{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:23:20Z","timestamp":1790846600649,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T00:00:00Z","timestamp":1625875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"French National Centre for Scientific Research","award":["UMR5292"],"award-info":[{"award-number":["UMR5292"]}]},{"DOI":"10.13039\/501100001677","name":"National Institute of Health and Medical Research","doi-asserted-by":"publisher","award":["U1028"],"award-info":[{"award-number":["U1028"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>Determine whether in the hippocampus and the supramammillary nucleus (SuM) the same neurons are reactivated when mice are exposed 1 week apart to two periods of wakefulness (W-W), paradoxical sleep rebound (PSR-PSR) or a period of W followed by a period of PSR (W-PSR)<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We combined the innovative TRAP2 mice method in which neurons expressing cFos permanently express tdTomato after tamoxifen injection with cFos immunohistochemistry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found out that a large number of tdTomato+ and cFos+ cells are localized in the dentate gyrus (DG) after PSR and W while CA1 and CA3 contained both types of neurons only after W. The number of cFos+ cells in the infrapyramidal but not the suprapyramidal blade of the DG was positively correlated with the amount of PS. In addition, we did not find double-labeled cells in the DG whatever the group of mice. In contrast, a high percentage of CA1 neurons were double-labeled in W-W mice. Finally, in the supramammillary nucleus, a large number of cells were double-labeled in W-W, PSR-PSR but not in W-PSR mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Altogether, our results are the first to show that different neurons are activated during W and PS in the supramammillary nucleus and the hippocampus. Further, we showed for the first time that granule cells of the infrapyramidal blade of the DG are activated during PS but not during W. Further experiments are now needed to determine whether these granule cells belong to memory engrams inducing memory reactivation during PS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleep\/zsab173","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T15:31:02Z","timestamp":1625931062000},"source":"Crossref","is-referenced-by-count":11,"title":["Granule cells in the infrapyramidal blade of the dentate gyrus are activated during paradoxical (REM) sleep hypersomnia but not during wakefulness: a study using TRAP mice"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9717-6763","authenticated-orcid":false,"given":"Risa","family":"Yamazaki","sequence":"first","affiliation":[{"name":"Team \u201cSLEEP\u201d, Centre de Recherche en Neurosciences de Lyon (CRNL), UMR 5292 CNRS\/U1028 INSERM and Universit\u00e9 de Lyon , Bron , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianru","family":"Wang","sequence":"additional","affiliation":[{"name":"Team \u201cSLEEP\u201d, Centre de Recherche en Neurosciences de Lyon (CRNL), UMR 5292 CNRS\/U1028 INSERM and Universit\u00e9 de Lyon , Bron , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"De Laet","sequence":"additional","affiliation":[{"name":"Team \u201cSLEEP\u201d, Centre de Recherche en Neurosciences de Lyon (CRNL), UMR 5292 CNRS\/U1028 INSERM and Universit\u00e9 de Lyon , Bron , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Maciel","sequence":"additional","affiliation":[{"name":"Team \u201cSLEEP\u201d, Centre de Recherche en Neurosciences de Lyon (CRNL), UMR 5292 CNRS\/U1028 INSERM and Universit\u00e9 de Lyon , Bron , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Agnorelli","sequence":"additional","affiliation":[{"name":"Team \u201cSLEEP\u201d, Centre de Recherche en Neurosciences de Lyon (CRNL), UMR 5292 CNRS\/U1028 INSERM and Universit\u00e9 de Lyon , Bron , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Team \u201cSLEEP\u201d, Centre de Recherche en Neurosciences de Lyon (CRNL), UMR 5292 CNRS\/U1028 INSERM and Universit\u00e9 de Lyon , Bron , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Arthaud","sequence":"additional","affiliation":[{"name":"Team \u201cSLEEP\u201d, Centre