{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:25:14Z","timestamp":1779186314769,"version":"3.51.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T00:00:00Z","timestamp":1609632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pediatric type 1 narcolepsy (NT1) is often associated with overweight and obesity. Sodium oxybate (SO), approved for the treatment of narcolepsy with cataplexy from the age of 7 years old in the United States, has been associated with weight loss, although longitudinal pediatric studies are lacking. We report a retrospective cohort of 129 consecutive patients with a 4-year follow-up, to analyze the impact of different pharmacological treatments on body mass index (BMI) z-score. At baseline, the prevalence of obesity and overweight was 26.4% (34\/129) and 29.5% (38\/129), respectively. Patients were divided into three groups: children treated with SO alone (group 1), with SO-combined therapy (group 2), and without SO (group 3). At the end of the first year of follow-up, group 1 and group 2 showed a significant BMI z-score reduction compared to baseline: from 1.2 \u00b1 1.1 to 0.4 \u00b1 1.4 for group 1 (p &amp;lt; 0.001), and from 1.4 \u00b1 1.1 to 1 \u00b1 1.3 for group 2 (p = 0.002), independently from baseline clinical features. In the second year, only group 2 experienced a further and significant BMI z-score decrease (from 1.0 \u00b1 1.2 to 0.6 \u00b1 1.2, p = 0.037). No further significant BMI z-score changes were observed in SO-treated patients in the following years. Instead, children treated without SO developed a significant weight increase between the second and third year of therapy (BMI z-score from 0.3 \u00b1 0.9 to 0.5 \u00b1 0.9). In conclusion, SO treatment in pediatric NT1 is associated with a favorable weight reduction in the first year of treatment.<\/jats:p>","DOI":"10.1093\/sleep\/zsaa295","type":"journal-article","created":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T11:20:05Z","timestamp":1609672805000},"source":"Crossref","is-referenced-by-count":16,"title":["BMI changes in pediatric type 1 narcolepsy under sodium oxybate treatment"],"prefix":"10.1093","volume":"44","author":[{"given":"Virginia","family":"Ponziani","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Sant\u2019Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Pizza","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy"},{"name":"IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Zenesini","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9051-7091","authenticated-orcid":false,"given":"Luca","family":"Vignatelli","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Pession","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sant\u2019Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6937-3065","authenticated-orcid":false,"given":"Giuseppe","family":"Plazzi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche, Bologna, 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