{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T04:58:26Z","timestamp":1764219506063,"version":"3.46.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Histoid leprosy (HL) is a very rare and highly infectious variant of lepromatous leprosy, presenting as skin-coloured, succulent nodules and plaques on apparently healthy skin. It is histologically characterized by a dense bundle of histiocytes arranged in storiform manner. Usually, it occurs in patients with leprosy who relapse after dapsone monotherapy or inadequate antileprotic treatment; it can even arise de novo. We present a case of umbilicated presentation in a patient with a case of relapse HL, even after adequate treatment with multibacillary multidrug therapy for 12 months. Although rare, the higher load of lepra bacilli in these cases makes it a matter of concern, and challenging for leprologists to make early diagnosis and treatment.<\/jats:p>","DOI":"10.1093\/skinhd\/vzaf067","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T11:32:56Z","timestamp":1754393576000},"page":"467-469","source":"Crossref","is-referenced-by-count":0,"title":["An unusual presentation in relapse case of histoid leprosy"],"prefix":"10.1093","volume":"5","author":[{"given":"Mahesh","family":"Mathur","sequence":"first","affiliation":[{"name":"Department of Dermatology, College of Medical Sciences , Bharatpur ,","place":["Nepal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumit","family":"Paudel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medical Sciences , Bharatpur ,","place":["Nepal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2859-0376","authenticated-orcid":false,"given":"Nabita","family":"Bhattarai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medical Sciences , Bharatpur ,","place":["Nepal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5844-8910","authenticated-orcid":false,"given":"Sandhya","family":"Regmi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medical Sciences , Bharatpur ,","place":["Nepal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6438-1930","authenticated-orcid":false,"given":"Sambidha","family":"Karki","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medical Sciences , Bharatpur 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institute","volume":"11","author":"Sindhushree","year":"2021","journal-title":"J Pathol Nep"},{"volume-title":"International Textbook of Leprosy","year":"2017","author":"Kumar","key":"2025112622312813400_vzaf067-B3"},{"volume-title":"National Leprosy Strategy 2021-2025","year":"2021","author":"Government of Nepal, Ministry of Health and Population","key":"2025112622312813400_vzaf067-B4"},{"author":"Government of Nepal, Ministry of Health and Population","key":"2025112622312813400_vzaf067-B5"},{"key":"2025112622312813400_vzaf067-B6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/ddg.13777","article-title":"Umbilicated lesions in a de novo case of histoid leprosy","volume":"17","author":"Kumar Kansal","year":"2019","journal-title":"J Dtsch Dermatol Ges"},{"key":"2025112622312813400_vzaf067-B7","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ad.2019.07.011","article-title":"Lepra histioide, un enemigo a\u00fan no erradicado","volume":"112","author":"Calvache","year":"2021","journal-title":"Actas Dermosifiliogr"},{"key":"2025112622312813400_vzaf067-B8","first-page":"21","article-title":"Wade histoid leprosy masquerading as eruptive xanthomas","volume":"14","author":"Monga","year":"2008","journal-title":"Dermatol Online J"},{"key":"2025112622312813400_vzaf067-B9","doi-asserted-by":"crossref","first-page":"474","DOI":"10.18203\/issn.2455-4529.IntJResDermatol20202650","article-title":"Clinico-pathological study of cases of histoid leprosy","volume":"6","author":"Kaveri","year":"2020","journal-title":"Int J Res Dermatol"},{"key":"2025112622312813400_vzaf067-B10","first-page":"Article 10","article-title":"Immunomodulators in leprosy: a narrative review","volume":"8","author":"Kimberly","year":"2024","journal-title":"J Gen Pro DVI"},{"key":"2025112622312813400_vzaf067-B11","first-page":"40","article-title":"Leprosy vaccines \u2013 a voyage 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