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Cerebrospinal fluid was collected for amyloid-beta, total-tau, and phospho-tau levels determination. Also, overnight polysomnography was performed, followed by neuropsychological evaluations at baseline and after 12 months of follow-up. Principal component analysis revealed two profiles of patients in terms of sleep: one with a propensity to deepen the sleep (deep sleepers) and the other with a propensity to spend most of the time in the lighter sleep stage (light sleepers).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort included 125 patients with a median [IQR] of 75.0 [72.0;80.0] years. Deep and light sleepers did not present differences in relation to the cerebrospinal fluid pathological markers and to the cognitive function at the baseline. However, there was a significant difference of \u22121.51 (95% CI: \u22122.43 to \u22120.59) in the Mini-mental state examination after 12 months of follow-up. Accordingly, sleep depth and cognitive decline presented a dose\u2013response relationship (p-for-trend\u2005=\u20050.02). Similar outcomes were observed in relation to the processing speed (Stroop words test, p-value\u2005=\u20050.016) and to the executive function (Verbal fluency test, p-value\u2005=\u20050.023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Considering the increased cognitive decline presented by light sleepers, the sleep profile may have a predictive role in relation to the cognitive function of patients with mild-moderate Alzheimer\u2019s disease. The modifiable nature of sleep sets this behavior as a possible useful intervention to prevent a marked cognitive decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Information<\/jats:title><jats:p>Role of Hypoxia Ans Sleep Fragmentation in Alzheimer\u2019s Disease. and Sleep Fragmentation. Completed. NCT02814045<\/jats:p><\/jats:sec>","DOI":"10.1093\/sleep\/zsab117","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T05:47:56Z","timestamp":1620625676000},"source":"Crossref","is-referenced-by-count":21,"title":["Sleep profile predicts the cognitive decline of mild-moderate Alzheimer\u2019s disease patients"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7577-7661","authenticated-orcid":false,"given":"Adriano D S","family":"Targa","sequence":"first","affiliation":[{"name":"Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova-Santa Maria , IRBLleida, Lleida , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias (CIBERES) , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3558-5948","authenticated-orcid":false,"given":"Iv\u00e1n 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