{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:02:13Z","timestamp":1780048933024,"version":"3.53.1"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>ATP2C1-nonsyndromic epidermal differentiation disorder, also known as familial benign chronic pemphigus or Hailey\u2013Hailey disease, is a rare autosomal dominant acantholytic disorder characterized by relapsing and remitting painful vesicles and erosions in flexural areas. At present, there is no effective cure. Current treatments focus on symptomatic management and improving quality of life. We report a case in which a patient experienced notable clinical improvement with the use of topical ruxolitinib 1.5% cream.<\/jats:p>","DOI":"10.1093\/skinhd\/vzag002","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T12:36:47Z","timestamp":1769258207000},"page":"310-312","source":"Crossref","is-referenced-by-count":0,"title":["Improvement of recalcitrant Hailey\u2013Hailey disease (\n                    <i>ATP2C1<\/i>\n                    -nonsyndromic epidermal differentiation disorder) with topical ruxolitinib 1.5%\u00a0cream"],"prefix":"10.1093","volume":"6","author":[{"given":"Alyssa","family":"Jobe","sequence":"first","affiliation":[{"name":"Department of Dermatology, Medical College of Wisconsin , Wauwatosa, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical College of Wisconsin , Wauwatosa, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanelle","family":"Briggs","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical College of Wisconsin , Wauwatosa, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip C","family":"Berce","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical College of Wisconsin , Wauwatosa, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maia K","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical College of Wisconsin , Wauwatosa, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolyn A","family":"Wanat","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical College of Wisconsin , Wauwatosa, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"2026052905170935600_vzag002-B1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/71701","article-title":"Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease","volume":"24","author":"Hu","year":"2000","journal-title":"Nat Genet"},{"key":"2026052905170935600_vzag002-B2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jdcr.2023.10.004","article-title":"Recalcitrant Hailey-Hailey disease successfully treated with topical ruxolitinib cream and dupilumab","volume":"42","author":"Khang","year":"2023","journal-title":"JAAD Case Rep"},{"key":"2026052905170935600_vzag002-B3","doi-asserted-by":"crossref","first-page":"e786","DOI":"10.1111\/jdv.20620","article-title":"Refractory anogenital Hailey-Hailey disease successfully treated with topical ruxolitinib","volume":"39","author":"Ly","year":"2025","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2026052905170935600_vzag002-B4","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/j.1365-2133.2005.06394.x","article-title":"Effects of drugs and anticytokine antibodies on expression of ATP2A2 and ATP2C1 in cultured normal human keratinocytes","volume":"152","author":"Mayuzumi","year":"2005","journal-title":"Br J Dermatol"},{"key":"2026052905170935600_vzag002-B5","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/bjd.20475","article-title":"Hailey\u2013Hailey disease treated with dupilumab: a case series","volume":"185","author":"Alzahrani","year":"2021","journal-title":"Br J Dermatol"},{"key":"2026052905170935600_vzag002-B6","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/ced\/llad023","article-title":"Improvement of Hailey-Hailey disease with abrocitinib","volume":"48","author":"Li","year":"2023","journal-title":"Clin Exp Dermatol"}],"container-title":["Skin Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/6\/3\/310\/67339912\/vzag002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/6\/3\/310\/67339912\/vzag002.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:17:15Z","timestamp":1780046235000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/skinhd\/article\/6\/3\/310\/8519347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3,13]]},"published-print":{"date-parts":[[2026,5,29]]}},"URL":"https:\/\/doi.org\/10.1093\/skinhd\/vzag002","relation":{},"ISSN":["2690-442X"],"issn-type":[{"value":"2690-442X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,3,13]]}}}