{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:22:27Z","timestamp":1790479347283,"version":"4.1.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN2682011-00001I"],"award-info":[{"award-number":["HHSN2682011-00001I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["00002I"],"award-info":[{"award-number":["00002I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["00003I"],"award-info":[{"award-number":["00003I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["00004I"],"award-info":[{"award-number":["00004I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["00005I"],"award-info":[{"award-number":["00005I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["00006I"],"award-info":[{"award-number":["00006I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["00007I"],"award-info":[{"award-number":["00007I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["00008I"],"award-info":[{"award-number":["00008I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["00009I"],"award-info":[{"award-number":["00009I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF17OC0027594"],"award-info":[{"award-number":["NNF17OC0027594"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Restless legs syndrome (RLS) is a common sensorimotor disorder, which can disrupt sleep and is thought to be caused in part by low cellular iron stores. Proton pump inhibitors (PPI) and histamine H2-receptor antagonists (H2A) are among the most commonly used drugs worldwide and show evidence of causing iron deficiency. We conducted a case\/non-case observational study of blood donors in the United States (N = 13,403; REDS-III) and Denmark (N = 50,323; Danish Blood Donor Study, DBDS), both of which had complete blood count measures and a completed RLS assessment via the Cambridge\u2013Hopkins RLS questionnaire. After adjusting for age, sex, race, BMI, blood donation frequency, smoking, hormone use, and iron supplement use, PPI\/H2A use was associated with RLS (odds ratio [OR] = 1.41; 95% confidence interval [CI], 1.13\u20131.76; p = 0.002) in REDS-III for both PPI (OR = 1.43; CI, 1.03\u20131.95; p = 0.03) and H2A (OR = 1.56; CI, 1.10\u20132.16; p = 0.01). DBDS exhibited a similar association with PPIs\/H2As (OR = 1.29; CI, 1.20\u20131.40; p &amp;lt; 0.001), and for PPIs alone (OR = 1.27; CI, 1.17\u20131.38; p &amp;lt; 0.001), but not H2As alone (OR = 1.18; CI, 0.92\u20131.53; p = 0.2). We found no evidence of blood iron stores mediating this association. The association of PPI, and possibly H2A, consumption with RLS independent of blood iron status and other factors which contribute to RLS risk suggest the need to re-evaluate use of PPI\/H2A in populations at particular risk for RLS.<\/jats:p>","DOI":"10.1093\/sleep\/zsaa220","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T14:00:53Z","timestamp":1603980053000},"source":"Crossref","is-referenced-by-count":11,"title":["Association of proton pump inhibitor and histamine H2-receptor antagonists with restless legs syndrome"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6576-1319","authenticated-orcid":false,"given":"Eric J","family":"Earley","sequence":"first","affiliation":[{"name":"RTI International, Research Triangle Park, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Didriksen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan R","family":"Spencer","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yale University, New Haven, CT"},{"name":"American Red Cross Scientific Affairs, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Pittsburgh, PA"},{"name":"Vitalant Northeast Division, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6551-6647","authenticated-orcid":false,"given":"Christian","family":"Erikstrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Aarhus University Hospital, Skejby, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole B","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Naestved Hospital, Naestved, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer S","family":"Burgdorf","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H","family":"Kleinman","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan E","family":"Mast","sequence":"additional","affiliation":[{"name":"Blood Research Institute, Versiti, Milwaukee, WI"},{"name":"Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P","family":"Busch","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of California San Francisco, CA"},{"name":"Vitalant Research Institute, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Ullum","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grier P","family":"Page","sequence":"additional","affiliation":[{"name":"RTI International, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"issue":"7","key":"2021040908524264500_CIT0001","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.sleep.2010.12.018","article-title":"Prevalence of restless legs syndrome in North American and Western European populations: a systematic review","volume":"12","author":"Innes","year":"2011","journal-title":"Sleep Med."},{"issue":"11","key":"2021040908524264500_CIT0002","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1001\/archinte.165.11.1286","article-title":"Restless legs syndrome prevalence and impact: REST general population study","volume":"165","author":"Allen","year":"2005","journal-title":"Arch Intern Med."