{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:37:46Z","timestamp":1792291066799,"version":"4.4.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Androgenetic alopecia (AGA) is a very common cause of noncicatricial alopecia, which negatively affects a person\u2019s wellbeing. Although Food and Drug Administration (FDA)-approved drugs such as topical minoxidil result in an apparent improvement in this hair condition in a period of 4\u20136 months and have been used commonly as the first-line treatment of choice, another treatment modality that has gained popularity over the years is platelet-rich plasma (PRP) therapy. PRP is minimally invasive but much more cost-effective than restoration surgery. The FDA has not approved PRP as a treatment modality for AGA. We systematically reviewed the existing literature from Embase, Web of Science, CENTRAL and PubMed from inception to 2024, and included six clinical trials that compared these two commonly practised dermatological therapies for the treatment of AGA. Most studies used global photographic assessment of hair changes based on the investigator\u2019s examination, which demonstrated statistically significant changes in hair density, terminal hair count and hair pull test. A few studies used subjective quantitative measures of hair parameters, such as patient satisfaction scores and improvement in hair quality. Topical minoxidil showed more improvement in terminal hair count and proportion of anagen hair. PRP showed more improvement in hair density and a negative hair pull test. All of the selected studies suggested that the efficacy of PRP is nearly comparable to that of topical minoxidil, with minimal adverse effects on long-term follow-up. Thus, PRP is a valuable treatment option either adjuvant to topical minoxidil or as a second-line treatment option for AGA.<\/jats:p>","DOI":"10.1093\/skinhd\/vzaf040","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T17:30:55Z","timestamp":1753291855000},"page":"311-318","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of the efficacy of platelet-rich plasma with topical minoxidil in treating patients with androgenetic alopecia: a\u00a0systematic review of clinical trials"],"prefix":"10.1093","volume":"5","author":[{"given":"Areesha","family":"Abid","sequence":"first","affiliation":[{"name":"Department of Medicine, Rawalpindi Medical University , Rawalpindi ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2091-2088","authenticated-orcid":false,"given":"Faizan","family":"Fazal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rawalpindi Medical University , Rawalpindi ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haris","family":"Mumtaz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rawalpindi Medical University , Rawalpindi ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafsa Arshad Azam","family":"Raja","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rawalpindi Medical University , Rawalpindi ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal Haider","family":"Malik","sequence":"additional","affiliation":[{"name":"ST6 Dermatology, Department of Dermatology, Betsi Cadwaladr University Health Board , Wrexham Maelor Hospital, Wrexham ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"2025093003014306700_vzaf040-B1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/jocd.14983","article-title":"The psychological consequences of androgenetic alopecia: a systematic review","volume":"22","author":"Aukerman","year":"2023","journal-title":"J Cosmet Dermatol"},{"key":"2025093003014306700_vzaf040-B2","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1111\/bjd.17463","article-title":"Living with alopecia areata: an online qualitative survey study","volume":"180","author":"Davey","year":"2019","journal-title":"Br J Dermatol"},{"key":"2025093003014306700_vzaf040-B3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jdin.2023.07.005","article-title":"Androgenetic alopecia: an update","volume":"13","author":"Ntshingila","year":"2023","journal-title":"JAAD Int"},{"key":"2025093003014306700_vzaf040-B4","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ijwd.2018.08.004","article-title":"Platelet-rich plasma for androgenetic alopecia: a review of the literature and proposed treatment protocol","volume":"5","author":"Stevens","year":"2019","journal-title":"Int J Womens Dermatol"},{"key":"2025093003014306700_vzaf040-B5","volume-title":"Minoxidil. StatPearls","author":"Patel","year":"2024"},{"key":"2025093003014306700_vzaf040-B6","doi-asserted-by":"crossref","first-page":"635","DOI":"10.2147\/DDDT.S356858","article-title":"Platelet rich plasma and its use in hair regrowth: a review","volume":"16","author":"Paichitrojjana","year":"2022","journal-title":"Drug Des Devel Ther"},{"key":"2025093003014306700_vzaf040-B7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.29271\/jcpsp.2024.01.11","article-title":"Efficacy of platelet-rich plasma versus 5% topical minoxidil for the treatment of androgenetic alopecia","volume":"34","author":"Afzal","year":"2024","journal-title":"J Coll Physicians Surg Pak"},{"key":"2025093003014306700_vzaf040-B8","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4103\/ijdvl.IJDVL_589_18","article-title":"Comparison of efficacy of platelet-rich plasma therapy with or without topical 5% minoxidil in male-type baldness: a randomized, double-blind placebo control trial","volume":"86","author":"Singh","year":"2020","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"2025093003014306700_vzaf040-B9","first-page":"29","article-title":"Platelet-rich plasma microneedling versus 5% topical minoxidil in the treatment of patterned hair loss","volume":"13","author":"Farid","year":"2016","journal-title":"Journal Egypt Wom Derm Soc"},{"key":"2025093003014306700_vzaf040-B10","first-page":"905","article-title":"A randomized control trial comparing the efficacy of platelet-rich plasma and 5% topical minoxidil for the treatment of androgenetic alopecia","volume":"22","author":"Asim","year":"2023","journal-title":"J Drugs Dermatol"},{"key":"2025093003014306700_vzaf040-B11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4103\/ijt.ijt_64_18","article-title":"A study to compare the efficacy of platelet-rich plasma and minoxidil therapy for the treatment of androgenetic alopecia","volume":"11","author":"Verma","year":"2019","journal-title":"Int J Trichology"},{"key":"2025093003014306700_vzaf040-B12","doi-asserted-by":"crossref","first-page":"843127","DOI":"10.3389\/fmed.2022.843127","article-title":"Treatment of androgenetic alopecia using PRP to target dysregulated mechanisms and pathways","volume":"9","author":"Abdin","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"2025093003014306700_vzaf040-B13","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4103\/JCAS.JCAS_50_16","article-title":"A randomized head study of the efficacy of placebo versus platelet-rich plasma injections in the treatment of androgenetic alopecia","volume":"10","author":"Kachhawa","year":"2017","journal-title":"J Cutan Aesthet Surg"},{"key":"2025093003014306700_vzaf040-B14","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.jaad.2020.07.006","article-title":"Evaluation of platelet-rich plasma as a treatment for androgenetic alopecia: a randomized controlled 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androgenetic alopecia: a meta-analysis","volume":"48","author":"Li","year":"2024","journal-title":"Aesthetic Plast Surg"},{"key":"2025093003014306700_vzaf040-B18","first-page":"185","article-title":"Topical minoxidil: systematic review and meta-analysis of its efficacy in androgenetic alopecia","volume":"13","author":"Gupta","year":"2015","journal-title":"Skinmed"},{"key":"2025093003014306700_vzaf040-B19","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1097\/DSS.0000000000002168","article-title":"A randomized, controlled pilot trial comparing platelet-rich plasma to topical minoxidil foam for treatment of androgenetic alopecia in women","volume":"46","author":"Bruce","year":"2020","journal-title":"Dermatol Surg"},{"key":"2025093003014306700_vzaf040-B20","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.3390\/ijms21082702","article-title":"Systematic review of platelet-rich plasma use in androgenetic alopecia compared with minoxidil\u00ae, finasteride\u00ae, and adult 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