{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:53:36Z","timestamp":1791201216295,"version":"4.2.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1093\/sleep\/33.7.869","type":"journal-article","created":{"date-parts":[[2017,2,5]],"date-time":"2017-02-05T15:59:18Z","timestamp":1486310358000},"page":"869-874","source":"Crossref","is-referenced-by-count":117,"title":["Anti-Tribbles Homolog 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy"],"prefix":"10.1093","volume":"33","author":[{"given":"Minae","family":"Kawashima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poul","family":"Jennum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stine","family":"Knudsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sona","family":"Nevsimalova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Plazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Mignot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170420031440_b1","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1086\/318799","article-title":"Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups","volume":"68","year":"2001","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t20170420031440_b2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0140-6736(99)05582-8","article-title":"Hypocretin (orexin) defciency in human narcolepsy","volume":"355","year":"2000","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170420031440_b3","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1001\/archneur.59.10.1553","article-title":"The role of cerebrospinal fuid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias","volume":"59","year":"2002","journal-title":"Arch Neurol"},{"key":"key\n\t\t\t\t20170420031440_b4","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/79690","article-title":"A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains","volume":"6","year":"2000","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170420031440_b5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0092-8674(00)81965-0","article-title":"The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene","volume":"98","year":"1999","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170420031440_b6","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)81973-X","article-title":"Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation","volume":"98","year":"1999","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170420031440_b7","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/sleep\/29.5.601","article-title":"The frustrating and mostly fruitless search for an autoimmune cause of narcolepsy","volume":"29","year":"2006","journal-title":"Sleep"},{"key":"key\n\t\t\t\t20170420031440_b8","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/ng.372","article-title":"Narcolepsy is strongly associated with the T-cell receptor alpha locus","volume":"41","year":"2009","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170420031440_b9","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1172\/JCI41366","article-title":"Elevated Tribbles homolog 2-specifc antibody levels in narcolepsy patients","volume":"120","year":"2010","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170420031440_b10","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.molimm.2004.11.020","article-title":"Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display","volume":"42","year":"2005","journal-title":"Mol Immunol"},{"key":"key\n\t\t\t\t20170420031440_b11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0009-8981(01)00747-1","article-title":"Anti-CYP2D6 antibodies detected by quantitative radioligand assay and relation to antibodies to liver-specific arginase in patients with autoimmune hepatitis","volume":"316","year":"2002","journal-title":"Clinica Chimica Acta"},{"key":"key\n\t\t\t\t20170420031440_b12","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0022-1759(98)00213-0","article-title":"A novel assay for detecting antibodies to cytochrome P4502D6, the molecular target of liver kidney microsomal antibody type 1","volume":"223","year":"1999","journal-title":"J Immunol Methods"},{"key":"key\n\t\t\t\t20170420031440_b13","article-title":"International Classification of Sleep Disorders","author":"American Academy of Sleep Medicine","year":"2005","edition":"2nd"},{"key":"key\n\t\t\t\t20170420031440_b14","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1093\/sleep\/29.11.1429","article-title":"A study of the diagnostic utility of HLA typing, CSF hypocretin-1 measurements, and MSLT testing for the diagnosis of narcolepsy in 163 Korean patients with unexplained excessive daytime sleepiness","volume":"29","year":"2006","journal-title":"Sleep"},{"key":"key\n\t\t\t\t20170420031440_b15","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S1474-4422(08)70140-6","article-title":"CSF hypocretin-1 assessment in sleep and neurological disorders","volume":"7","year":"2008","journal-title":"Lancet Neurol"},{"key":"key\n\t\t\t\t20170420031440_b16","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/sleep\/29.5.633","article-title":"Detection of autoantibodies against hypocretin, hcrtrl, and hcrtr2 in narcolepsy: anti-Hcrt system antibody in narcolepsy","volume":"29","year":"2006","journal-title":"Sleep"},{"key":"key\n\t\t\t\t20170420031440_b17","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1084\/jem.55.2.267","article-title":"Antigenic streptococcal hemolysin","volume":"55","year":"1932","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170420031440_b18","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/sleep\/32.8.979","article-title":"Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset","volume":"32","year":"2009","journal-title":"Sleep"},{"key":"key\n\t\t\t\t20170420031440_b19","volume-title":"Evaluating Medical Tests","year":"1992"},{"key":"key\n\t\t\t\t20170420031440_b20","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/sleep\/33.7.875","article-title":"Anti-Tribbles homolog 2 autoantibodies in Japanese patients with narcolepsy","volume":"33","year":"2010","journal-title":"Sleep"},{"key":"key\n\t\t\t\t20170420031440_b21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1749-6632.2009.05127.x","article-title":"Epitope specificity and significance in systemic autoimmune diseases","volume":"1183","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t20170420031440_b22","doi-asserted-by":"crossref","first-page":"S238","DOI":"10.1016\/j.jaci.2009.09.041","article-title":"Diagnostic testing and interpretation of tests for autoimmunity","volume":"125","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"key\n\t\t\t\t20170420031440_b23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1210\/jc.2009-1365","article-title":"Clinical applications of diabetes antibody testing","volume":"95","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170420031440_b24","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1365-2869.2009.00756.x","article-title":"Medical exposures in youth and the frequency of narcolepsy with cataplexy: a population-based case-control study in genetically predisposed people","volume":"19","year":"2010","journal-title":"J Sleep Res"},{"key":"key\n\t\t\t\t20170420031440_b25","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1189\/jlb.0709517","article-title":"Infections and autoimmunity: the multifaceted relationship","volume":"87","year":"2010","journal-title":"J Leukoc Biol"},{"key":"key\n\t\t\t\t20170420031440_b26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4103\/0301-4738.58468","article-title":"Current approach in diagnosis and management of anterior uveitis","volume":"58","year":"2010","journal-title":"Indian J Ophthalmol"},{"key":"key\n\t\t\t\t20170420031440_b27","doi-asserted-by":"crossref","first-page":"e9555","DOI":"10.1371\/journal.pone.0009555","article-title":"IgG abnormality in narcolepsy and idiopathic hypersomnia","volume":"5","year":"2010","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170420031440_b28","doi-asserted-by":"crossref","first-page":"e4254","DOI":"10.1371\/journal.pone.0004254","article-title":"IGFBP3 colocalizes with and regulates hypocretin (orexin)","volume":"4","year":"2009","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170420031440_b29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.smrv.2007.07.010","article-title":"Narcolepsy: immunological aspects","volume":"12","year":"2008","journal-title":"Sleep Med Rev"},{"key":"key\n\t\t\t\t20170420031440_b30","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/labinvest.2009.108","article-title":"Potentiation of a functional autoantibody in narcolepsy by a cholinesterase inhibitor","volume":"89","year":"2009","journal-title":"Lab Invest"}],"container-title":["Sleep"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/sleep\/article-pdf\/33\/7\/869\/13665127\/sleep-33-7-869.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T08:40:04Z","timestamp":1568796004000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/sleep\/article-lookup\/doi\/10.1093\/sleep\/33.7.869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"URL":"https:\/\/doi.org\/10.1093\/sleep\/33.7.869","relation":{},"ISSN":["1550-9109","0161-8105"],"issn-type":[{"value":"1550-9109","type":"electronic"},{"value":"0161-8105","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}