{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:02:12Z","timestamp":1780048932130,"version":"3.53.1"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lichen planus is an autoimmune inflammatory condition of unknown aetiology that affects the skin, nails and mucous membranes. There is currently a paucity of lichen planus treatment data in the Asian population. We present a case of an older Asian woman with metabolic syndrome and eruptive lichen planus that was successfully treated with dupilumab monotherapy. There is a plethora of clinical subtypes of lichen planus of which pruritus is a prominent symptom and can cause significant distress and reduction in quality of life. Metabolic syndrome is a prevalent health concern worldwide. It is a well-\u00addescribed entity of metabolic abnormalities, which include hypertension, central obesity, insulin resistance and dyslipidaemia. Metabolic syndrome is believed to play a significant role in the pathophysiology of chronic inflammatory dermatoses such as psoriasis and lichen planus due to the involvement of T helper 1 cytokines interleukin (IL)-2, IL-4, IL-6 and IL-10, and tumour necrosis factor-\u03b1 in metabolic syndrome, which also contributes to the pathogenesis of lichen planus. The burden that this condition places on patients also poses challenges in terms of management options in individuals with metabolic syndrome. We describe the case of an older Asian woman with metabolic syndrome who developed sudden-onset extensive eruptive lichen planus and was successfully treated with dupilumab monotherapy.<\/jats:p>","DOI":"10.1093\/skinhd\/vzag027","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:56:35Z","timestamp":1771505795000},"page":"326-328","source":"Crossref","is-referenced-by-count":0,"title":["Dupilumab as a novel therapy for eruptive lichen planus in an Asian patient with metabolic syndrome"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8476-9489","authenticated-orcid":false,"given":"Rui Chong","family":"Tay","sequence":"first","affiliation":[{"name":"Faculty of Life Sciences & Medicine, King\u2019s College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Tan","sequence":"additional","affiliation":[{"name":"Mount Elizabeth Hospital , Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suat Hoon","family":"Tan","sequence":"additional","affiliation":[{"name":"National Skin Centre \u2013 Dermatology , Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"2026052905170536200_vzag027-B1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.4103\/ijd.IJD_553_17","article-title":"Eruptive lichen planus, a marker of metabolic syndrome","volume":"64","author":"Geetharani","year":"2019","journal-title":"Indian J Dermatol"},{"key":"2026052905170536200_vzag027-B2","doi-asserted-by":"crossref","first-page":"e315","DOI":"10.1002\/ski2.315","article-title":"Metabolic syndrome in patients with lichen planus; a case-control study","volume":"4","author":"Mathur","year":"2024","journal-title":"Skin Health Dis"},{"key":"2026052905170536200_vzag027-B3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4103\/jrms.JRMS_585_20","article-title":"Skin and metabolic syndrome. A review of the possible associations","volume":"26","author":"Adibi","year":"2021","journal-title":"J Res Med Sci"},{"key":"2026052905170536200_vzag027-B4","doi-asserted-by":"crossref","first-page":"367","DOI":"10.18231\/j.ijced.2024.066","article-title":"Skin as a mirror of metabolic syndrome; do some dermatoses alarm internal metabolic sinister?","volume":"10","author":"Vora","year":"2024","journal-title":"IP Indian J Clin Exp Dermatol"},{"key":"2026052905170536200_vzag027-B5","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1111\/jdv.16464","article-title":"European S1 guidelines on the management of lichen planus: a cooperation of the European Dermatology Forum with the European Academy of Dermatology and Venereology","volume":"34","author":"Ioannides","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2026052905170536200_vzag027-B6","first-page":"108","article-title":"Rapid resolution of widespread cutaneous lichen planus and generalized pruritus in an elderly patient following treatment with dupilumab","volume":"30","author":"Kazemi","year":"2022","journal-title":"J Am Acad Dermatol"},{"key":"2026052905170536200_vzag027-B7","doi-asserted-by":"crossref","first-page":"eaav7561","DOI":"10.1126\/scitranslmed.aav7561","article-title":"IFN-gamma enhances cell-mediated cytotoxicity against keratinocytes via JAK2\/STAT1 in lichen planus","volume":"11","author":"Shao","year":"2019","journal-title":"Sci Transl Med"},{"key":"2026052905170536200_vzag027-B8","first-page":"E8","article-title":"Dupilumab for the treatment of lichen planus","volume":"107","author":"Pousti","year":"2021","journal-title":"Cutis"},{"key":"2026052905170536200_vzag027-B9","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1093\/ced\/llae425","article-title":"Refractory lichen planus: success with dupilumab","volume":"50","author":"Read","year":"2025","journal-title":"Clin Exp Dermatol"}],"container-title":["Skin Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/6\/3\/326\/68116718\/vzag027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/6\/3\/326\/68116718\/vzag027.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:17:12Z","timestamp":1780046232000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/skinhd\/article\/6\/3\/326\/8659368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,4,20]]},"published-print":{"date-parts":[[2026,5,29]]}},"URL":"https:\/\/doi.org\/10.1093\/skinhd\/vzag027","relation":{},"ISSN":["2690-442X"],"issn-type":[{"value":"2690-442X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,4,20]]}}}