{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:05:23Z","timestamp":1790809523732,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In an increasingly urbanized world, environmental pollution is recognized for its adverse effects on both systemic and skin health. While its role in conditions such as atopic dermatitis and psoriasis is well documented, its impact on acne vulgaris remains less clear. This review aims to evaluate existing literature examining the association between environmental pollutants \u2013 such as particulate matter (PM2.5, PM10), nitrogen oxides (NO2, NOx) and traffic-related emissions \u2013 and the development, severity or exacerbation of acne. A systematic search of peer-reviewed English-language studies published between 2010 and 2025 was conducted using PubMed. Search terms included \u2018air pollution\u2019, \u2018particulate matter\u2019, \u2018PM2.5\u2019, \u2018PM10\u2019, \u2018NO2\u2019, \u2018NOx\u2019, \u2018environmental pollution\u2019, \u2018traffic pollution\u2019, \u2018acne\u2019 and \u2018acne vulgaris\u2019. Studies were included if they investigated the relationship between environmental pollutants and acne in human populations. Of the 27 studies identified, 17 met inclusion criteria. Systematic reviews were also incorporated to provide broader context. Several studies demonstrated significant associations between pollutant exposure and acne exacerbation. A time-series study in China involving 71 625 outpatient visits found that each 10 \u03bcg m\u20133 increase in SO2 and NO2 correlated with 1.02% and 2.13% increases in acne-related visits, respectively. Other studies appear to show pollutants being associated with increased sebum production and reduction of antioxidants. Proposed mechanisms include oxidative stress, microbiome disruption and follicular hyperkeratinization. However, study heterogeneity, lack of diversity and limited control for confounders limit generalizability. Longitudinal research is needed to clarify pollution\u2019s role in acne and inform targeted prevention strategies.<\/jats:p>","DOI":"10.1093\/skinhd\/vzaf090","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T11:43:18Z","timestamp":1760787798000},"page":"12-19","source":"Crossref","is-referenced-by-count":3,"title":["Impact of environmental pollution on acne: a systematic review"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7673-6471","authenticated-orcid":false,"given":"Isobel R","family":"Okeah","sequence":"first","affiliation":[{"name":"School of Medicine and Dentistry, University of Lancashire , Preston ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8310-5750","authenticated-orcid":false,"given":"Usamah M","family":"Afzal","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Harrogate District Hospital , Harrogate ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8588-791X","authenticated-orcid":false,"given":"Faisal R","family":"Ali","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry, University of Lancashire , Preston ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"2026020400220302000_vzaf090-B1","doi-asserted-by":"crossref","first-page":"9888","DOI":"10.3390\/ijms25189888","article-title":"Particulate matter and its molecular effects on skin: implications for various skin diseases","volume":"25","author":"Paik","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026020400220302000_vzaf090-B2","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic 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