{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:59:37Z","timestamp":1789415977527,"version":"build-2803163510"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Shiitake mushroom dermatitis is a well-documented phenomenon in the literature seen after consuming raw or undercooked shiitake mushrooms (Lentinus edodes). However, systemic features resembling a drug reaction with eosinophilia and systemic symptoms (DRESS) are rare. We report a case of severe shiitake mushroom dermatitis with atypical systemic features resembling DRESS. A 51-year-old man presented with acute unilateral periorbital oedema and flagellate erythema with no obvious drug precipitants and was initially managed as allergic contact dermatitis in the emergency department. Further inquiry revealed a history of raw shiitake mushroom ingestion 48 h before the onset of symptoms, which led to a working diagnosis of shiitake mushroom dermatitis. Skin biopsies showed mixed spongiotic and interface inflammatory reactions with a perivascular lymphocytic infiltrate and marked eosinophilia supportive of shiitake mushroom dermatitis. Rheumatological causes of flagellate erythema and periorbital oedema were excluded from clinical and laboratory findings. The patient initially presented with apyrexia and mild eosinophilia but then developed pyrexia, hypereosinophilia, neutrophilia and transaminitis. He subsequently developed bilateral periorbital oedema with his flagellate erythema, both of which were resolved with topical and oral corticosteroids. However, there was a new widespread morbilliform eruption with dorsal oedema of his hands. A diagnosis of DRESS-like shiitake mushroom dermatitis was considered. The patient required a long course of oral prednisolone to achieve clinical and biochemical resolution of his symptoms. Our case underscores the importance of prompt recognition and management of shiitake dermatitis, especially when it presents with DRESS-like features.<\/jats:p>","DOI":"10.1093\/skinhd\/vzae012","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T10:54:46Z","timestamp":1737370486000},"page":"56-60","source":"Crossref","is-referenced-by-count":3,"title":["An unusually severe case of shiitake mushroom dermatitis with features of drug reaction with eosinophilia and systemic symptoms"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0750-4522","authenticated-orcid":false,"given":"Tristen Tze Wei","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Dermatology, Royal Perth Hospital , Perth, WA ,","place":["Australia"]},{"name":"UWA Medical School, The University of Western Australia , Crawley, WA ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin Andrew","family":"Wood","sequence":"additional","affiliation":[{"name":"UWA Medical School, The University of Western Australia , Crawley, WA ,","place":["Australia"]},{"name":"Department of Dermatopathology, PathWest Laboratory Medicine , Nedlands, WA ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Royal Perth Hospital , Perth, WA ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"2025031806235578300_vzae012-B1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.tifs.2023.03.007","article-title":"Therapeutic values and nutraceutical properties of shiitake mushroom (Lentinula edodes): a review","volume":"134","author":"Ahmad","year":"2023","journal-title":"Trends Food Sci Technol"},{"key":"2025031806235578300_vzae012-B2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1600-0536.1992.tb05211.x","article-title":"Shiitake (Lentinus edodes) dermatitis","volume":"27","author":"Nakamura","year":"1992","journal-title":"Contact Dermatitis"},{"key":"2025031806235578300_vzae012-B3","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/ijd.13433","article-title":"Clinical features of shiitake dermatitis: a systematic review","volume":"56","author":"Nguyen","year":"2017","journal-title":"Int J Dermatol"},{"key":"2025031806235578300_vzae012-B4","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1684\/ejd.2020.3777","article-title":"Shiitake dermatitis: a type IV allergic hypersensitivity reaction to raw mushrooms","volume":"30","author":"Albuscheit","year":"2020","journal-title":"Eur J Dermatol"},{"key":"2025031806235578300_vzae012-B5","doi-asserted-by":"crossref","first-page":"e140","DOI":"10.1016\/j.jaad.2011.11.926","article-title":"Clinical variability of shiitake dermatitis","volume":"67","author":"Adler","year":"2012","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"2025031806235578300_vzae012-B6","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/DAD.0000000000001271","article-title":"Histological features of flagellate erythema","volume":"41","author":"Ching","year":"2019","journal-title":"Am J Dermatopathol"},{"key":"2025031806235578300_vzae012-B7","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.3390\/ijms18061243","article-title":"Drug reaction with eosinophilia and systemic symptoms (DRESS): an interplay among drugs, viruses, and immune system","volume":"18","author":"Cho","year":"2017","journal-title":"Int J Mol Sci"},{"key":"2025031806235578300_vzae012-B8","doi-asserted-by":"crossref","first-page":"100673","DOI":"10.1016\/j.waojou.2022.100673","article-title":"DRESS syndrome: a literature review and treatment algorithm","volume":"16","author":"Calle","year":"2023","journal-title":"World Allergy Organ J"},{"key":"2025031806235578300_vzae012-B9","first-page":"440","article-title":"Shiitake dermatitis in Korea; clinical and histopathologic study","volume":"41","author":"Ha","year":"2003","journal-title":"Korean J Dermatol"},{"key":"2025031806235578300_vzae012-B10","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1016\/j.mayocp.2022.07.017","article-title":"Shiitake flagellate dermatitis","volume":"97","author":"Ma","year":"2022","journal-title":"Mayo Clin Proc"},{"key":"2025031806235578300_vzae012-B11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jdcr.2015.02.010","article-title":"Pustular flagellate dermatitis after consumption of shiitake mushrooms","volume":"1","author":"Netchiporouk","year":"2015","journal-title":"JAAD Case Rep"},{"key":"2025031806235578300_vzae012-B12","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/ced.12500","article-title":"Shiitake dermatitis with oral ulceration and pustules","volume":"40","author":"Hamer","year":"2015","journal-title":"Clin Exp Dermatol"},{"key":"2025031806235578300_vzae012-B13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1001\/jamadermatol.2023.4450","article-title":"Management of adult patients with drug reaction with eosinophilia and systemic symptoms: a Delphi-based international consensus","volume":"160","author":"Br\u00fcggen","year":"2024","journal-title":"JAMA Dermatol"},{"key":"2025031806235578300_vzae012-B14","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/jdv.18808","article-title":"Management and treatment outcome of DRESS patients in Europe: an international multicentre retrospective study of 141 cases","volume":"37","author":"Kridin","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025031806235578300_vzae012-B15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000018007","article-title":"Flagellate mushroom (shiitake) dermatitis and photosensitivity","volume":"197","author":"Hanada","year":"1998","journal-title":"Dermatology"},{"key":"2025031806235578300_vzae012-B16","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0091-6749(98)70168-X","article-title":"Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms","volume":"101","author":"Levy","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"2025031806235578300_vzae012-B17","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1684\/ejd.2011.1398","article-title":"DRESS-like syndrome induced by shiitake mushroom","volume":"21","author":"Talour","year":"2011","journal-title":"Eur J Dermatol"}],"container-title":["Skin Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/5\/1\/56\/61516207\/vzae012.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/5\/1\/56\/61516207\/vzae012.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T06:24:58Z","timestamp":1742279098000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/skinhd\/article\/5\/1\/56\/7964335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,20]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3,18]]}},"URL":"https:\/\/doi.org\/10.1093\/skinhd\/vzae012","relation":{},"ISSN":["2690-442X"],"issn-type":[{"value":"2690-442X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,2]]},"published":{"date-parts":[[2025,1,20]]}}}