de Recherche en Neurosciences de Lyon (CRNL), UMR 5292 CNRS\/U1028 INSERM and Universit\u00e9 de Lyon , Bron , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul-Antoine","family":"Libourel","sequence":"additional","affiliation":[{"name":"Team \u201cSLEEP\u201d, Centre de Recherche en Neurosciences de Lyon (CRNL), UMR 5292 CNRS\/U1028 INSERM and Universit\u00e9 de Lyon , Bron , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1211-8631","authenticated-orcid":false,"given":"Patrice","family":"Fort","sequence":"additional","affiliation":[{"name":"Team \u201cSLEEP\u201d, Centre de Recherche en Neurosciences de Lyon (CRNL), UMR 5292 CNRS\/U1028 INSERM and Universit\u00e9 de Lyon , Bron , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunsook","family":"Lee","sequence":"additional","affiliation":[{"name":"Team \u201cSLEEP\u201d, Centre de Recherche en Neurosciences de Lyon (CRNL), UMR 5292 CNRS\/U1028 INSERM and Universit\u00e9 de Lyon , Bron , France"},{"name":"Department of Anatomy and Research Institute of Medical Science, School of Medicine, Konkuk University , Seoul , South Korea"},{"name":"Research Institute of Medical Science, School of Medicine, Konkuk University , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Herv\u00e9","family":"Luppi","sequence":"additional","affiliation":[{"name":"Team \u201cSLEEP\u201d, Centre de Recherche en Neurosciences de Lyon (CRNL), UMR 5292 CNRS\/U1028 INSERM and Universit\u00e9 de Lyon , Bron , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,7,10]]},"reference":[{"issue":"3","key":"2022092917591708100_CIT0001","first-page":"422","article-title":"Electromyographic correlations of sleep in the chronic decorticate & mesencephalic cat","volume":"153","author":"Jouvet","year":"1959","journal-title":"C R Seances Soc Biol Fil."},{"issue":"3","key":"2022092917591708100_CIT0002","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0896-6273(02)00586-X","article-title":"Theta oscillations in the hippocampus","volume":"33","author":"Buzs\u00e1ki","year":"2002","journal-title":"Neuron."},{"issue":"26","key":"2022092917591708100_CIT0003","doi-asserted-by":"crossref","first-page":"6731","DOI":"10.1523\/JNEUROSCI.1227-08.2008","article-title":"Theta and gamma coordination of hippocampal networks during waking and rapid eye movement sleep","volume":"28","author":"Montgomery","year":"2008","journal-title":"J Neurosci."},{"issue":"3","key":"2022092917591708100_CIT0004","doi-asserted-by":"crossref","first-page":"e1400177","DOI":"10.1126\/sciadv.1400177","article-title":"The supramammillary nucleus and the claustrum activate the cortex during REM sleep","volume":"1","author":"Renouard","year":"2015","journal-title":"Sci Adv."},{"issue":"3","key":"2022092917591708100_CIT0005","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s00429-016-1289-7","article-title":"Differential origin of the activation of dorsal and ventral dentate gyrus granule cells during paradoxical (REM) sleep in the rat","volume":"222","author":"Billwiller","year":"2017","journal-title":"Brain Struct Funct."},{"issue":"5","key":"2022092917591708100_CIT0006","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.neuron.2013.03.025","article-title":"Permanent genetic access to transiently active neurons via TRAP: targeted recombination in active populations","volume":"78","author":"Guenthner","year":"2013","journal-title":"Neuron."},{"issue":"6356","key":"2022092917591708100_CIT0007","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1126\/science.aan6747","article-title":"Thirst-associated preoptic neurons encode an aversive motivational drive","volume":"357","author":"Allen","year":"2017","journal-title":"Science."},{"issue":"3","key":"2022092917591708100_CIT0008","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41593-018-0318-7","article-title":"Temporal evolution of cortical ensembles promoting remote memory retrieval","volume":"22","author":"DeNardo","year":"2019","journal-title":"Nat Neurosci."},{"issue":"6","key":"2022092917591708100_CIT0009","doi-asserted-by":"crossref","first-page":"e12976","DOI":"10.1111\/jsr.12976","article-title":"Targeted recombination in active populations as a new mouse genetic model to study sleep-active neuronal populations: demonstration that Lhx6+ neurons in the ventral zona incerta are activated during paradoxical sleep hypersomnia","volume":"29","author":"Lee","year":"2020","journal-title":"J Sleep Res."