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While type-1 narcolepsy has been intensively studied, the other subtypes of hypersomnolence, narcolepsy, and hypersomnia are less thoroughly understood. This review summarizes the latest breakthroughs in the field in narcolepsy. The goal of this article is to help the reader to understand better the risk from genetic factors and their interplay with immune, genetic, and epidemiological aspects in narcolepsy.<\/jats:p>","DOI":"10.1093\/sleep\/zsaa099","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T19:42:06Z","timestamp":1590176526000},"source":"Crossref","is-referenced-by-count":15,"title":["Narcolepsy type 1: what have we learned from genetics?"],"prefix":"10.1093","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5302-6429","authenticated-orcid":false,"given":"Hanna M","family":"Ollila","sequence":"first","affiliation":[{"name":"Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland"},{"name":"Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA"},{"name":"Program in Medical and Population Genetics, Broad Institute, Cambridge, MA"},{"name":"Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,22]]},"reference":[{"issue":"9","key":"2020120619342444900_CIT0001","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/79690","article-title":"A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains","volume":"6","author":"Peyron","year":"2000","journal-title":"Nat Med."},{"issue":"6","key":"2020120619342444900_CIT0002","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11940-017-0459-0","article-title":"Cataplexy and Its mimics: clinical recognition and management","volume":"19","author":"Pillen","year":"2017","journal-title":"Curr Treat Options Neurol."},{"issue":"1","key":"2020120619342444900_CIT0003","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s11910-014-0522-0","article-title":"Cataplexy and sleep disorders in Niemann-Pick type C disease","volume":"15","author":"Nevsimalova","year":"2015","journal-title":"Curr Neurol Neurosci Rep."},{"issue":"9","key":"2020120619342444900_CIT0004","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s41582-019-0226-9","article-title":"Narcolepsy \u2013 clinical spectrum, aetiopathophysiology, diagnosis and treatment","volume":"15","author":"Bassetti","year":"2019","journal-title":"Nat Rev Neurol."},{"key":"2020120619342444900_CIT0005","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.smrv.2015.08.007","article-title":"Idiopathic hypersomnia","volume":"29","author":"Billiard","year":"2016","journal-title":"Sleep Med Rev."},{"issue":"3","key":"2020120619342444900_CIT0006","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jsmc.2017.03.009","article-title":"Idiopathic Hypersomnia","volume":"12","author":"Trotti","year":"2017","journal-title":"Sleep Med Clin."},{"key":"2020120619342444900_CIT0007","doi-asserted-by":"crossref","first-page":"101306","DOI":"10.1016\/j.smrv.2020.101306","article-title":"Diagnosis of central disorders of hypersomnolence: a reappraisal by European experts","volume":"52","author":"Lammers","year":"2020","journal-title":"Sleep Med Rev."},{"issue":"8422","key":"2020120619342444900_CIT0008","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0140-6736(85)92072-0","article-title":"Extraordinary association between HLA-DR2 and narcolepsy","volume":"1","author":"Billiard","year":"1985","journal-title":"Lancet"},{"issue":"5","key":"2020120619342444900_CIT0009","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1399-0039.1984.tb02144.x","article-title":"HLA antigens in Japanese patients with narcolepsy. 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