},{"key":"2021040908524264500_CIT0003","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.sleep.2018.02.007","article-title":"Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors","volume":"45","author":"Didriksen","year":"2018","journal-title":"Sleep Med."},{"issue":"9","key":"2021040908524264500_CIT0004","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.sleep.2010.07.007","article-title":"Restless legs syndrome: understanding its consequences and the need for better treatment","volume":"11","author":"Earley","year":"2010","journal-title":"Sleep Med."},{"issue":"4","key":"2021040908524264500_CIT0005","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.smrv.2011.04.001","article-title":"Restless legs syndrome and conditions associated with metabolic dysregulation, sympathoadrenal dysfunction, and cardiovascular disease risk: a systematic review","volume":"16","author":"Innes","year":"2012","journal-title":"Sleep Med Rev."},{"issue":"Pt 4","key":"2021040908524264500_CIT0006","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/brain\/awr012","article-title":"Profile of altered brain iron acquisition in restless legs syndrome","volume":"134","author":"Connor","year":"2011","journal-title":"Brain."},{"key":"2021040908524264500_CIT0007","doi-asserted-by":"crossref","first-page":"S440","DOI":"10.1002\/mds.21607","article-title":"The role of iron in restless legs syndrome","volume":"22","author":"Allen","year":"2007","journal-title":"Mov Disord."},{"issue":"8","key":"2021040908524264500_CIT0008","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/ng2099","article-title":"Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions","volume":"39","author":"Winkelmann","year":"2007","journal-title":"Nat Genet."},{"issue":"4","key":"2021040908524264500_CIT0009","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1056\/NEJMc072518","article-title":"A genetic risk factor for periodic limb movements in sleep","volume":"358","author":"Vilarino-Guell","year":"2008","journal-title":"N Engl J Med."},{"issue":"11","key":"2021040908524264500_CIT0010","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S1474-4422(17)30327-7","article-title":"Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis","volume":"16","author":"Schormair","year":"2017","journal-title":"Lancet Neurol."},{"issue":"7","key":"2021040908524264500_CIT0011","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1056\/NEJMoa072743","article-title":"A genetic risk factor for periodic limb movements in sleep","volume":"357","author":"Stefansson","year":"2007","journal-title":"N Engl J Med."},{"issue":"1","key":"2021040908524264500_CIT0012","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/ana.22435","article-title":"Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis","volume":"70","author":"Catoire","year":"2011","journal-title":"Ann Neurol."},{"key":"2021040908524264500_CIT0013","doi-asserted-by":"crossref","first-page":"935","DOI":"10.3389\/fneur.2019.00935","article-title":"MEIS1 and restless legs syndrome: a comprehensive review","volume":"10","author":"Sarayloo","year":"2019","journal-title":"Front Neurol."},{"issue":"6","key":"2021040908524264500_CIT0014","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1007\/s00429-020-02090-x","article-title":"BTBD9 and dopaminergic dysfunction in the pathogenesis of restless legs syndrome","volume":"225","author":"Lyu","year":"2020","journal-title":"Brain Struct Funct."},{"issue":"12","key":"2021040908524264500_CIT0015","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.cub.2012.04.027","article-title":"Sleep fragmentation and motor restlessness in a Drosophila model of Restless Legs Syndrome","volume":"22","author":"Freeman","year":"2012","journal-title":"Curr Biol."},{"issue":"9","key":"2021040908524264500_CIT0016","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.sleep.2008.11.003","article-title":"Efficacy of oral iron in patients with restless legs syndrome and a low-normal ferritin: a randomized, double-blind, placebo-controlled study","volume":"10","author":"Wang","year":"2009","journal-title":"Sleep Med."},{"issue":"5","key":"2021040908524264500_CIT0017","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.3390\/nu12051313","article-title":"The effect of parenteral or oral iron supplementation on fatigue, sleep, quality of life and restless legs syndrome in iron-deficient blood donors: a secondary analysis of the ironwoman RCT","volume":"12","author":"Macher","year":"2020","journal-title":"Nutrients"},{"issue":"9","key":"2021040908524264500_CIT0018","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.sleep.2011.06.009","article-title":"Clinical efficacy and safety of IV ferric carboxymaltose (FCM) treatment of RLS: a multi-centred, placebo-controlled preliminary clinical trial","volume":"12","author":"Allen","year":"2011","journal-title":"Sleep Med."},{"key":"2021040908524264500_CIT0019","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.sleep.2016.06.021","article-title":"Clinical efficacy of ferric carboxymaltose treatment in patients with restless legs syndrome","volume":"25","author":"Cho","year":"2016","journal-title":"Sleep Med."},{"issue":"5","key":"2021040908524264500_CIT0020","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/ane.12520","article-title":"Restless legs syndrome and pregnancy: prevalence, possible pathophysiological mechanisms and treatment","volume":"133","author":"Gupta","year":"2016","journal-title":"Acta Neurol Scand."