},{"issue":"5","key":"2022092917591708100_CIT0010","doi-asserted-by":"crossref","first-page":"815","DOI":"10.5665\/sleep.4682","article-title":"Unsupervised online classifier in sleep scoring for sleep deprivation studies","volume":"38","author":"Libourel","year":"2015","journal-title":"Sleep."},{"key":"2022092917591708100_CIT0011","doi-asserted-by":"crossref","first-page":"zsaa003","DOI":"10.1093\/sleep\/zsaa003","article-title":"Insights into paradoxical (REM) sleep homeostatic regulation in mice using an innovative automated sleep deprivation method","volume":"43","author":"Arthaud","year":"2020","journal-title":"Sleep"},{"issue":"3","key":"2022092917591708100_CIT0012","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/jsr.12269","article-title":"Paradoxical (REM) sleep deprivation in mice using the small-platforms-over-water method: polysomnographic analyses and melanin-concentrating hormone and hypocretin\/orexin neuronal activation before, during and after deprivation","volume":"24","author":"Arthaud","year":"2015","journal-title":"J Sleep Res."},{"issue":"10","key":"2022092917591708100_CIT0013","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1046\/j.1460-9568.2002.02257.x","article-title":"The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical study","volume":"16","author":"Boissard","year":"2002","journal-title":"Eur J Neurosci."},{"key":"2022092917591708100_CIT0014","doi-asserted-by":"crossref","DOI":"10.5772\/intechopen.71165","article-title":"A role for the longitudinal axis of the hippocampus in multiscale representations of large and complex spatial environments and mnemonic hierarchies","author":"Harland","year":"2018","journal-title":"The Hippocampus-Plasticity and Functions: IntechOpen"},{"issue":"9","key":"2022092917591708100_CIT0015","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1523\/JNEUROSCI.22-09-03520.2002","article-title":"Clonal architecture of the mouse hippocampus","volume":"22","author":"Martin","year":"2002","journal-title":"J Neurosci."},{"key":"2022092917591708100_CIT0016","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2147\/NSS.S140621","article-title":"Relevance of deprivation studies in understanding rapid eye movement sleep","volume":"10","author":"Mehta","year":"2018","journal-title":"Nat Sci Sleep."},{"issue":"7394","key":"2022092917591708100_CIT0017","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nature11028","article-title":"Optogenetic stimulation of a hippocampal engram activates fear memory recall","volume":"484","author":"Liu","year":"2012","journal-title":"Nature."},{"key":"2022092917591708100_CIT0018","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.conb.2017.05.014","article-title":"Genetic strategies to access activated neurons","volume":"45","author":"DeNardo","year":"2017","journal-title":"Curr Opin Neurobiol."},{"key":"2022092917591708100_CIT0019","doi-asserted-by":"crossref","first-page":"e00312","DOI":"10.7554\/eLife.00312","article-title":"Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice","volume":"2","author":"Deng","year":"2013","journal-title":"Elife."},{"key":"2022092917591708100_CIT0020","article-title":"Is REM sleep a paradoxical state?: different neurons are activated in the cingulate cortices and the claustrum during wakefulness and paradoxical sleep hypersomnia","volume":"114514","author":"Maciel","year":"2021","journal-title":"Biochem Pharmacol"},{"issue":"4","key":"2022092917591708100_CIT0021","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/sleep\/34.4.419","article-title":"Evidence that neurons of the sublaterodorsal tegmental nucleus triggering paradoxical (REM) sleep are glutamatergic","volume":"34","author":"Cl\u00e9ment","year":"2011","journal-title":"Sleep."},{"issue":"2","key":"2022092917591708100_CIT0022","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/brain\/aww310","article-title":"Genetic inactivation of glutamate neurons in the rat sublaterodorsal tegmental nucleus recapitulates REM sleep behaviour disorder","volume":"140","author":"Valencia Garcia","year":"2017","journal-title":"Brain."