{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:26:39Z","timestamp":1790666799330,"version":"4.1.0"},"reference-count":131,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL128970"],"award-info":[{"award-number":["R01 HL128970"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL133100"],"award-info":[{"award-number":["R01 HL133100"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL13892"],"award-info":[{"award-number":["R01 HL13892"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R61 HL156240"],"award-info":[{"award-number":["R61 HL156240"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Obesity hypoventilation syndrome (OHS) is defined as daytime hypercapnia in obese individuals in the absence of other underlying causes. In the United States, OHS is present in 10%\u201320% of obese patients with obstructive sleep apnea and is linked to hypoventilation during sleep. OHS leads to high cardiorespiratory morbidity and mortality, and there is no effective pharmacotherapy. The depressed hypercapnic ventilatory response plays a key role in OHS. The pathogenesis of OHS has been linked to resistance to an adipocyte-produced hormone, leptin, a major regulator of metabolism and control of breathing. Mechanisms by which leptin modulates the control of breathing are potential targets for novel therapeutic strategies in OHS. Recent advances shed light on the molecular pathways related to the central chemoreceptor function in health and disease. Leptin signaling in the nucleus of the solitary tract, retrotrapezoid nucleus, hypoglossal nucleus, and dorsomedial hypothalamus, and anatomical projections from these nuclei to the respiratory control centers, may contribute to OHS. In this review, we describe current views on leptin-mediated mechanisms that regulate breathing and CO2 homeostasis with a focus on potential therapeutics for the treatment of OHS.<\/jats:p>","DOI":"10.1093\/sleep\/zsac153","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T03:06:24Z","timestamp":1656731184000},"source":"Crossref","is-referenced-by-count":44,"title":["Leptin-mediated neural targets in obesity hypoventilation syndrome"],"prefix":"10.1093","volume":"45","author":[{"given":"Mateus R","family":"Amorim","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Aung","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8135-5433","authenticated-orcid":false,"given":"Babak","family":"Mokhlesi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Rush University Medical Center , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vsevolod Y","family":"Polotsky","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"issue":"6","key":"2022090808585008100_CIT0001","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1177\/0884533609351532","article-title":"Sleep disordered breathing and obesity: pathophysiology, complications and treatment","volume":"24","author":"Leinum","year":"2009","journal-title":"Nutr Clin Pract."},{"issue":"17","key":"2022090808585008100_CIT0002","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1056\/NEJM199304293281704","article-title":"The occurrence of sleep-disordered breathing among middle-aged adults","volume":"328","author":"Young","year":"1993","journal-title":"N Engl J Med."},{"issue":"0021-972X","key":"2022090808585008100_CIT0003","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1210\/jcem.85.3.6484","article-title":"Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia [see comments]","volume":"85","author":"Vgontzas","year":"2000","journal-title":"J Clin Endocrinol Metab."},{"issue":"5","key":"2022090808585008100_CIT0004","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.sleep.2009.10.005","article-title":"Obstructive sleep apnea syndrome in the Sao Paulo Epidemiologic Sleep Study","volume":"11","author":"Tufik","year":"2010","journal-title":"Sleep Med."},{"issue":"9","key":"2022090808585008100_CIT0005","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/aje\/kws342","article-title":"Increased prevalence of sleep-disordered breathing in adults","volume":"177","author":"Peppard","year":"2013","journal-title":"Am J Epidemiol."},{"issue":"4","key":"2022090808585008100_CIT0006","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S2213-2600(15)00043-0","article-title":"Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study","volume":"3","author":"Heinzer","year":"2015","journal-title":"Lancet Respir Med."