{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T05:00:40Z","timestamp":1786770040080,"version":"build-2736575974"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL130702"],"award-info":[{"award-number":["R01HL130702"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD078515"],"award-info":[{"award-number":["R01HD078515"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20 GM103652"],"award-info":[{"award-number":["P20 GM103652"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>To examine the association between maternal sleep disordered breathing (SDB) and glucose metabolism in early gestation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Women with body mass index (BMI) \u226527 kg\/m2 and singleton pregnancies underwent in-home sleep study (HSAT) and homeostatic model assessment (HOMA) in early pregnancy. Insulin resistance (HOMA-IR) and \u03b2-cell function (HOMA %B) were derived. Exclusion criteria included pregestational diabetes, use of continuous positive airway pressure and chronic steroid therapy. We performed linear regression analyses to evaluate the association between continuous measures of SDB (respiratory event index (REI), and oxygen desaturation index (ODI)) and glucose metabolism parameters (HOMA-IR and HOMA %B). Analyses were adjusted for a set of a priori selected variables which included gestational age, maternal age, BMI, ethnicity, race, and parity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>One hundred and ninety-two pregnant women with median (interquartile range) BMI of 35.14 (8.30) kg\/m2 underwent HSAT and HOMA assessment at 11.14 (3) and 15.35 (4.14) gestational weeks, respectively. REI and ODI, as continuous values, were associated with HOMA-IR after adjusting for covariates. OSA (obstructive sleep apnea) diagnosis (REI &amp;gt; 5 events per hour) was not associated with HOMA-IR after adjusting for BMI (p \u2265 0.05). None of the parameters were associated with HOMA %B (p &amp;gt; 0.07).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>SDB and insulin resistance are associated in early pregnancy, with a dose response association between respiratory event index severity and insulin resistance. Further studies are needed to establish if pregnant women with overweight and obesity may benefit from early SDB screening to improve glucose metabolic outcome.<\/jats:p>\n                  <jats:p>Clinical trials: NCT02412696, Positive Airway Pressure, Sleep Apnea, and the Placenta (PAP-SAP) https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02412696?term=Bourjeily&amp;draw=2&amp;rank=2 and NCT02917876, Predictors of De-novo Development of Obstructive Sleep Apnea in Pregnancy (Predictors) https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02917876?term=Bourjeily&amp;draw=2&amp;rank=1<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleep\/zsab281","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T17:34:22Z","timestamp":1641749662000},"source":"Crossref","is-referenced-by-count":23,"title":["Association between sleep disordered breathing in early pregnancy and glucose metabolism"],"prefix":"10.1093","volume":"45","author":[{"given":"Laura","family":"Sanapo","sequence":"first","affiliation":[{"name":"Women\u2019s Medicine Collaborative, The Miriam Hospital , Providence, RI , USA"},{"name":"Department of Medicine, Warren Alpert School of Medicine at Brown University , Providence, RI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret H","family":"Bublitz","sequence":"additional","affiliation":[{"name":"Women\u2019s Medicine Collaborative, The Miriam Hospital , Providence, RI , USA"},{"name":"Department of Medicine, Warren Alpert School of Medicine at Brown University , Providence, RI , USA"},{"name":"Department of Psychiatry and Human Behavior, Warren Alpert School of Medicine at Brown University , Providence, RI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Bai","sequence":"additional","affiliation":[{"name":"Brown University , Providence, RI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niharika","family":"Mehta","sequence":"additional","affiliation":[{"name":"Women\u2019s Medicine Collaborative, The Miriam Hospital , Providence, RI , USA"},{"name":"Department of Medicine, Warren Alpert School of Medicine at Brown University , Providence, RI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geralyn