{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:08:26Z","timestamp":1780340906715,"version":"3.54.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cogan syndrome (CS) is a rare autoimmune vasculitis affecting the audiovestibular and ocular systems. Its pathogenesis is unknown. CS was classified into typical and atypical CS in 1980 to aid its diagnosis. Its association with pyoderma gangrenosum (PG) has only been reported three times in the literature. This is also the first case of its occurrence in a person with skin of colour. CS is a diagnosis of exclusion and thus its diagnosis may present many challenges to healthcare professionals. Herein, we describe the case of a 75-year-old South Asian woman who presented acutely to the Stroke Unit following a right lacunar infarction which was treated with aspirin and clopidogrel. An enlarging nonhealing wound was noted at the site of a recent total left hip replacement. Intravenous antibiotics were started, with multiple surgical debridements performed. During admission, two new painful pustular skin lesions erupted on the chest and abdomen that ulcerated within 2 days. Painful ulcerated lesions with bluish undermined edges were also noted at the left hip wound and two pressure areas of the buttocks. A\u00a0clinical diagnosis of PG was made and treatment was started with high-dose corticosteroids, which did not lead to improvement. The patient\u2019s past medical history included left eye central retinal vein occlusion with recurrent uveitis and bilateral sensorineural deafness. A diagnosis of atypical CS was made. Four pulsed cyclophosphamide infusions and hyperbaric oxygen healed the lesions. This case demonstrates the complex interplay between PG and CS, which requires further research as it can result in significant morbidity.<\/jats:p>","DOI":"10.1093\/skinhd\/vzae027","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T20:18:41Z","timestamp":1735849121000},"page":"79-81","source":"Crossref","is-referenced-by-count":1,"title":["A rare case of aggressive pyoderma gangrenosum with Cogan syndrome in a person with skin of colour"],"prefix":"10.1093","volume":"5","author":[{"given":"Nageswary","family":"Nadarajah","sequence":"first","affiliation":[{"name":"Department of Medicine, Hull University Teaching Hospitals NHS Foundation Trust , Hull ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Clark","sequence":"additional","affiliation":[{"name":"University of Hull, Northern Lincolnshire and Goole NHS Trust , Scunthorpe ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1018-1320","authenticated-orcid":false,"given":"Shernaz","family":"Walton","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Hull, Hull University Teaching Hospitals NHS Foundation Trust , Hull ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"2025031806220972300_vzae027-B1","article-title":"Cogan\u2019s syndrome with pyoderma gangrenosum: management of two uncommon disorders with aggressive presentation in a patient","volume":"2018","author":"Chua","year":"2018","journal-title":"BMJ Case Rep"},{"key":"2025031806220972300_vzae027-B2","first-page":"6","article-title":"Cogan\u2019s syndrome","volume":"59","author":"Iliescu","year":"2015","journal-title":"Rom J Ophthalmol"},{"key":"2025031806220972300_vzae027-B3","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/00005792-198011000-00003","article-title":"Cogan syndrome: studies in thirteen patients, long-term follow-up, and a review of the literature","volume":"59","author":"Haynes","year":"1980","journal-title":"Medicine (Baltimore)"},{"key":"2025031806220972300_vzae027-B4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ad.2016.10.017","article-title":"Atypical ulcerated lesions in a patient with Cogan syndrome","volume":"108","author":"Solano-L\u00f3pez","year":"2017","journal-title":"Actas Dermosifiliogr"},{"key":"2025031806220972300_vzae027-B5","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1046\/j.1365-2230.1998.00390.x","article-title":"Pyoderma gangrenosum complicating Cogan\u2019s syndrome","volume":"23","author":"Boulinguez","year":"1998","journal-title":"Clin Exp Dermatol"},{"key":"2025031806220972300_vzae027-B6","doi-asserted-by":"crossref","first-page":"670","DOI":"10.7326\/0003-4819-150-10-200905190-00004","article-title":"Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized trial","volume":"150","author":"De Groot","year":"2009","journal-title":"Ann Intern Med"},{"key":"2025031806220972300_vzae027-B7","doi-asserted-by":"crossref","first-page":"h2958","DOI":"10.1136\/bmj.h2958","article-title":"Comparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial","volume":"350","author":"Ormerod","year":"2015","journal-title":"Br Med J"}],"container-title":["Skin Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/5\/1\/79\/61898287\/vzae027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/5\/1\/79\/61898287\/vzae027.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T06:22:19Z","timestamp":1742278939000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/skinhd\/article\/5\/1\/79\/8015509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3,18]]}},"URL":"https:\/\/doi.org\/10.1093\/skinhd\/vzae027","relation":{},"ISSN":["2690-442X"],"issn-type":[{"value":"2690-442X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,2]]},"published":{"date-parts":[[2025,2]]}}}