{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:59:11Z","timestamp":1790949551772,"version":"4.1.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"6","funder":[{"DOI":"10.13039\/100008250","name":"Northwestern University Feinberg School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2TR001424"],"award-info":[{"award-number":["KL2TR001424"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001422"],"award-info":[{"award-number":["UL1TR001422"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["L30NS098427"],"award-info":[{"award-number":["L30NS098427"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23NS092975"],"award-info":[{"award-number":["K23NS092975"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01AG011412"],"award-info":[{"award-number":["P01AG011412"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cognitive impairment and disturbed sleep\u2013wake rhythms are disabling complications of liver cirrhosis, yet there is limited understanding of how they are related. We tested the hypothesis that alterations of sleep, rest-activity, and light exposure patterns are associated with worse cognition in cirrhosis. A total of 54 ambulatory adult patients with cirrhosis and 41 age-\/gender-matched healthy controls wore wrist actigraphy for rest-activity and light measurements and completed Patient-Reported Outcomes Measurement Information System sleep instruments for self-reported sleep quality. We used standard nonparametric descriptors to characterize rest-activity and light patterns, and wake after sleep onset and sleep efficiency to assess objective sleep quality. The NIH Toolbox cognition battery was used for objective cognitive evaluation using T-scores from a demographically adjusted population reference. Spearman\u2019s correlation and multivariable models were used to explore associations between measures of cognition, sleep, rest-activity, and light. Cognition was significantly impaired in cirrhosis patients. Sleep quality was worse in cirrhosis patients by subjective and objective measures compared with controls. Cirrhosis patients exhibited fragmented and dampened rest-activity rhythms, lower daytime and higher nighttime light exposure compared with controls. Worse working memory and processing speed was associated with lower daytime activity level, higher rest-activity fragmentation, lower day-to-day stability, and greater nocturnal light exposure. No association was found between cognition and sleep quality. Rest-activity fragmentation and abnormal light exposure patterns are common in patients with liver disease and are associated with the severity of cognitive impairment. Further research is needed to investigate the effects of timed bright light and exercise intervention on cognitive function in patients with liver disease.<\/jats:p>","DOI":"10.1093\/sleep\/zsaa288","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T00:36:40Z","timestamp":1608856600000},"source":"Crossref","is-referenced-by-count":22,"title":["Rest-activity rhythm disturbance in liver cirrhosis and association with cognitive impairment"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2720-1940","authenticated-orcid":false,"given":"Minjee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL"},{"name":"Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"},{"name":"Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M","family":"Liotta","sequence":"additional","affiliation":[{"name":"Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL"},{"name":"Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Chicago, IL"},{"name":"Division of Transplant, Department of Surgery, Northwestern Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1859-8357","authenticated-orcid":false,"given":"Matthew B","family":"Maas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL"},{"name":"Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9668-9866","authenticated-orcid":false,"given":"Rosemary I","family":"Braun","sequence":"additional","affiliation":[{"name":"Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"},{"name":"Biostatistics Division, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"},{"name":"Department of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blas","family":"Garcia-Canga","sequence":"additional","affiliation":[{"name":"Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R","family":"Ganger","sequence":"additional","affiliation":[{"name":"Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Chicago, IL"},{"name":"Division of Transplant, Department of Surgery, Northwestern Medicine, Chicago, IL"},{"name":"Department of Medicine, Northwestern Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela P","family":"Ladner","sequence":"additional","affiliation":[{"name":"Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Chicago, IL"},{"name":"Division of Transplant, Department of Surgery, Northwestern Medicine, Chicago, IL"},{"name":"Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn J","family":"Reid","sequence":"additional","affiliation":[{"name":"Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL"},{"name":"Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis C","family":"Zee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL"},{"name":"Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,25]]},"reference":[{"issue":"11","key":"2021061108590529800_CIT0001","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1002\/acn3.50924","article-title":"Impaired cognition predicts the risk of hospitalization and death in cirrhosis","volume":"6","author":"Kim","year":"2019","journal-title":"Ann Clin Transl Neurol."