M","family":"Messerlian","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine and Obstetrics and Gynecology, Women and Infants Hospital, Brown University , Providence, RI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-7017","authenticated-orcid":false,"given":"Patrick","family":"Catalano","sequence":"additional","affiliation":[{"name":"Mother Infant Research Institute, Department of Obstetrics and Gynecology, Tufts University School of Medicine, Friedman School of Nutrition Science and Policy , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada","family":"Bourjeily","sequence":"additional","affiliation":[{"name":"Women\u2019s Medicine Collaborative, The Miriam Hospital , Providence, RI , USA"},{"name":"Department of Medicine, Warren Alpert School of Medicine at Brown University , Providence, RI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"issue":"10","key":"2022080801003149200_CIT0001","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1210\/jc.2013-2348","article-title":"Interactions between pregnancy, obstructive sleep apnea, and gestational diabetes mellitus","volume":"98","author":"Reutrakul","year":"2013","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"2022080801003149200_CIT0002","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2337\/dc18-1646","article-title":"Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (HAPO FUS): maternal gestational diabetes mellitus and childhood glucose metabolism","volume":"42","author":"Lowe","year":"2019","journal-title":"Diabetes Care."},{"issue":"9677","key":"2022080801003149200_CIT0003","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0140-6736(09)60731-5","article-title":"Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis","volume":"373","author":"Bellamy","year":"2009","journal-title":"Lancet."},{"issue":"4","key":"2022080801003149200_CIT0004","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S2213-2600(13)70039-0","article-title":"Obstructive sleep apnoea and type 2 diabetes mellitus: a bidirectional association","volume":"1","author":"Aurora","year":"2013","journal-title":"Lancet Respir Med."},{"issue":"Pt 1","key":"2022080801003149200_CIT0005","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1113\/jphysiol.2003.048173","article-title":"Intermittent hypoxia increases insulin resistance in genetically obese mice","volume":"552","author":"Polotsky","year":"2003","journal-title":"J Physiol."},{"issue":"1","key":"2022080801003149200_CIT0006","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1378\/chest.09-0791","article-title":"Effects of sleep fragmentation on glucose metabolism in normal subjects","volume":"137","author":"Stamatakis","year":"2010","journal-title":"Chest."},{"issue":"2","key":"2022080801003149200_CIT0007","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3181\/00379727-207-43809","article-title":"Altered control of ventilation in streptozotocin-induced diabetic rats","volume":"207","author":"Hein","year":"1994","journal-title":"Proc Soc Exp Biol Med."},{"issue":"4","key":"2022080801003149200_CIT0008","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1183\/09031936.00021810","article-title":"Pregnancy and fetal outcomes of symptoms of sleep-disordered breathing","volume":"36","author":"Bourjeily","year":"2010","journal-title":"Eur Respir J."},{"issue":"1","key":"2022080801003149200_CIT0009","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/AOG.0000000000001805","article-title":"Association between sleep-disordered breathing and hypertensive disorders of pregnancy and gestational diabetes mellitus","volume":"129","author":"Facco","year":"2017","journal-title":"Obstet Gynecol."},{"key":"2022080801003149200_CIT0010","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.sleep.2017.06.035","article-title":"Obstructive sleep apnea in pregnancy is associated with adverse maternal outcomes: a national cohort","volume":"38","author":"Bourjeily","year":"2017","journal-title":"Sleep Med."},{"issue":"6","key":"2022080801003149200_CIT0011","doi-asserted-by":"crossref","first-page":"871","DOI":"10.5664\/jcsm.5890","article-title":"Population-based study of sleep apnea in pregnancy and maternal and infant outcomes","volume":"12","author":"Bin","year":"2016","journal-title":"J Clin Sleep Med."