{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:38:08Z","timestamp":1763707088417,"version":"3.43.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"am","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study provided a preliminary examination of indices of obstructive sleep apnea (OSA) and sleep disruptions in adults with Down syndrome (DS), and their associations with Alzheimer\u2019s disease (AD) pathology and symptomatology. Ninety-three adults with DS (aged 25\u201361 years) from the Alzheimer Biomarker Consortium \u2013 Down Syndrome completed cognitive assessments, MRI and PET scans (assessing amyloid-beta [A\u03b2] and tau), and a one-night home sleep study using the WatchPAT-300 device. Study partners also reported on depressive symptoms and diagnoses. Correlational analyses examined relationships between sleep variables, PET biomarkers, and AD symptomatology (cognitive functioning and depressive mood), controlling for sociodemographics. Eighty-one participants (87%) completed valid WatchPAT data. Of these, 60 (74%) screened positive for OSA, and an additional 11 had a prior OSA diagnosis and used CPAP during the test night. Nearly half (45%) of those screening positive for OSA had no prior diagnosis, indicating under-detection. Among the 22 participants using OSA treatment, 50% continued to show sleep-disordered breathing, suggesting suboptimal treatment effectiveness. Higher wake percentage and shorter total sleep time were associated with greater A\u03b2 and tau burden. Cognitive performance was negatively associated with wake percentage, total sleep time, and oxygenation indices (minimum oxygen, desaturation, and time \u2264 88% oxygen). Depressive symptoms were negatively related to total sleep time. These findings add preliminary evidence linking sleep disruption and OSA with AD-related pathology and symptomatology. Larger, longitudinal studies are needed to confirm these associations and evaluate whether improving sleep quality and treating OSA may help delay AD onset in this high-risk population.<\/jats:p>","DOI":"10.1093\/sleep\/zpaf044","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T17:48:32Z","timestamp":1755020912000},"source":"Crossref","is-referenced-by-count":1,"title":["Preliminary Investigation of Obstructive Sleep Apnea and Alzheimer\u2019s Disease in Down Syndrome"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3440-0532","authenticated-orcid":false,"given":"Dasoo Milton","family":"Yoon","sequence":"first","affiliation":[{"name":"Waisman Center, University of Wisconsin, Madison , Madison, Wisconsin 53705 ,","place":["USA"]},{"name":"Department of Human Development and Family Studies, University of Wisconsin , Madison 53705 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2619-5654","authenticated-orcid":false,"given":"David","family":"Plante","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Wisconsin, Madison , Madison, Wisconsin 53705 \u00a0","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Fleming","sequence":"additional","affiliation":[{"name":"Waisman Center, University of Wisconsin, Madison , Madison, Wisconsin 53705 ,","place":["USA"]},{"name":"Department of Human Development and Family Studies, University of Wisconsin , Madison 53705 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Handen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh , Pittsburgh, Pennsylvania 15213 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2243-3547","authenticated-orcid":false,"given":"Patrick","family":"Lao","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Sergievsky Center, and Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University , New York, New York 10032 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie","family":"Peven","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh , Pittsburgh, Pennsylvania 15213 ,","place":["USA"]},{"name":"VA Pittsburgh Healthcare System , Pittsburgh, PA 15240"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley","family":"Christian","sequence":"additional","affiliation":[{"name":"Waisman Center, University of Wisconsin, Madison , Madison, Wisconsin 53705 ,","place":["USA"]},{"name":"Department of Psychiatry, University of Wisconsin, Madison , Madison, Wisconsin 53705 \u00a0","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozioma","family":"Okonkwo","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Wisconsin-Madison , Madison, Wisconsin 53705 \u00a0","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Laymon","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Pittsburgh , Pittsburgh, Pennsylvania 15213 ,","place":["USA"]},{"name":"Department of Bioengineering, University of Pittsburgh , Pittsburgh, Pennsylvania 15260 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beau","family":"Ances","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine in St. Louis , St. Louis, Missouri 63130 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christy","family":"Hom","sequence":"additional","affiliation":[{"name":"Department of Psychiatry & Human Behavior, University of California , Irvine, Orange, California 92868 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Helsel","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Kansas Medical Center , Kansas City, Kansas 66160 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigan L","family":"Hartley","sequence":"additional","affiliation":[{"name":"Waisman Center, University of Wisconsin, Madison , Madison, Wisconsin 53705 ,","place":["USA"]},{"name":"Department of Human Development and Family Studies, University of Wisconsin , Madison 53705 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Alzheimer Biomarker Consortium - Down syndrome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beau","family":"M. 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