},{"issue":"9","key":"2022092917591708100_CIT0023","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1007\/s00429-020-02146-y","article-title":"GABA-glutamate supramammillary neurons control theta and gamma oscillations in the dentate gyrus during paradoxical (REM) sleep","volume":"225","author":"Billwiller","year":"2020","journal-title":"Brain Struct Funct."},{"issue":"1","key":"2022092917591708100_CIT0024","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/s41467-017-01004-6","article-title":"Supramammillary glutamate neurons are a key node of the arousal system","volume":"8","author":"Pedersen","year":"2017","journal-title":"Nat Commun."},{"issue":"5","key":"2022092917591708100_CIT0025","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/hipo.20091","article-title":"Sparse, environmentally selective expression of Arc RNA in the upper blade of the rodent fascia dentata by brief spatial experience","volume":"15","author":"Chawla","year":"2005","journal-title":"Hippocampus."},{"issue":"2","key":"2022092917591708100_CIT0026","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/hipo.22820","article-title":"Behavior-driven arc expression is reduced in all ventral hippocampal subfields compared to CA1, CA3, and dentate gyrus in rat dorsal hippocampus","volume":"28","author":"Chawla","year":"2018","journal-title":"Hippocampus."},{"key":"2022092917591708100_CIT0027","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fnbeh.2011.00048","article-title":"Contribution of Egr1\/zif268 to activity-dependent Arc\/Arg3.1 transcription in the dentate gyrus and area CA1 of the hippocampus","volume":"5","author":"Penke","year":"2011","journal-title":"Front Behav Neurosci."},{"issue":"7","key":"2022092917591708100_CIT0028","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/syn.21900","article-title":"Distinct dendritic morphology across the blades of the rodent dentate gyrus","volume":"70","author":"Gallitano","year":"2016","journal-title":"Synapse."},{"issue":"4","key":"2022092917591708100_CIT0029","doi-asserted-by":"crossref","first-page":"107551","DOI":"10.1016\/j.celrep.2020.107551","article-title":"A sparse, spatially biased subtype of mature granule cell dominates recruitment in hippocampal-associated behaviors","volume":"31","author":"Erwin","year":"2020","journal-title":"Cell Rep."},{"issue":"4","key":"2022092917591708100_CIT0030","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/hipo.20525","article-title":"Anatomical gradients of adult neurogenesis and activity: young neurons in the ventral dentate gyrus are activated by water maze training","volume":"19","author":"Snyder","year":"2009","journal-title":"Hippocampus."},{"issue":"3","key":"2022092917591708100_CIT0031","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.neuron.2020.05.008","article-title":"Sparse activity of hippocampal adult-born neurons during REM sleep is necessary for memory consolidation","volume":"107","author":"Kumar","year":"2020","journal-title":"Neuron."},{"issue":"2","key":"2022092917591708100_CIT0032","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1037\/0033-295X.99.2.195","article-title":"Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans","volume":"99","author":"Squire","year":"1992","journal-title":"Psychol Rev."},{"issue":"2","key":"2022092917591708100_CIT0033","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/PL00005753","article-title":"Organization of the entorhinal projection to the rat dentate gyrus revealed by Dil anterograde labeling","volume":"116","author":"Tamamaki","year":"1997","journal-title":"Exp Brain Res."},{"issue":"1","key":"2022092917591708100_CIT0034","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0006-8993(71)90358-1","article-title":"The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat","volume":"34","author":"O\u2019Keefe","year":"1971","journal-title":"Brain Res."},{"issue":"7","key":"2022092917591708100_CIT0035","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1523\/JNEUROSCI.07-07-01935.1987","article-title":"Spatial firing patterns of hippocampal complex-spike cells in a fixed environment","volume":"7","author":"Muller","year":"1987","journal-title":"J Neurosci."