},{"issue":"6","key":"2022090808585008100_CIT0007","first-page":"568","article-title":"Polygraphic study of diurnal and nocturnal (hypnic and respiratory) episodal manifestations of Pickwick syndrome","volume":"112","author":"Gastaut","year":"1965","journal-title":"Rev Neurol (Paris)."},{"issue":"1","key":"2022090808585008100_CIT0008","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/sbr.12078","article-title":"Metabolic dysfunction in obstructive sleep apnea: a critical examination of underlying mechanisms","volume":"13","author":"Mesarwi","year":"2015","journal-title":"Sleep Biol Rhythms."},{"issue":"8","key":"2022090808585008100_CIT0009","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S2213-2600(19)30198-5","article-title":"Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis","volume":"7","author":"Benjafield","year":"2019","journal-title":"Lancet Respir Med."},{"issue":"5","key":"2022090808585008100_CIT0010","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1164\/ajrccm.165.5.2104087","article-title":"Sleep-disordered breathing and insulin resistance in middle-aged and overweight men","volume":"165","author":"Punjabi","year":"2002","journal-title":"Am J Respir Crit Care Med."},{"issue":"9","key":"2022090808585008100_CIT0011","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1164\/rccm.2109080","article-title":"Epidemiology of obstructive sleep apnea: a population health perspective","volume":"165","author":"Young","year":"2002","journal-title":"Am J Respir Crit Care Med."},{"issue":"2","key":"2022090808585008100_CIT0012","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1513\/pats.200708-122MG","article-title":"Assessment and management of patients with obesity hypoventilation syndrome","volume":"5","author":"Mokhlesi","year":"2008","journal-title":"Proc Am Thorac Soc."},{"issue":"3","key":"2022090808585008100_CIT0013","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jsmc.2014.05.007","article-title":"Obesity hypoventilation syndrome epidemiology and diagnosis","volume":"9","author":"Balachandran","year":"2014","journal-title":"Sleep Med Clin."},{"issue":"23","key":"2022090808585008100_CIT0014","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1001\/jama.2018.7270","article-title":"Differences in obesity prevalence by demographic characteristics and urbanization level among adults in the United States, 2013-2016","volume":"319","author":"Hales","year":"2018","journal-title":"JAMA."},{"issue":"151","key":"2022090808585008100_CIT0015","doi-asserted-by":"crossref","first-page":"180097","DOI":"10.1183\/16000617.0097-2018","article-title":"Obesity hypoventilation syndrome","volume":"28","author":"Masa","year":"2019","journal-title":"Eur Respir Rev."},{"issue":"10182","key":"2022090808585008100_CIT0016","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/S0140-6736(18)32978-7","article-title":"Long-term clinical effectiveness of continuous positive airway pressure therapy versus non-invasive ventilation therapy in patients with obesity hypoventilation syndrome: a multicentre, open-label, randomised controlled trial","volume":"393","author":"Masa","year":"2019","journal-title":"Lancet."},{"issue":"3","key":"2022090808585008100_CIT0017","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1164\/rccm.201905-1071ST","article-title":"Evaluation and management of obesity hypoventilation syndrome. An official american thoracic society clinical practice guideline","volume":"200","author":"Mokhlesi","year":"2019","journal-title":"Am J Respir Crit Care Med."},{"issue":"1","key":"2022090808585008100_CIT0018","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jsmc.2020.10.009","article-title":"Adherence to positive airway pressure therapy in obesity hypoventilation syndrome","volume":"16","author":"Wearn","year":"2021","journal-title":"Sleep Med Clin."},{"issue":"10","key":"2022090808585008100_CIT0019","first-page":"1347","article-title":"Obesity hypoventilation syndrome: a state-of-the-art review","volume":"55","author":"Mokhlesi","year":"2010","journal-title":"Respir Care."},{"issue":"12","key":"2022090808585008100_CIT0020","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1164\/rccm.201206-1101OC","article-title":"Noninvasive ventilation in acute hypercapnic respiratory failure caused by obesity hypoventilation syndrome and chronic obstructive pulmonary disease","volume":"186","author":"Carrillo","year":"2012","journal-title":"Am J Respir Crit Care Med."