{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:41:50Z","timestamp":1782996110985,"version":"3.54.5"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Ente Ospedaliero Cantonale"},{"name":"Swiss MS Society"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>To assess the frequency of restless legs syndrome (RLS), periodic limb movements during sleep (PLMS), and their overlap in a large sample of patients with multiple sclerosis (MS). To compare clinical and paraclinical findings among four subgroups of patients: RLS\u2212\/PLMS\u2212 (patients without RLS and PLMS), RLS+\/PLMS\u2212 (patients with RLS and without PLMS), RLS\u2212\/PLMS (patients without RLS and with PLMS), and RLS+\/PLMS+ (patients with both RLS and PLMS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this cross-sectional, observational, instrumental study, 86 patients (M\/F: 27\/59; mean age 48.0 \u00b1 10.8 years) with a diagnosis of MS underwent a telephone interview assessing the five standard diagnostic criteria for RLS. Seventy-six participants underwent polysomnography (PSG) and maintenance of wakefulness test (MWT). Instrumental and clinical findings were subsequently statistically compared to investigate their association with RLS and PLMS index (PLMSI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>RLS and PLMS (PLMSI \u226515\/h) frequency in patients with MS were of 31.4% and 31.6%, respectively. Among patients with RLS, 37.5% had a PLMSI of at least 15\/h. RLS\u2212\/PLMS+ group showed higher wake after sleep onset (p = 0.01), stage shifts per hour (p = 0.03), increased stage N1 (p = 0.03), and reduction in stage N3 (p = 0.01) compared to RLS\u2212\/PLMS\u2212. RLS had no influence on clinical and PSG parameters (p = 0.45).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>RLS is highly frequent in patients with MS. The frequency of PLMS is comparable to the general population. The low percentage of patients with RLS having a high PLMSI, together with the absence of correlation between RLS and female gender and older age, supports the existence of a distinct symptomatic form of RLS in MS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleep\/zsab066","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T14:23:23Z","timestamp":1615818203000},"source":"Crossref","is-referenced-by-count":12,"title":["Restless legs syndrome and periodic limb movements in 86 patients with multiple sclerosis"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6190-1633","authenticated-orcid":false,"given":"Davide","family":"Sparasci","sequence":"first","affiliation":[{"name":"Sleep Medicine Unit, Neurocenter of Southern Switzerland, Ospedale Civico , Lugano , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6937-3065","authenticated-orcid":false,"given":"Raffaele","family":"Ferri","sequence":"additional","affiliation":[{"name":"Sleep Research Centre; 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