},{"issue":"4","key":"2021040908524264500_CIT0021","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.smrv.2011.08.006","article-title":"When gender matters: restless legs syndrome. Report of the \u201cRLS and woman\u201d workshop endorsed by the European RLS Study Group","volume":"16","author":"Manconi","year":"2012","journal-title":"Sleep Med Rev."},{"issue":"10110","key":"2021040908524264500_CIT0022","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1016\/S0140-6736(17)31928-1","article-title":"Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45\u2008000 donors","volume":"390","author":"Di Angelantonio","year":"2017","journal-title":"Lancet."},{"issue":"8","key":"2021040908524264500_CIT0023","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1111\/trf.12260","article-title":"Restless legs syndrome, pica, and iron status in blood donors","volume":"53","author":"Spencer","year":"2013","journal-title":"Transfusion."},{"issue":"8","key":"2021040908524264500_CIT0024","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1111\/trf.12061","article-title":"Ascertainment of iron deficiency and depletion in blood donors through screening questions for pica and restless legs syndrome","volume":"53","author":"Bryant","year":"2013","journal-title":"Transfusion."},{"key":"2021040908524264500_CIT0025","first-page":"CD007834","article-title":"Iron for restless legs syndrome","volume":"5","author":"Trotti","year":"2012","journal-title":"Cochrane Database Syst Rev."},{"issue":"2","key":"2021040908524264500_CIT0026","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1592\/phco.28.2.271","article-title":"Restless legs syndrome induced by escitalopram: case report and review of the literature","volume":"28","author":"Page","year":"2008","journal-title":"Pharmacotherapy."},{"issue":"1","key":"2021040908524264500_CIT0027","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jpsychires.2008.02.006","article-title":"Restless legs syndrome as side effect of second generation antidepressants","volume":"43","author":"Rottach","year":"2008","journal-title":"J Psychiatr Res."},{"issue":"4","key":"2021040908524264500_CIT0028","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2147\/tcrm.2006.2.4.465","article-title":"Restless leg syndrome: is it a real problem?","volume":"2","author":"Cotter","year":"2006","journal-title":"Ther Clin Risk Manag."},{"issue":"9","key":"2021040908524264500_CIT0029","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1136\/gut.2006.108613","article-title":"Proton pump inhibitors suppress absorption of dietary non-haem iron in hereditary haemochromatosis","volume":"56","author":"Hutchinson","year":"2007","journal-title":"Gut."},{"issue":"9","key":"2021040908524264500_CIT0030","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1097\/01.SMJ.0000110405.63179.69","article-title":"Effect of omeprazole on oral iron replacement in patients with iron deficiency anemia","volume":"97","author":"Sharma","year":"2004","journal-title":"South Med J."},{"issue":"2","key":"2021040908524264500_CIT0031","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/joim.12826","article-title":"Use of proton pump inhibitors and risk of iron deficiency: a population-based case-control study","volume":"285","author":"Tran-Duy","year":"2019","journal-title":"J Intern Med."},{"issue":"4","key":"2021040908524264500_CIT0032","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1053\/j.gastro.2016.11.023","article-title":"Proton pump inhibitor and histamine-2 receptor antagonist use and iron deficiency","volume":"152","author":"Lam","year":"2017","journal-title":"Gastroenterology."},{"issue":"9","key":"2021040908524264500_CIT0033","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/ajh.24784","article-title":"Estimates of total body iron indicate 19 mg and 38 mg oral iron are equivalent for the mitigation of iron deficiency in individuals experiencing repeated phlebotomy","volume":"92","author":"Bialkowski","year":"2017","journal-title":"Am J Hematol."},{"issue":"6","key":"2021040908524264500_CIT0034","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/S0016-5085(81)80013-3","article-title":"Role of gastric acid in food iron absorption","volume":"81","author":"Skikne","year":"1981","journal-title":"Gastroenterology."},{"issue":"6","key":"2021040908524264500_CIT0035","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1111\/trf.13011","article-title":"Predictors of hemoglobin in Danish blood donors: results from the Danish Blood Donor Study","volume":"55","author":"Kotz\u00e9","year":"2015","journal-title":"Transfusion."},{"issue":"5","key":"2021040908524264500_CIT0036","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1177\/1756283X16650156","article-title":"Use of proton-pump inhibitors among adults: a Danish nationwide drug utilization study","volume":"9","author":"Potteg\u00e5rd","year":"2016","journal-title":"Therap Adv Gastroenterol."},{"issue":"1","key":"2021040908524264500_CIT0037","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/trf.14971","article-title":"Blood, sweat, and tears: Red Blood Cell-Omics study objectives, design, and recruitment activities","volume":"59","author":"Endres-Dighe","year":"2019","journal-title":"Transfusion."},{"issue":"3","key":"2021040908524264500_CIT0038","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1537-2995.2010.02865.x","article-title":"Iron deficiency in blood donors: analysis of enrollment data from the REDS-II Donor Iron Status Evaluation (RISE) study","volume":"51","author":"Cable","year":"2011","journal-title":"Transfusion."