{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:42:41Z","timestamp":1783057361711,"version":"3.54.6"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002661","name":"Fonds de la Recherche Scientifique - FNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wallonia-Brussels Federation"},{"name":"Walloon Excellence in Life Sciences and Biotechnology","award":["WELBIO-CR-2010-06E"],"award-info":[{"award-number":["WELBIO-CR-2010-06E"]}]},{"DOI":"10.13039\/501100005627","name":"University of Li\u00e8ge","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005627","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondation Simone et Pierre Clerdent"},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fondation Recherche Alzheimer","award":["SAO-FRA 2019\/0025"],"award-info":[{"award-number":["SAO-FRA 2019\/0025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study Objectives<\/jats:title>\n                    <jats:p>Sleep disturbances and genetic variants have been identified as risk factors for Alzheimer\u2019s disease (AD). Our goal was to assess whether genome-wide polygenic risk scores (PRS) for AD associate with sleep phenotypes in young adults, decades before typical AD symptom onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We computed whole-genome PRS for AD and extensively phenotyped sleep under different sleep conditions, including baseline sleep, recovery sleep following sleep deprivation, and extended sleep opportunity, in a carefully selected homogenous sample of 363 healthy young men (22.1 years \u00b1 2.7) devoid of sleep and cognitive disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AD PRS was associated with more slow-wave energy, that is, the cumulated power in the 0.5\u20134 Hz EEG band, a marker of sleep need, during habitual sleep and following sleep loss, and potentially with larger slow-wave sleep rebound following sleep deprivation. Furthermore, higher AD PRS was correlated with higher habitual daytime sleepiness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results imply that sleep features may be associated with AD liability in young adults, when current AD biomarkers are typically negative, and support the notion that quantifying sleep alterations may be useful in assessing the risk for developing AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleep\/zsaa137","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T03:22:44Z","timestamp":1594869764000},"source":"Crossref","is-referenced-by-count":16,"title":["Alzheimer\u2019s disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness"],"prefix":"10.1093","volume":"44","author":[{"given":"Vincenzo","family":"Muto","sequence":"first","affiliation":[{"name":"GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Li\u00e8ge, Li\u00e8ge, Belgium"},{"name":"Walloon Excellence in Life sciences and Biotechnology (WELBIO), Wallonia, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Koshmanova","sequence":"additional","affiliation":[{"name":"GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pouya","family":"Ghaemmaghami","sequence":"additional","affiliation":[{"name":"GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Jaspar","sequence":"additional","affiliation":[{"name":"GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Li\u00e8ge, Li\u00e8ge, Belgium"},{"name":"Walloon Excellence in Life sciences and Biotechnology (WELBIO), Wallonia, Belgium"},{"name":"Psychology and Cognitive Neuroscience Research Unit, University of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Meyer","sequence":"additional","affiliation":[{"name":"GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Li\u00e8ge, Li\u00e8ge, Belgium"},{"name":"Walloon Excellence in Life sciences and Biotechnology (WELBIO), Wallonia, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Elansary","sequence":"additional","affiliation":[{"name":"GIGA-Medical Genomics, University of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3142-2623","authenticated-orcid":false,"given":"Maxime","family":"Van Egroo","sequence":"additional","affiliation":[{"name":"GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"Chylinski","sequence":"additional","affiliation":[{"name":"GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Berthomier","sequence":"additional","affiliation":[{"name":"Physip, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Brandewinder","sequence":"additional","affiliation":[{"name":"Physip, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Mouraux","sequence":"additional","affiliation":[{"name":"GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Li\u00e8ge, Li\u00e8ge, 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