{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T12:25:08Z","timestamp":1774959908502,"version":"3.50.1"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pyoderma gangrenosum (PG) is a rare skin condition characterized by chronic, painful ulcerations. It is considered a diagnosis of exclusion, often resulting in diagnostic delay. Histological results in PG, even when biopsied despite a risk of pathergy, are nonspecific.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To examine retrospectively the utility of biopsies in the diagnosis of 58 patients treated for PG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records were reviewed to compare biopsy results versus the efficacy of diagnostic rating systems (Delphi, Su, PARACELSUS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 58 patients, 26 (45%) underwent biopsies, with only 10 (38%) contributing to a PG diagnosis. As a single-centre and retrospective study, documentation style and sample size limit generalizability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Given risk of pathergy, nonspecific histopathological findings and low sensitivity, in our opinion, based on this small sample size, biopsies have limited diagnostic value for PG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/skinhd\/vzaf087","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T12:19:03Z","timestamp":1760530743000},"page":"90-93","source":"Crossref","is-referenced-by-count":1,"title":["The utility of biopsy in pyoderma gangrenosum: a retrospective cohort study"],"prefix":"10.1093","volume":"6","author":[{"given":"Angel\u00a0M","family":"Moore","sequence":"first","affiliation":[{"name":"Dartmouth College, Geisel School of Medicine , Hanover, NH ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie L","family":"Karch","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Dartmouth College, Dartmouth Hitchcock Medical Center , Lebanon, NH ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine\u00a0E","family":"Bradley","sequence":"additional","affiliation":[{"name":"Dartmouth College, Geisel School of Medicine , Hanover, NH ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjana","family":"Stevanovic","sequence":"additional","affiliation":[{"name":"Dartmouth College, Geisel School of Medicine , Hanover, NH ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iman","family":"Salem","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Dartmouth College, Dartmouth Hitchcock Medical Center , Lebanon, NH ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dylan\u00a0J","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Dartmouth College, Dartmouth Hitchcock Medical Center , Lebanon, NH ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian\u00a0J","family":"Simmons","sequence":"additional","affiliation":[{"name":"Dartmouth College, Geisel School of Medicine , Hanover, NH ,","place":["USA"]},{"name":"Department of Dermatology, Dartmouth College, Dartmouth Hitchcock Medical Center , Lebanon, NH ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"2026033107424859300_vzaf087-B1","first-page":"569","article-title":"Research advances on the pathogenesis and diagnosis of pyoderma gangrenosum","volume":"38","author":"Yang","year":"2022","journal-title":"Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi"},{"key":"2026033107424859300_vzaf087-B2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jid.2020.04.019","article-title":"Comparison of three diagnostic frameworks for pyoderma gangrenosum","volume":"141","author":"Haag","year":"2021","journal-title":"J Invest Dermatol"},{"key":"2026033107424859300_vzaf087-B3","doi-asserted-by":"crossref","first-page":"224","DOI":"10.7861\/clinmedicine.19-3-224","article-title":"Pyoderma gangrenosum\u00a0\u2013 a guide to diagnosis and management","volume":"19","author":"George","year":"2019","journal-title":"Clin Med"},{"key":"2026033107424859300_vzaf087-B4","doi-asserted-by":"crossref","first-page":"h2958","DOI":"10.1136\/bmj.h2958","article-title":"Comparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial","volume":"350","author":"Ormerod","year":"2015","journal-title":"BMJ"},{"key":"2026033107424859300_vzaf087-B5","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1001\/jamadermatol.2017.5980","article-title":"Diagnostic criteria of ulcerative pyoderma gangrenosum: a Delphi consensus of international experts","volume":"154","author":"Maverakis","year":"2018","journal-title":"JAMA Dermatol"},{"key":"2026033107424859300_vzaf087-B6","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1056\/NEJMoa013383","article-title":"Skin ulcers misdiagnosed as pyoderma gangrenosum","volume":"347","author":"Weenig","year":"2002","journal-title":"N Engl J Med"}],"container-title":["Skin Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/6\/2\/90\/66326305\/vzaf087.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/6\/2\/90\/66326305\/vzaf087.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:42:52Z","timestamp":1774957372000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/skinhd\/article\/6\/2\/90\/8418301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,9]]},"references-count":6,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,1,9]]},"published-print":{"date-parts":[[2026,3,31]]}},"URL":"https:\/\/doi.org\/10.1093\/skinhd\/vzaf087","relation":{},"ISSN":["2690-442X"],"issn-type":[{"value":"2690-442X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2026,1,9]]}}}