},{"issue":"9","key":"2022092917591708100_CIT0036","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/hipo.20208","article-title":"Hippocampal place cells, context, and episodic memory","volume":"16","author":"Smith","year":"2006","journal-title":"Hippocampus."},{"key":"2022092917591708100_CIT0037","doi-asserted-by":"crossref","first-page":"e00321","DOI":"10.7554\/eLife.00321","article-title":"Hierarchical organization of context in the hippocampal episodic code","volume":"2","author":"Takahashi","year":"2013","journal-title":"Elife."},{"key":"2022092917591708100_CIT0038","doi-asserted-by":"crossref","first-page":"e08105","DOI":"10.7554\/eLife.08105","article-title":"Episodic-like memory trace in awake replay of hippocampal place cell activity sequences","volume":"4","author":"Takahashi","year":"2015","journal-title":"Elife."},{"issue":"6400","key":"2022092917591708100_CIT0039","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1126\/science.aat5397","article-title":"The hippocampal engram maps experience but not place","volume":"361","author":"Tanaka","year":"2018","journal-title":"Science."},{"issue":"2","key":"2022092917591708100_CIT0040","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cub.2012.11.019","article-title":"Reactivation of neural ensembles during the retrieval of recent and remote memory","volume":"23","author":"Tayler","year":"2013","journal-title":"Curr Biol."},{"issue":"6307","key":"2022092917591708100_CIT0041","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1126\/science.aaf7003","article-title":"Ventral CA1 neurons store social memory","volume":"353","author":"Okuyama","year":"2016","journal-title":"Science."},{"issue":"1","key":"2022092917591708100_CIT0042","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0896-6273(01)00186-6","article-title":"Temporally structured replay of awake hippocampal ensemble activity during rapid eye movement sleep","volume":"29","author":"Louie","year":"2001","journal-title":"Neuron."},{"issue":"1","key":"2022092917591708100_CIT0043","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.neuron.2014.05.018","article-title":"Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis","volume":"83","author":"Denny","year":"2014","journal-title":"Neuron."},{"issue":"6","key":"2022092917591708100_CIT0044","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/hipo.22556","article-title":"Improved specificity of hippocampal memory trace labeling","volume":"26","author":"Cazzulino","year":"2016","journal-title":"Hippocampus."},{"issue":"10","key":"2022092917591708100_CIT0045","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1016\/j.celrep.2018.11.016","article-title":"Supramammillary nucleus afferents to the dentate gyrus co-release glutamate and GABA and potentiate granule cell output","volume":"25","author":"Hashimotodani","year":"2018","journal-title":"Cell Rep."},{"key":"2022092917591708100_CIT0046","doi-asserted-by":"crossref","first-page":"e53129","DOI":"10.7554\/eLife.53129","article-title":"Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release","volume":"9","author":"Li","year":"2020","journal-title":"Elife"}],"container-title":["Sleep"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/sleep\/advance-article-pdf\/doi\/10.1093\/sleep\/zsab173\/39596953\/zsab173.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/sleep\/article-pdf\/44\/12\/zsab173\/46202834\/zsab173.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/sleep\/article-pdf\/44\/12\/zsab173\/46202834\/zsab173.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T18:03:10Z","timestamp":1664474590000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/sleep\/article\/doi\/10.1093\/sleep\/zsab173\/6318825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,10]]},"references-count":46,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,7,10]]},"published-print":{"date-parts":[[2021,12,10]]}},"URL":"https:\/\/doi.org\/10.1093\/sleep\/zsab173","relation":{},"ISSN":["0161-8105","1550-9109"],"issn-type":[{"value":"0161-8105","type":"print"},{"value":"1550-9109","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,12,1]]},"published":{"date-parts":[[2021,7,10]]},"article-number":"zsab173"}}