},{"issue":"11","key":"2021061108590529800_CIT0002","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1038\/ajg.2014.264","article-title":"Covert hepatic encephalopathy is independently associated with poor survival and increased risk of hospitalization","volume":"109","author":"Patidar","year":"2014","journal-title":"Am J Gastroenterol."},{"issue":"Pt 5","key":"2021061108590529800_CIT0003","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/brain\/awh129","article-title":"Disrupted daily activity\/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer\u2019s dementia","volume":"127","author":"Hatfield","year":"2004","journal-title":"Brain."},{"issue":"5","key":"2021061108590529800_CIT0004","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/ana.22468","article-title":"Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women","volume":"70","author":"Tranah","year":"2011","journal-title":"Ann Neurol."},{"issue":"11","key":"2021061108590529800_CIT0005","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1111\/jgs.15555","article-title":"Rest-activity rhythms and cognitive decline in older men: the osteoporotic fractures in men sleep study","volume":"66","author":"Rogers-Soeder","year":"2018","journal-title":"J Am Geriatr Soc."},{"issue":"22","key":"2021061108590529800_CIT0006","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1001\/jama.299.22.2642","article-title":"Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial","volume":"299","author":"Riemersma-van der Lek","year":"2008","journal-title":"JAMA."},{"issue":"7","key":"2021061108590529800_CIT0007","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.5665\/sleep.2802","article-title":"Sleep fragmentation and the risk of incident Alzheimer\u2019s disease and cognitive decline in older persons","volume":"36","author":"Lim","year":"2013","journal-title":"Sleep."},{"issue":"2","key":"2021061108590529800_CIT0008","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/hep.510270204","article-title":"High prevalence of sleep disturbance in cirrhosis","volume":"27","author":"C\u00f3rdoba","year":"1998","journal-title":"Hepatology."},{"issue":"8","key":"2021061108590529800_CIT0009","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1038\/ajg.2010.86","article-title":"On the origin and the consequences of circadian abnormalities in patients with cirrhosis","volume":"105","author":"Montagnese","year":"2010","journal-title":"Am J Gastroenterol."},{"issue":"9","key":"2021061108590529800_CIT0010","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1111\/j.1478-3231.2009.02089.x","article-title":"Night-time sleep disturbance does not correlate with neuropsychiatric impairment in patients with cirrhosis","volume":"29","author":"Montagnese","year":"2009","journal-title":"Liver Int."},{"issue":"2","key":"2021061108590529800_CIT0011","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s11011-013-9393-3","article-title":"Correlation between degree and quality of sleep disturbance and the level of neuropsychiatric impairment in patients with liver cirrhosis","volume":"28","author":"Samanta","year":"2013","journal-title":"Metab Brain Dis."},{"issue":"4","key":"2021061108590529800_CIT0012","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10072-008-0973-7","article-title":"Sleep disturbance and daytime sleepiness in patients with cirrhosis: a case control study","volume":"29","author":"Mostacci","year":"2008","journal-title":"Neurol Sci."},{"issue":"8","key":"2021061108590529800_CIT0013","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.cgh.2017.01.027","article-title":"Most individuals with advanced cirrhosis have sleep disturbances, which are associated with poor quality of life","volume":"15","author":"Ghabril","year":"2017","journal-title":"Clin Gastroenterol Hepatol."},{"issue":"12","key":"2021061108590529800_CIT0014","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1111\/liv.13525","article-title":"Abnormalities in the 24-hour rhythm of skin temperature in cirrhosis: sleep-wake and general clinical implications","volume":"37","author":"Garrido","year":"2017","journal-title":"Liver Int."},{"issue":"5","key":"2021061108590529800_CIT0015","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/S0168-8278(01)00026-5","article-title":"Neuropsychological characterization of hepatic encephalopathy","volume":"34","author":"Weissenborn","year":"2001","journal-title":"J Hepatol."},{"issue":"2","key":"2021061108590529800_CIT0016","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s11011-012-9360-4","article-title":"Excessive daytime sleepiness and hepatic encephalopathy: it is worth asking","volume":"28","author":"De Rui","year":"2013","journal-title":"Metab Brain Dis."},{"issue":"11 Suppl 3","key":"2021061108590529800_CIT0017","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1212\/WNL.0b013e3182872ded","article-title":"Cognition assessment using the NIH Toolbox","volume":"80","author":"Weintraub","year":"2013","journal-title":"Neurology."},{"issue":"1","key":"2021061108590529800_CIT0018","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1080\/15402002.2012.636266","article-title":"Development of short forms from the PROMIS\u2122 sleep disturbance and sleep-related impairment item banks","volume":"10","author":"Yu","year":"2011","journal-title":"Behav Sleep Med."},{"issue":"11","key":"2021061108590529800_CIT0019","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1093\/sleep\/30.11.1445","article-title":"Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. An American Academy of Sleep Medicine report","volume":"30","author":"Morgenthaler","year":"2007","journal-title":"Sleep."