},{"issue":"4","key":"2022080801003149200_CIT0012","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1177\/1753495X18780095","article-title":"The role of inflammation in the association between gestational diabetes and obstructive sleep apnea: a pilot study","volume":"11","author":"Bublitz","year":"2018","journal-title":"Obstet Med."},{"issue":"3","key":"2022080801003149200_CIT0013","doi-asserted-by":"crossref","first-page":"327","DOI":"10.5664\/jcsm.6972","article-title":"Continuous positive airway pressure therapy in gestational diabetes with obstructive sleep apnea: a randomized controlled trial","volume":"14","author":"Chirakalwasan","year":"2018","journal-title":"J Clin Sleep Med."},{"issue":"3","key":"2022080801003149200_CIT0014","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s11325-013-0924-2","article-title":"A pilot validation study for the NOX T3(TM) portable monitor for the detection of OSA","volume":"18","author":"Cairns","year":"2014","journal-title":"Sleep Breath."},{"issue":"11","key":"2022080801003149200_CIT0015","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.5664\/jcsm.5176","article-title":"AASM scoring manual version 2.2 updates: new chapters for scoring infant sleep staging and home sleep Apnea testing","volume":"11","author":"Berry","year":"2015","journal-title":"J Clin Sleep Med."},{"issue":"7","key":"2022080801003149200_CIT0016","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia."},{"key":"2022080801003149200_CIT0017","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1475-2840-12-21","article-title":"20\/(fasting C-peptide \u00d7 fasting plasma glucose) is a simple and effective index of insulin resistance in patients with type 2 diabetes mellitus: a preliminary report","volume":"12","author":"Ohkura","year":"2013","journal-title":"Cardiovasc Diabetol."},{"issue":"6","key":"2022080801003149200_CIT0018","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.2337\/diacare.27.6.1487","article-title":"Use and abuse of HOMA modeling","volume":"27","author":"Wallace","year":"2004","journal-title":"Diabetes Care."},{"issue":"3","key":"2022080801003149200_CIT0019","doi-asserted-by":"crossref","first-page":"490","DOI":"10.2337\/dc09-1463","article-title":"Estimates of insulin sensitivity using glucose and C-peptide from the hyperglycemia and adverse pregnancy outcome glucose tolerance test","volume":"33","author":"Radaelli","year":"2010","journal-title":"Diabetes Care."},{"issue":"5","key":"2022080801003149200_CIT0020","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3892\/br.2013.136","article-title":"Evaluation of oral glucose tolerance test, \u03b2-cell function and adverse obstetric outcomes","volume":"1","author":"Zhang","year":"2013","journal-title":"Biomed Rep."},{"issue":"7","key":"2022080801003149200_CIT0021","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1210\/jc.2019-00159","article-title":"Obstructive sleep apnea is associated with altered glycemic patterns in pregnant women with obesity","volume":"104","author":"Farabi","year":"2019","journal-title":"J Clin Endocrinol Metab."},{"issue":"7","key":"2022080801003149200_CIT0022","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1210\/jc.2016-1402","article-title":"Evaluation of circulating determinants of beta-cell function in women with and without gestational diabetes","volume":"101","author":"Retnakaran","year":"2016","journal-title":"J Clin Endocrinol Metab."},{"issue":"12","key":"2022080801003149200_CIT0023","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.2337\/diacare.21.12.2191","article-title":"Correct homeostasis model assessment (HOMA) evaluation uses the computer program","volume":"21","author":"Levy","year":"1998","journal-title":"Diabetes Care."},{"issue":"1","key":"2022080801003149200_CIT0024","doi-asserted-by":"crossref","first-page":"87","DOI":"10.5664\/jcsm.6888","article-title":"Obstructive sleep apnea in gestational diabetes: a pilot study of the role of the hypothalamic-pituitary-adrenal axis","volume":"14","author":"Bublitz","year":"2018","journal-title":"J Clin Sleep Med."},{"issue":"3","key":"2022080801003149200_CIT0025","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/dme.12381","article-title":"Trying to understand gestational diabetes","volume":"31","author":"Catalano","year":"2014","journal-title":"Diabet Med."},{"key":"2022080801003149200_CIT0026","doi-asserted-by":"crossref","first-page":"j1","DOI":"10.1136\/bmj.j1","article-title":"Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child","volume":"356","author":"Catalano","year":"2017","journal-title":"BMJ."