},{"issue":"3","key":"2021040908524264500_CIT0039","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1423-0410.2011.01553.x","article-title":"The Danish Blood Donor Study: a large, prospective cohort and biobank for medical research","volume":"102","author":"Pedersen","year":"2012","journal-title":"Vox Sang."},{"key":"2021040908524264500_CIT0040","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cmpb.2016.07.023","article-title":"Digital questionnaire platform in the Danish Blood Donor Study","volume":"135","author":"Burgdorf","year":"2016","journal-title":"Comput Methods Programs Biomed."},{"issue":"7 Suppl","key":"2021040908524264500_CIT0041","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1403494810387965","article-title":"The Danish civil registration system","volume":"39","author":"Pedersen","year":"2011","journal-title":"Scand J Public Health."},{"issue":"10","key":"2021040908524264500_CIT0042","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.sleep.2008.10.007","article-title":"Validation of the self-completed Cambridge-Hopkins questionnaire (CH-RLSq) for ascertainment of restless legs syndrome (RLS) in a population survey","volume":"10","author":"Allen","year":"2009","journal-title":"Sleep Med."},{"issue":"12","key":"2021040908524264500_CIT0043","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.5664\/jcsm.4298","article-title":"Review of diagnostic instruments for the restless legs syndrome\/Willis-Ekbom Disease (RLS\/WED): critique and recommendations","volume":"10","author":"Walters","year":"2014","journal-title":"J Clin Sleep Med."},{"issue":"4","key":"2021040908524264500_CIT0044","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.sleep.2011.11.020","article-title":"Descriptors of restless legs syndrome sensations","volume":"13","author":"Kerr","year":"2012","journal-title":"Sleep Med."},{"issue":"7 Suppl","key":"2021040908524264500_CIT0045","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/1403494810394717","article-title":"The Danish National Prescription Registry","volume":"39","author":"Kildemoes","year":"2011","journal-title":"Scand J Public Health."},{"issue":"3","key":"2021040908524264500_CIT0046","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1182\/blood.V50.3.441.441","article-title":"Effect of blood donation on iron stores as evaluated by serum ferritin","volume":"50","author":"Finch","year":"1977","journal-title":"Blood."},{"issue":"4","key":"2021040908524264500_CIT0047","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/ajh.23397","article-title":"The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia","volume":"88","author":"Allen","year":"2013","journal-title":"Am J Hematol"},{"key":"2021040908524264500_CIT0048","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.sleep.2017.11.1126","article-title":"Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome\/Willis-Ekbom disease in adults and children: an IRLSSG task force report","volume":"41","author":"Allen","year":"2018","journal-title":"Sleep Med."},{"key":"2021040908524264500_CIT0049","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.sleep.2017.04.014","article-title":"Prevalence of restless legs syndrome and associated factors in an otherwise healthy population: results from the Danish Blood Donor Study","volume":"36","author":"Didriksen","year":"2017","journal-title":"Sleep Med."},{"issue":"1","key":"2021040908524264500_CIT0050","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12987-020-00190-8","article-title":"Evidence for communication of peripheral iron status to cerebrospinal fluid: clinical implications for therapeutic strategy","volume":"17","author":"Connor","year":"2020","journal-title":"Fluids Barriers CNS."},{"key":"2021040908524264500_CIT0051","first-page":"9394060","article-title":"Limitations of serum ferritin in diagnosing iron deficiency in inflammatory conditions","volume":"2018","author":"Dignass","year":"2018","journal-title":"Int J Chronic Dis."},{"issue":"10","key":"2021040908524264500_CIT0052","doi-asserted-by":"crossref","first-page":"e0186662","DOI":"10.1371\/journal.pone.0186662","article-title":"Associations of health status with subsequent blood donor behavior\u2014an alternative perspective on the Healthy Donor Effect from Donor InSight","volume":"12","author":"van den Hurk","year":"2017","journal-title":"PLoS One."}],"container-title":["Sleep"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/sleep\/advance-article-pdf\/doi\/10.1093\/sleep\/zsaa220\/34364302\/zsaa220.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/sleep\/article-pdf\/44\/4\/zsaa220\/36833733\/zsaa220.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/sleep\/article-pdf\/44\/4\/zsaa220\/36833733\/zsaa220.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T11:39:34Z","timestamp":1617968374000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/sleep\/article\/doi\/10.1093\/sleep\/zsaa220\/5942955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,29]]},"references-count":52,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,10,29]]},"published-print":{"date-parts":[[2021,4,9]]}},"URL":"https:\/\/doi.org\/10.1093\/sleep\/zsaa220","relation":{},"ISSN":["0161-8105","1550-9109"],"issn-type":[{"value":"0161-8105","type":"print"},{"value":"1550-9109","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,4,1]]},"published":{"date-parts":[[2020,10,29]]},"article-number":"zsaa220"}}