},{"issue":"9","key":"2021061108590529800_CIT0020","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.5665\/sleep.4998","article-title":"Reproducibility of a standardized actigraphy scoring algorithm for sleep in a US hispanic\/latino population","volume":"38","author":"Patel","year":"2015","journal-title":"Sleep."},{"key":"2021061108590529800_CIT0021","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.mex.2016.05.006","article-title":"\u2018nparACT\u2019 package for R: a free software tool for the non-parametric analysis of actigraphy data","volume":"3","author":"Blume","year":"2016","journal-title":"MethodsX."},{"issue":"6","key":"2021061108590529800_CIT0022","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0006-3223(90)90523-5","article-title":"Alterations in the circadian rest-activity rhythm in aging and Alzheimer\u2019s disease","volume":"27","author":"Witting","year":"1990","journal-title":"Biol Psychiatry."},{"issue":"4","key":"2021061108590529800_CIT0023","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3109\/07420529908998724","article-title":"Bright light therapy: improved sensitivity to its effects on rest-activity rhythms in Alzheimer patients by application of nonparametric methods","volume":"16","author":"Van Someren","year":"1999","journal-title":"Chronobiol Int."},{"issue":"3","key":"2021061108590529800_CIT0024","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.slsci.2014.09.013","article-title":"Nonparametric methods in actigraphy: an update","volume":"7","author":"Gon\u00e7alves","year":"2014","journal-title":"Sleep Sci."},{"issue":"4","key":"2021061108590529800_CIT0025","doi-asserted-by":"crossref","first-page":"e92251","DOI":"10.1371\/journal.pone.0092251","article-title":"Timing and intensity of light correlate with body weight in adults","volume":"9","author":"Reid","year":"2014","journal-title":"PLoS One."},{"issue":"3","key":"2021061108590529800_CIT0026","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1053\/jhep.2002.31250","article-title":"Hepatic encephalopathy\u2013definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998","volume":"35","author":"Ferenci","year":"2002","journal-title":"Hepatology."},{"issue":"10","key":"2021061108590529800_CIT0027","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJMoa0801209","article-title":"Hyponatremia and mortality among patients on the liver-transplant waiting list","volume":"359","author":"Kim","year":"2008","journal-title":"N Engl J Med."},{"issue":"5","key":"2021061108590529800_CIT0028","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/apt.13721","article-title":"Stepwise diagnosis in covert hepatic encephalopathy: critical flicker frequency and MELD-score as a first-step approach","volume":"44","author":"Greinert","year":"2016","journal-title":"Aliment Pharmacol Ther."},{"issue":"12","key":"2021061108590529800_CIT0029","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsx168","article-title":"Actigraphy-derived daily rest-activity patterns and body mass index in community-dwelling Adults","volume":"40","author":"Cespedes Feliciano","year":"2017","journal-title":"Sleep"},{"issue":"5","key":"2021061108590529800_CIT0030","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1001\/jamaneurol.2017.4719","article-title":"Circadian rest-activity pattern changes in aging and preclinical Alzheimer disease","volume":"75","author":"Musiek","year":"2018","journal-title":"JAMA Neurol."},{"key":"2021061108590529800_CIT0031","volume-title":"R: A Language and Environment for Statistical Computing: A Graduate Course in Probability","author":"R Core Team","year":"2018"},{"key":"2021061108590529800_CIT0032","volume-title":"PROSetta Stone\u00ae Analysis Report: A Rosetta Stone for Patient Reported Outcomes","author":"Choi","year":"2012"},{"issue":"1","key":"2021061108590529800_CIT0033","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jhep.2007.02.022","article-title":"Critical flicker frequency: diagnostic tool for minimal hepatic encephalopathy","volume":"47","author":"Sharma","year":"2007","journal-title":"J Hepatol."},{"key":"2021061108590529800_CIT0034","volume-title":"Psychological Testing in the Service of Disability Determination","author":"Committee on Psychological Testing IVT, for Social Security Administration Disability Determinations, Populations BotHoS, Medicine Io","year":"2015"},{"issue":"4","key":"2021061108590529800_CIT0035","doi-asserted-by":"crossref","first-page":"R136","DOI":"10.1016\/j.cub.2009.12.014","article-title":"Working memory","volume":"20","author":"Baddeley","year":"2010","journal-title":"Curr Biol."},{"issue":"22","key":"2021061108590529800_CIT0036","doi-asserted-by":"crossref","first-page":"9487","DOI":"10.1073\/pnas.0610712104","article-title":"Functional neuroimaging and behavioral correlates of capacity decline in visual short-term memory after sleep deprivation","volume":"104","author":"Chee","year":"2007","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"7","key":"2021061108590529800_CIT0037","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/sleep\/25.7.56","article-title":"The impact of moderate sleep loss on neurophysiologic signals during working-memory task performance","volume":"25","author":"Smith","year":"2002","journal-title":"Sleep."},{"issue":"4","key":"2021061108590529800_CIT0038","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1017\/S1355617711000610","article-title":"Neuropsychological effects of sleep loss: implication for neuropsychologists","volume":"17","author":"Waters","year":"2011","journal-title":"J Int Neuropsychol Soc."