},{"issue":"5","key":"2022080801003149200_CIT0027","doi-asserted-by":"crossref","first-page":"586","DOI":"10.2337\/diab.44.5.586","article-title":"Predicting future diabetes in Latino women with gestational diabetes. Utility of early postpartum glucose tolerance testing","volume":"44","author":"Kjos","year":"1995","journal-title":"Diabetes."},{"issue":"5","key":"2022080801003149200_CIT0028","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.2337\/dc06-2517","article-title":"Recurrence of gestational diabetes mellitus: a systematic review","volume":"30","author":"Kim","year":"2007","journal-title":"Diabetes Care."},{"issue":"1","key":"2022080801003149200_CIT0029","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.chest.2020.07.014","article-title":"Maternal sleep-disordered breathing in pregnancy and increased nocturnal glucose levels in women with gestational diabetes mellitus","volume":"159","author":"Newbold","year":"2021","journal-title":"Chest."},{"issue":"5","key":"2022080801003149200_CIT0030","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.sleep.2014.01.004","article-title":"Airflow limitations in pregnant women suspected of sleep-disordered breathing","volume":"15","author":"Bourjeily","year":"2014","journal-title":"Sleep Med."},{"issue":"5","key":"2022080801003149200_CIT0031","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsz022","article-title":"Pulse transit time in pregnancy: a new way to diagnose and classify sleep disordered breathing?","volume":"42","author":"Link","year":"2019","journal-title":"Sleep"},{"key":"2022080801003149200_CIT0032","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1472-6823-13-47","article-title":"Insulin resistance (HOMA-IR) cut-off values and the metabolic syndrome in a general adult population: effect of gender and age: EPIRCE cross-sectional study","volume":"13","author":"Gayoso-Diz","year":"2013","journal-title":"BMC Endocr Disord."},{"key":"2022080801003149200_CIT0033","article-title":"HOMA-IR as a risk factor of gestational diabetes mellitus and a novel simple surrogate index in early pregnancy","author":"Song","year":"2021","journal-title":"Int J Gynaecol Obstet."},{"issue":"5","key":"2022080801003149200_CIT0034","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1152\/japplphysiol.91523.2008","article-title":"Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers","volume":"106","author":"Louis","year":"2009","journal-title":"J Appl Physiol (1985)."},{"issue":"3","key":"2022080801003149200_CIT0035","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1164\/rccm.200809-1392OC","article-title":"Alterations in glucose disposal in sleep-disordered breathing","volume":"179","author":"Punjabi","year":"2009","journal-title":"Am J Respir Crit Care Med."},{"issue":"4","key":"2022080801003149200_CIT0036","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.amjhyper.2006.10.009","article-title":"Determination of insulin resistance using the homeostatic model assessment (HOMA) and its relation with the risk of developing pregnancy-induced hypertension","volume":"20","author":"Sierra-Laguado","year":"2007","journal-title":"Am J Hypertens."},{"key":"2022080801003149200_CIT0037","doi-asserted-by":"crossref","first-page":"140851","DOI":"10.1155\/2014\/140851","article-title":"Estimating rate of insulin resistance in patients with preeclampsia using HOMA-IR index and comparison with nonpreeclampsia pregnant women","volume":"2014","author":"Abhari","year":"2014","journal-title":"Biomed Res Int."},{"issue":"4","key":"2022080801003149200_CIT0038","doi-asserted-by":"crossref","first-page":"845","DOI":"10.2337\/dc12-0840","article-title":"Limitations in the use of indices using glucose and insulin levels to predict insulin sensitivity: impact of race and gender and superiority of the indices derived from oral glucose tolerance test in African Americans","volume":"36","author":"Pisprasert","year":"2013","journal-title":"Diabetes Care."},{"issue":"8","key":"2022080801003149200_CIT0039","first-page":"CR480","article-title":"Comparison of simple indices of insulin sensitivity using the euglycemic hyperinsulinemic clamp technique","volume":"10","author":"Straczkowski","year":"2004","journal-title":"Med Sci Monit."