{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:08:31Z","timestamp":1790726911857,"version":"4.1.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Histoid Hansen disease is a distinct variant of lepromatous leprosy characterized by nodular lesions, spindle-shaped histiocytes and a very high bacillary load, often associated with relapse and drug resistance. While standard multibacillary multidrug therapy (MB-MDT) remains the mainstay of treatment, very short-course bactericidal regimens appear inadequate in bacillary-rich disease. We report a case of histoid leprosy treated with adjunctive rifampicin and ofloxacin for 3 months alongside MB-MDT, resulting in marked clinical regression. Although causality cannot be inferred from a single case, this observation suggests a potential role for short-term intensified bactericidal therapy as an adjunct in selected high-risk morphological variants.<\/jats:p>","DOI":"10.1093\/skinhd\/vzag092","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:48:01Z","timestamp":1778932081000},"page":"803-807","source":"Crossref","is-referenced-by-count":0,"title":["Adjunctive rifampicin\u2013ofloxacin therapy in histoid Hansen disease with high bacillary burden: a case report"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7499-0744","authenticated-orcid":false,"given":"Vangala Naga","family":"Nitya","sequence":"first","affiliation":[{"name":"Datta Meghe Institute of Higher Education and Research, Department of Dermatology , Venereology and Leprosy, Wardha 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,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1218-0181","authenticated-orcid":false,"given":"Varun","family":"H","sequence":"additional","affiliation":[{"name":"Datta Meghe Institute of Higher Education and Research, Department of Dermatology , Venereology and Leprosy, Wardha ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"2026092919521599300_vzag092-B1","first-page":"129","article-title":"The histoid variety of lepromatous leprosy","volume":"31","author":"Wade","year":"1963","journal-title":"Int J Lepr"},{"key":"2026092919521599300_vzag092-B2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/qjmed\/hcz043","article-title":"Does histoid leprosy represent a locally hyperimmune variant of lepromatous 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