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However, the extent and pattern of abnormal connectivity were inconsistent across studies, and cerebrocerebellar connections have been rarely assessed. We investigated functional network changes in cerebral and cerebellar cortices of OSA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Resting-state functional MRI, polysomnography, and neuropsychological (NP) test data were acquired from 74 OSA patients (age: 45.8 \u00b1 10.7 years) and 33 healthy subjects (39.6 \u00b1 9.3 years). Connectivity matrices were extracted by computing correlation coefficients from various regions of interest, and Fisher r-to-z transformations. In the functional connections that showed significant group differences, linear regression was conducted to examine the association between connectivity and clinical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with OSA showed reduced functional connectivity (FC) in cerebrocerebellar connections linking different functional networks, and greater FC in cortical between-network connections in prefrontal regions involving the default mode network (DMN) and the control network. For OSA group, we found no correlation between FC and sleep parameters including lowest SaO2 and arousal index in the connections where significant associations were observed in healthy subjects. FC changes in DMN areas were related to reduced verbal fluency in OSA. Lower local efficiency and lower clustering coefficient of the salience network in the left cerebellum were also observed in OSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>OSA affects mainly the cerebrocerebellar pathway. The disruption of function in these connections are related to sleep fragmentation and hypoxia during sleep. These abnormal network functions, especially DMN, are suggested to participate in cognitive decline of OSA.<\/jats:p><\/jats:sec>","DOI":"10.1093\/sleep\/zsab209","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T13:50:13Z","timestamp":1629899413000},"source":"Crossref","is-referenced-by-count":42,"title":["Altered cerebrocerebellar functional connectivity in patients with obstructive sleep apnea and its association with cognitive function"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7152-0754","authenticated-orcid":false,"given":"Hea Ree","family":"Park","sequence":"first","affiliation":[{"name":"Department of Neurology, Inje University College of Medicine, Ilsan Paik Hospital , Goyang , Republic of 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Neuropsychol."},{"issue":"5","key":"2023031316284420400_","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1038\/nprot.2006.390","article-title":"Administration and interpretation of the trail making test","volume":"1","author":"Bowie","year":"2006","journal-title":"Nat Protoc."},{"key":"2023031316284420400_","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3389\/fpsyg.2017.00557","article-title":"The stroop color and word test","volume":"8","author":"Scarpina","year":"2017","journal-title":"Front Psychol."},{"issue":"4","key":"2023031316284420400_","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.acn.2007.01.026","article-title":"The reliability and validity of qualitative scores for the controlled oral word association test","volume":"22","author":"Ross","year":"2007","journal-title":"Arch Clin Neuropsychol."},{"issue":"3","key":"2023031316284420400_","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1076\/clin.13.3.365.1740","article-title":"Normative study of the Korean-California Verbal Learning Test (K-CVLT)","volume":"13","author":"Kim","year":"1999","journal-title":"Clin Neuropsychol."},{"issue":"1","key":"2023031316284420400_","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1037\/0022-006X.56.1.123","article-title":"Integrating clinical assessment with cognitive neuroscience: construct validation of the California Verbal Learning Test","volume":"56","author":"Delis","year":"1988","journal-title":"J Consult Clin Psychol."},{"issue":"2","key":"2023031316284420400_","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1207\/s15324826an0302_8","article-title":"Rey complex figure: memory error patterns and functional abilities","volume":"3","author":"Meyers","year":"1996","journal-title":"Appl Neuropsychol."},{"issue":"4","key":"2023031316284420400_","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1590\/1516-4446-2012-1048","article-title":"Psychometric properties of the Beck depression Inventory-II: a comprehensive review","volume":"35","author":"Wang","year":"2013","journal-title":"Braz J Psychiatry."},{"issue":"6","key":"2023031316284420400_","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1037\/0022-006X.56.6.893","article-title":"An inventory for measuring clinical anxiety: psychometric properties","volume":"56","author":"Beck","year":"1988","journal-title":"J Consult Clin Psychol."},{"issue":"3","key":"2023031316284420400_","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/cbmr.1996.0014","article-title":"AFNI: software for analysis and visualization of functional magnetic resonance neuroimages","volume":"29","author":"Cox","year":"1996","journal-title":"Comput Biomed Res."},{"issue":"4","key":"2023031316284420400_","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.neuroimage.2007.07.004","article-title":"Isolating physiologic noise sources with independently determined spatial measures","volume":"37","author":"Beall","year":"2007","journal-title":"Neuroimage."},{"issue":"2","key":"2023031316284420400_","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jneumeth.2010.01.013","article-title":"Adaptive cyclic physiologic noise modeling and correction in functional MRI","volume":"187","author":"Beall","year":"2010","journal-title":"J Neurosci Methods."},{"issue":"6","key":"2023031316284420400_","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1002\/(SICI)1522-2594(199912)42:6<1014::AID-MRM4>3.0.CO;2-F","article-title":"Real-time 3D image registration for functional MRI","volume":"42","author":"Cox","year":"1999","journal-title":"Magn Reson Med."},{"key":"2023031316284420400_","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neuroimage.2010.04.246","article-title":"Mapping sources of correlation in resting state fMRI, with artifact detection and removal","volume":"52","author":"Jo","year":"2010","journal-title":"Neuroimage"},{"issue":"3","key":"2023031316284420400_","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.neuroimage.2008.09.037","article-title":"A new method for improving functional-to-structural MRI alignment using local Pearson correlation","volume":"44","author":"Saad","year":"2009","journal-title":"Neuroimage."},{"issue":"3","key":"2023031316284420400_","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"J Neurophysiol."},{"issue":"9","key":"2023031316284420400_","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1093\/cercor\/bhx179","article-title":"Local-global parcellation of the human cerebral cortex from intrinsic functional connectivity MRI","volume":"28","author":"Schaefer","year":"2018","journal-title":"Cereb Cortex."},{"issue":"5","key":"2023031316284420400_","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1152\/jn.00339.2011","article-title":"The organization of the human cerebellum estimated by intrinsic functional connectivity","volume":"106","author":"Buckner","year":"2011","journal-title":"J Neurophysiol."},{"issue":"4","key":"2023031316284420400_","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.neuroimage.2010.06.041","article-title":"Network-based statistic: identifying differences in brain 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