{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:43:30Z","timestamp":1787867010719,"version":"build-2784847793"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["81670087"],"award-info":[{"award-number":["81670087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["7174360"],"award-info":[{"award-number":["7174360"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hainan Province Science and Technology Special Fund","award":["ZDYF2020127"],"award-info":[{"award-number":["ZDYF2020127"]}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7174360"],"award-info":[{"award-number":["7174360"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","award":["16H01881"],"award-info":[{"award-number":["16H01881"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>Excessive daytime sleepiness (EDS) is a frequent cause for consultation and a defining symptom of narcolepsy and idiopathic hypersomnia (IH). The associated mechanisms remain unclear. Lipocalin-type prostaglandin D synthase (LPGDS) is a plausible sleep-inducing candidate. This study is to compare cerebral spinal fluid (CSF) and serum LPGDS levels in patients group with hypersomnia of central origin, including those with narcolepsy type 1 (NT1) and type 2 (NT2) and IH, to those in healthy controls (Con).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Serum LPGDS, CSF LPGDS, and CSF hypocretin-1(Hcrt-1) levels were measured by ELISA in 122 narcolepsy patients (106 NT1 and 16 NT2), 27 IH, and 51Con.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>LPGDS levels in CSF (p = 0.02) and serum (p &amp;lt; 0.001) were 22%\u201325% lower in control subjects than in patients with EDS complaints, including NT1, NT2, and IH. In contrast to significant differences in CSF Hcrt-1 levels, CSF L-PGDS levels and serum L-PGDS were comparable among NT1, NT2, and IH (p &amp;gt; 0.05), except for slightly lower serum LPGDS in IH than in NT1 (p = 0.01). Serum L-PGDS correlated modestly and negatively to sleep latency on MSLT (r = \u22120.227, p = 0.007) in hypersomnia subjects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>As a somnogen-producing enzyme, CSF\/serum LPGDS may serve as a new biomarker for EDS of central origin and imply a common pathogenetic association, but would complement rather than replaces orexin markers.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleep\/zsaa234","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T18:32:36Z","timestamp":1605119556000},"source":"Crossref","is-referenced-by-count":12,"title":["Lipocalin-type prostaglandin D synthase levels increase in patients with narcolepsy and idiopathic hypersomnia"],"prefix":"10.1093","volume":"44","author":[{"given":"Peipei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Peking University People\u2019s Hospital , Beijing, China"},{"name":"Sleep and Psychosomatic Medicine Center, The Third People\u2019s Hospital of Hainan Province , Sanya, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Peking University People\u2019s Hospital , Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Peking University People\u2019s Hospital , Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"An","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Peking University People\u2019s Hospital , Beijing, 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