},{"issue":"3","key":"2022080801003149200_CIT0040","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1053\/sper.2002.33977","article-title":"Clinical utility and approaches for estimating insulin sensitivity in pregnancy","volume":"26","author":"Catalano","year":"2002","journal-title":"Semin Perinatol."},{"issue":"8","key":"2022080801003149200_CIT0041","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s00125-019-4881-6","article-title":"Augmented insulin secretory response in early pregnancy","volume":"62","author":"Powe","year":"2019","journal-title":"Diabetologia."},{"issue":"5","key":"2022080801003149200_CIT0042","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.2337\/diacare.28.5.1207","article-title":"Early pregnancy insulin resistance and subsequent gestational diabetes mellitus","volume":"28","author":"Smirnakis","year":"2005","journal-title":"Diabetes Care."},{"issue":"12","key":"2022080801003149200_CIT0043","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.2337\/dc14-1529","article-title":"Each degree of glucose intolerance in pregnancy predicts distinct trajectories of \u03b2-cell function, insulin sensitivity, and glycemia in the first 3 years postpartum","volume":"37","author":"Kramer","year":"2014","journal-title":"Diabetes Care."},{"issue":"10","key":"2022080801003149200_CIT0044","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1513\/AnnalsATS.201907-507ED","article-title":"The challenge of screening for obstructive sleep apnea in pregnancy","volume":"16","author":"Malham\u00e9","year":"2019","journal-title":"Ann Am Thorac Soc."},{"issue":"6","key":"2022080801003149200_CIT0045","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.2337\/dc15-2672","article-title":"Heterogeneous contribution of insulin sensitivity and secretion defects to gestational diabetes mellitus","volume":"39","author":"Powe","year":"2016","journal-title":"Diabetes Care."},{"key":"2022080801003149200_CIT0046","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.sleep.2021.02.043","article-title":"Objectively assessed sleep-disordered breathing during pregnancy and infant birthweight","volume":"81","author":"Hawkins","year":"2021","journal-title":"Sleep Med."},{"issue":"1","key":"2022080801003149200_CIT0047","doi-asserted-by":"crossref","first-page":"10768","DOI":"10.1038\/s41598-018-29052-y","article-title":"Mild maternal obstructive sleep apnea in non-obese pregnant women and accelerated fetal growth","volume":"8","author":"Telerant","year":"2018","journal-title":"Sci Rep."},{"issue":"6","key":"2022080801003149200_CIT0048","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.amepre.2015.11.012","article-title":"Risk factors for childhood obesity in the first 1,000 days: a systematic review","volume":"50","author":"Woo Baidal","year":"2016","journal-title":"Am J Prev Med."},{"issue":"3","key":"2022080801003149200_CIT0049","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0029-7844(96)00517-0","article-title":"Longitudinal changes in the relationship between body mass index and percent body fat in pregnancy","volume":"89","author":"Lindsay","year":"1997","journal-title":"Obstet Gynecol."},{"issue":"2","key":"2022080801003149200_CIT0050","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/AOG.0000000000002498","article-title":"ACOG Practice bulletin no. 190 summary: gestational diabetes mellitus","volume":"131","year":"2018","journal-title":"Obstet Gynecol."}],"container-title":["Sleep"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/sleep\/advance-article-pdf\/doi\/10.1093\/sleep\/zsab281\/42005513\/zsab281.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/sleep\/article-pdf\/45\/4\/zsab281\/45286955\/zsab281.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/sleep\/article-pdf\/45\/4\/zsab281\/45286955\/zsab281.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T01:01:08Z","timestamp":1659920468000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/sleep\/article\/doi\/10.1093\/sleep\/zsab281\/6491400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,6]]},"references-count":50,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,1,6]]},"published-print":{"date-parts":[[2022,4,11]]}},"URL":"https:\/\/doi.org\/10.1093\/sleep\/zsab281","relation":{},"ISSN":["0161-8105","1550-9109"],"issn-type":[{"value":"0161-8105","type":"print"},{"value":"1550-9109","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,4,1]]},"published":{"date-parts":[[2022,1,6]]},"article-number":"zsab281"}}