{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:38:02Z","timestamp":1792463882978,"version":"4.5.0"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Klippel\u2013Tr\u00e9naunay syndrome (KTS) is a rare congenital vascular disorder that typically presents with capillary and venous malformations, limb hypertrophy and, in some cases, lymphatic abnormalities. We report a 3-year-old boy with extensive vascular malformations affecting the left lower limb, predominantly involving the penoscrotal region \u2013 an uncommon presentation without systemic involvement. This case illustrates the diagnostic complexity of genitourinary KTS and emphasizes the need for vigilant monitoring, multidisciplinary input and tailored management to reduce complications and improve long-term outcomes.<\/jats:p>","DOI":"10.1093\/skinhd\/vzaf103","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T13:22:38Z","timestamp":1762435358000},"page":"164-167","source":"Crossref","is-referenced-by-count":1,"title":["Capillary malformations in unusual territory: Klippel\u2013Tr\u00e9naunay syndrome with penoscrotal involvement"],"prefix":"10.1093","volume":"6","author":[{"given":"Mahesh","family":"Mathur","sequence":"first","affiliation":[{"name":"Department of Dermatology, College of Medical Sciences , Bharatpur ,","place":["Nepal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Paudel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medical Sciences , Bharatpur ,","place":["Nepal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2859-0376","authenticated-orcid":false,"given":"Nabita","family":"Bhattarai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medical Sciences , Bharatpur ,","place":["Nepal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5844-8910","authenticated-orcid":false,"given":"Sandhya","family":"Regmi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medical Sciences , Bharatpur ,","place":["Nepal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himanshu","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medical Sciences , Bharatpur ,","place":["Nepal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6438-1930","authenticated-orcid":false,"given":"Sambidha","family":"Karki","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medical Sciences , Bharatpur ,","place":["Nepal"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"2026033107433455600_vzaf103-B1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1186\/s13256-021-03029-4","article-title":"A neonate with Klippel\u2013Tr\u00e9naunay syndrome: a case report","volume":"15","author":"Sikakulya","year":"2021","journal-title":"J Med Case Rep"},{"key":"2026033107433455600_vzaf103-B2","doi-asserted-by":"crossref","first-page":"e239420","DOI":"10.1136\/bcr-2020-239420","article-title":"Klippel\u2013Trenaunay syndrome in a young patient with the involvement of gastrointestinal and genitourinary tracts: an unusual and rare presentation","volume":"14","author":"Shaikh","year":"2021","journal-title":"BMJ Case Rep"},{"key":"2026033107433455600_vzaf103-B3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/ajmg.a.36836","article-title":"PIK3CA-Related Overgrowth Spectrum (PROS): diagnostic and testing eligibility criteria, differential diagnosis, and evaluation","volume":"167","author":"Keppler-Noreuil","year":"2015","journal-title":"Am J Med Genet A"},{"key":"2026033107433455600_vzaf103-B4","first-page":"648","article-title":"Urogenital involvement in Klippel\u2013Trenaunay\u2013Weber syndrome: treatment options and results","volume":"69","author":"Vicentini","year":"2007","journal-title":"Urology"},{"key":"2026033107433455600_vzaf103-B5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.clinimag.2020.06.011","article-title":"Genitourinary involvement in pediatric patients with Klippel\u2013Trenaunay syndrome","volume":"67","author":"Patel","year":"2020","journal-title":"Clin Imaging"},{"key":"2026033107433455600_vzaf103-B6","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.juro.2006.11.099","article-title":"Klippel\u2013Trenaunay syndrome: incidence and treatment of genitourinary sequelae","volume":"177","author":"Husmann","year":"2007","journal-title":"J Urol"},{"key":"2026033107433455600_vzaf103-B7","doi-asserted-by":"crossref","first-page":"e20153257","DOI":"10.1542\/peds.2015-3257","article-title":"Efficacy and safety of sirolimus in the treatment of complicated vascular anomalies","volume":"137","author":"Adams","year":"2016","journal-title":"Pediatrics"}],"container-title":["Skin Health and 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