{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:48:06Z","timestamp":1793119686264,"version":"4.5.0"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Purpuric drug eruption (PDE) is a rare drug reaction characterized by purpuric macules, papules and confluent plaques predominantly on the lower extremities. The drugs reported to induce PDE are epidermal growth factor receptor inhibitors, ketoconazole, acetylsalicylic acid, penicillin, sulfonamides, indomethacin, lenalidomide, linezolid and vancomycin. Drug-induced thrombocytopenia, platelet dysfunction and direct toxic effects of the drug on the capillary wall leading to increased capillary fragility are the proposed aetiologies. There is only a single report of itraconazole-induced PDE in the literature to date. We herein present a case of 57-year-old woman with PDE due to itraconazole.<\/jats:p>","DOI":"10.1093\/skinhd\/vzaf006","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T07:12:58Z","timestamp":1737184378000},"page":"148-150","source":"Crossref","is-referenced-by-count":2,"title":["Itraconazole-associated purpuric drug eruption: a rare adverse effect of a commonly prescribed drug"],"prefix":"10.1093","volume":"5","author":[{"given":"Mahesh","family":"Mathur","sequence":"first","affiliation":[{"name":"Department of Dermatology, College of Medical Sciences Teaching Hospital , Bharatpur ,","place":["Nepal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5844-8910","authenticated-orcid":false,"given":"Sandhya","family":"Regmi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medical Sciences Teaching Hospital , Bharatpur 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College of Medical Sciences Teaching Hospital , Bharatpur ,","place":["Nepal"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"2025051214221911300_vzaf006-B1","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1001\/jamadermatol.2017.0903","article-title":"Purpuric drug eruptions caused by epidermal growth factor receptor inhibitors for non-small cell lung cancer: a clinicopathologic study of 32 cases","volume":"153","author":"Cho","year":"2017","journal-title":"JAMA Dermatol"},{"key":"2025051214221911300_vzaf006-B2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4103\/idoj.IDOJ_353_18","article-title":"Oral antifungal therapy: emerging culprits of cutaneous adverse drug reactions","volume":"10","author":"Chaudhary","year":"2019","journal-title":"Indian Dermatol Online 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unreported side effect of itraconazole","volume":"17","author":"Mistry","year":"2022","journal-title":"Indian J Rheumatol"},{"key":"2025051214221911300_vzaf006-B7","doi-asserted-by":"crossref","first-page":"501","DOI":"10.4103\/idoj.IDOJ_179_17","article-title":"Symmetric drug-\u00adrelated intertriginous and flexural exanthema due to itraconazole: an uncommon side effect of a commonly used drug","volume":"8","author":"Mohapatra","year":"2017","journal-title":"Indian Dermatol Online J"}],"container-title":["Skin Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/5\/2\/148\/62518366\/vzaf006.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/5\/2\/148\/62518366\/vzaf006.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T14:22:27Z","timestamp":1747059747000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/skinhd\/article\/5\/2\/148\/8089844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,5,12]]}},"URL":"https:\/\/doi.org\/10.1093\/skinhd\/vzaf006","relation":{},"ISSN":["2690-442X"],"issn-type":[{"value":"2690-442X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2025,3,21]]}}}