3\/552\/33033379\/sbz116.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T16:47:29Z","timestamp":1586537249000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/schizophreniabulletin\/article\/46\/3\/552\/5644634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,28]]},"references-count":62,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,11,28]]},"published-print":{"date-parts":[[2020,4,10]]}},"URL":"https:\/\/doi.org\/10.1093\/schbul\/sbz116","relation":{},"ISSN":["0586-7614","1745-1701"],"issn-type":[{"value":"0586-7614","type":"print"},{"value":"1745-1701","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,5]]},"published":{"date-parts":[[2019,11,28]]}}}