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Current models of symptom development assume that basic symptoms develop first, followed by attenuated and, finally, frank psychotic symptoms, though interrelations of these symptoms are yet unknown. Therefore, we studied for the first time their interrelations using a network approach in 460 patients of an early detection service (mean age\u2005=\u200526.3 y, SD\u2005=\u20056.4; 65% male; n\u2005=\u2005203 clinical high-risk [CHR], n\u2005=\u2005153 first-episode psychosis, and n\u2005=\u2005104 depression). Basic, attenuated, and frank psychotic symptoms were assessed using the Schizophrenia Proneness Instrument, Adult version (SPI-A), the Structured Interview for Psychosis-Risk Syndromes (SIPS), and the Positive And Negative Syndrome Scale (PANSS). Using the R package qgraph, network analysis of the altogether 86 symptoms revealed a single dense network of highly interrelated symptoms with 5 discernible symptom subgroups. Disorganized communication was the most central symptom, followed by delusions and hallucinations. In line with current models of symptom development, the network was distinguished by symptom severity running from SPI-A via SIPS to PANSS assessments. This suggests that positive symptoms developed from cognitive and perceptual disturbances included basic symptom criteria. Possibly conveying important insight for clinical practice, central symptoms, and symptoms \u201cbridging\u201d the association between symptom subgroups may be regarded as the main treatment targets, in order to prevent symptomatology from spreading or increasing across the whole network.<\/jats:p>","DOI":"10.1093\/schbul\/sbz140","type":"journal-article","created":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T12:07:45Z","timestamp":1577966865000},"page":"884-895","source":"Crossref","is-referenced-by-count":37,"title":["Main Symptomatic Treatment Targets in Suspected and Early Psychosis: New Insights From Network Analysis"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9618-3424","authenticated-orcid":false,"given":"Natalia","family":"Jimeno","sequence":"first","affiliation":[{"name":"Department of Psychiatry, School of Medicine University of Valladolid, Valladolid, Spain"},{"name":"Department of Psychiatry and Psychotherapy, Medical Faculty Heinrich-Heine University, D\u00fcsseldorf, Germany"},{"name":"GINCS, Research Group on Clinical Neuroscience of Segovia, Segovia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7882-7890","authenticated-orcid":false,"given":"Javier","family":"Gomez-Pilar","sequence":"first","affiliation":[{"name":"Biomedical Engineering Group, University of Valladolid, Valladolid, Spain"},{"name":"CIBER-BBN, Centro de Investigacion Biomedica en Red-Bioingenieria, Biomateriales y Biomedicina, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Poza","sequence":"first","affiliation":[{"name":"Biomedical Engineering Group, University of Valladolid, Valladolid, Spain"},{"name":"CIBER-BBN, Centro de Investigacion Biomedica en Red-Bioingenieria, Biomateriales y Biomedicina, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Hornero","sequence":"first","affiliation":[{"name":"Biomedical Engineering Group, University of Valladolid, Valladolid, Spain"},{"name":"CIBER-BBN, Centro de Investigacion Biomedica en Red-Bioingenieria, Biomateriales y Biomedicina, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Vogeley","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine and University Hospital Cologne University of Cologne, Cologne, Germany"},{"name":"INM3, Institute of Neuroscience and Medicine, Research Center J\u00fclich, J\u00fclich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Meisenzahl","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical Faculty Heinrich-Heine University, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Haidl","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine and University Hospital Cologne University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Rosen","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine and University Hospital Cologne University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Klosterk\u00f6tter","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine and University Hospital Cologne University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke","family":"Schultze-Lutter","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical Faculty Heinrich-Heine University, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,3]]},"reference":[{"issue":"4","key":"2020070810443171300_CIT0001","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/schbul\/sbs060","article-title":"At risk for schizophrenic or affective psychoses? 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