{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:17:52Z","timestamp":1792135072153,"version":"4.4.0"},"reference-count":106,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T00:00:00Z","timestamp":1618012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MRC and Stroke Association","award":["MR\/S001948"],"award-info":[{"award-number":["MR\/S001948"]}]},{"DOI":"10.13039\/501100004789","name":"John Fell OUP Research Fund","doi-asserted-by":"publisher","award":["131\/032"],"award-info":[{"award-number":["131\/032"]}],"id":[{"id":"10.13039\/501100004789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study Objectives<\/jats:title>\n                    <jats:p>Torpor is a regulated and reversible state of metabolic suppression used by many mammalian species to conserve energy. Whereas the relationship between torpor and sleep has been well-studied in seasonal hibernators, less is known about the effects of fasting-induced torpor on states of vigilance and brain activity in laboratory mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Continuous monitoring of electroencephalogram (EEG), electromyogram (EMG), and surface body temperature was undertaken in adult, male C57BL\/6 mice over consecutive days of scheduled restricted feeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All animals showed bouts of hypothermia that became progressively deeper and longer as fasting progressed. EEG and EMG were markedly affected by hypothermia, although the typical electrophysiological signatures of non-rapid eye movement (NREM) sleep, rapid eye movement (REM) sleep, and wakefulness enabled us to perform vigilance-state classification in all cases. Consistent with previous studies, hypothermic bouts were initiated from a state indistinguishable from NREM sleep, with EEG power decreasing gradually in parallel with decreasing surface body temperature. During deep hypothermia, REM sleep was largely abolished, and we observed shivering-associated intense bursts of muscle activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study highlights important similarities between EEG signatures of fasting-induced torpor in mice, daily torpor in Djungarian hamsters and hibernation in seasonally hibernating species. Future studies are necessary to clarify the effects on fasting-induced torpor on subsequent sleep.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleep\/zsab093","type":"journal-article","created":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T14:42:21Z","timestamp":1618065741000},"source":"Crossref","is-referenced-by-count":35,"title":["The relationship between fasting-induced torpor, sleep, and wakefulness in laboratory mice"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1034-1517","authenticated-orcid":false,"given":"Yi-Ge","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Physiology, Anatomy and Genetics, University of Oxford , Parks Road, Oxford, OX1 3PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J","family":"Flaherty","sequence":"additional","affiliation":[{"name":"Department of Physiology, Anatomy and Genetics, University of Oxford , Parks Road, Oxford, OX1 3PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina A","family":"Pothecary","sequence":"additional","affiliation":[{"name":"Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology , South Parks Road, Oxford OX1 3RE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell G","family":"Foster","sequence":"additional","affiliation":[{"name":"Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology , South Parks Road, Oxford OX1 3RE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3653-834X","authenticated-orcid":false,"given":"Stuart N","family":"Peirson","sequence":"additional","affiliation":[{"name":"Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical 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