},{"issue":"4","key":"2021061108590529800_CIT0039","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1073\/pnas.1018375108","article-title":"Disruption of circadian clocks has ramifications for metabolism, brain, and behavior","volume":"108","author":"Karatsoreos","year":"2011","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"7","key":"2021061108590529800_CIT0040","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.psyneuen.2011.01.004","article-title":"Dim light at night provokes depression-like behaviors and reduces CA1 dendritic spine density in female hamsters","volume":"36","author":"Bedrosian","year":"2011","journal-title":"Psychoneuroendocrinology."},{"issue":"4","key":"2021061108590529800_CIT0041","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1177\/0748730412448324","article-title":"Dim nighttime light impairs cognition and provokes depressive-like responses in a diurnal rodent","volume":"27","author":"Fonken","year":"2012","journal-title":"J Biol Rhythms."},{"issue":"4","key":"2021061108590529800_CIT0042","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1136\/oemed-2013-101993","article-title":"Chronic effects of shift work on cognition: findings from the VISAT longitudinal study","volume":"72","author":"Marqui\u00e9","year":"2015","journal-title":"Occup Environ Med."},{"issue":"10","key":"2021061108590529800_CIT0043","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1080\/00140130500241670","article-title":"Shiftwork experience, age and cognitive performance","volume":"48","author":"Rouch","year":"2005","journal-title":"Ergonomics."},{"issue":"19","key":"2021061108590529800_CIT0044","doi-asserted-by":"crossref","first-page":"7156","DOI":"10.3390\/ijerph17197156","article-title":"The effects of circadian rhythm disruption on mental health and physiological responses among shift workers and general population","volume":"17","author":"Ahmad","year":"2020","journal-title":"Int J Environ Res Public Health"},{"issue":"2","key":"2021061108590529800_CIT0045","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s10608-011-9425-4","article-title":"Habitual sleep, reasoning, and processing speed in older adults with sleep complaints","volume":"36","author":"McCrae","year":"2012","journal-title":"Cognit Ther Res."},{"issue":"8","key":"2021061108590529800_CIT0046","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.cgh.2017.01.027","article-title":"Most individuals with advanced cirrhosis have sleep disturbances, which are associated with poor quality of life","volume":"15","author":"Ghabril","year":"2017","journal-title":"Clin Gastroenterol Hepatol."},{"issue":"1\u20132","key":"2021061108590529800_CIT0047","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0006-8993(91)91209-J","article-title":"Portacaval anastomosis disrupts circadian locomotor activity and pineal melatonin rhythms in rats","volume":"560","author":"Zee","year":"1991","journal-title":"Brain Res."},{"issue":"3","key":"2021061108590529800_CIT0048","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1210\/jc.2004-0957","article-title":"High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light","volume":"90","author":"Cajochen","year":"2005","journal-title":"J Clin Endocrinol Metab."},{"key":"2021061108590529800_CIT0049","first-page":"261","article-title":"An action spectrum for melatonin suppression: evidence for a novel non-rod, non-cone photoreceptor system in humans","volume-title":"J Physiol.","author":"Thapan","year":"2001"},{"issue":"1","key":"2021061108590529800_CIT0050","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1177\/0748730418821776","article-title":"The phase-shifting effect of bright light exposure on circadian rhythmicity in the human transcriptome","volume":"34","author":"Kervezee","year":"2019","journal-title":"J Biol Rhythms."},{"issue":"7","key":"2021061108590529800_CIT0051","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.cell.2018.04.014","article-title":"Moderate UV exposure enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the brain","volume":"173","author":"Zhu","year":"2018","journal-title":"Cell."},{"issue":"5","key":"2021061108590529800_CIT0052","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1210\/jcem-54-5-1025","article-title":"Melatonin serum levels and metabolic clearance rate in patients with liver cirrhosis","volume":"54","author":"Iguchi","year":"1982","journal-title":"J Clin Endocrinol Metab."}],"container-title":["Sleep"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/sleep\/advance-article-pdf\/doi\/10.1093\/sleep\/zsaa288\/35929347\/zsaa288.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/sleep\/article-pdf\/44\/6\/zsaa288\/38574511\/zsaa288.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/sleep\/article-pdf\/44\/6\/zsaa288\/38574511\/zsaa288.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T05:06:50Z","timestamp":1623388010000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/sleep\/article\/doi\/10.1093\/sleep\/zsaa288\/6047598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,25]]},"references-count":52,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,12,25]]},"published-print":{"date-parts":[[2021,6,11]]}},"URL":"https:\/\/doi.org\/10.1093\/sleep\/zsaa288","relation":{},"ISSN":["0161-8105","1550-9109"],"issn-type":[{"value":"0161-8105","type":"print"},{"value":"1550-9109","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,6,1]]},"published":{"date-parts":[[2020,12,25]]},"article-number":"zsaa288"}}