},{"issue":"1","key":"2022090808585008100_CIT0021","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/osp4.27","article-title":"The clinical characteristics and hospital and post-hospital survival of patients with the obesity hypoventilation syndrome: analysis of a large cohort","volume":"2","author":"Marik","year":"2016","journal-title":"Obes Sci Pract."},{"issue":"1","key":"2022090808585008100_CIT0022","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/apha.12257","article-title":"Leptin into the ventrolateral medulla facilitates chemorespiratory response in leptin-deficient (ob\/ob) mice","volume":"211","author":"Bassi","year":"2014","journal-title":"Acta Physiol (Oxf)."},{"issue":"1","key":"2022090808585008100_CIT0023","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1152\/japplphysiol.00494.2015","article-title":"The effect of leptin replacement on sleep-disordered breathing in the leptin-deficient ob\/ob mouse","volume":"120","author":"Pho","year":"2016","journal-title":"J Appl Physiol (1985)."},{"issue":"5","key":"2022090808585008100_CIT0024","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.5665\/sleep.5762","article-title":"Localizing effects of leptin on upper airway and respiratory control during sleep","volume":"39","author":"Yao","year":"2016","journal-title":"Sleep."},{"issue":"8","key":"2022090808585008100_CIT0025","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsy089","article-title":"Sleep-disordered breathing in C57BL\/6J mice with diet-induced obesity","volume":"41","author":"Fleury Curado","year":"2018","journal-title":"Sleep."},{"issue":"5 Pt 1","key":"2022090808585008100_CIT0026","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1164\/ajrccm.159.5.9809025","article-title":"Leptin prevents respiratory depression in obesity","volume":"159","author":"O\u2019donnell","year":"1999","journal-title":"Am J Respir Crit Care Med."},{"issue":"11","key":"2022090808585008100_CIT0027","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1513\/AnnalsATS.201702-181FR","article-title":"Role of leptin in obstructive sleep apnea","volume":"14","author":"Imayama","year":"2017","journal-title":"Ann Am Thorac Soc."},{"issue":"6","key":"2022090808585008100_CIT0028","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1113\/JP270308","article-title":"Facilitation of breathing by leptin effects in the central nervous system","volume":"594","author":"Bassi","year":"2016","journal-title":"J Physiol."},{"issue":"1","key":"2022090808585008100_CIT0029","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/thorax.57.1.75","article-title":"Association of serum leptin with hypoventilation in human obesity","volume":"57","author":"Phipps","year":"2002","journal-title":"Thorax."},{"issue":"6","key":"2022090808585008100_CIT0030","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41583-018-0003-6","article-title":"Breathing matters","volume":"19","author":"Del Negro","year":"2018","journal-title":"Nat Rev Neurosci."},{"issue":"6505","key":"2022090808585008100_CIT0031","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional cloning of the mouse obese gene and its human homologue","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature."},{"issue":"3","key":"2022090808585008100_CIT0032","doi-asserted-by":"crossref","first-page":"973S","DOI":"10.3945\/ajcn.2008.26788B","article-title":"Leptin at 14 y of age: an ongoing story","volume":"89","author":"Friedman","year":"2009","journal-title":"Am J Clin Nutr."},{"issue":"5223","key":"2022090808585008100_CIT0033","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1126\/science.7624777","article-title":"Weight-reducing effects of the plasma protein encoded by the obese gene","volume":"269","author":"Halaas","year":"1995","journal-title":"Science."},{"issue":"4","key":"2022090808585008100_CIT0034","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0092-8674(01)00240-9","article-title":"Obesity and the regulation of energy balance","volume":"104","author":"Spiegelman","year":"2001","journal-title":"Cell."},{"issue":"6","key":"2022090808585008100_CIT0035","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsab046","article-title":"Leptin receptor expression in the dorsomedial hypothalamus stimulates breathing during NREM sleep in db\/db mice","volume":"44","author":"Pho","year":"2021","journal-title":"Sleep."},{"issue":"2","key":"2022090808585008100_CIT0036","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1152\/jappl.1996.81.2.716","article-title":"Modified control of breathing in genetically obese (ob\/ob) mice","volume":"81","author":"Tankersley","year":"1996","journal-title":"J Appl Physiol (1985)."},{"issue":"12","key":"2022090808585008100_CIT0037","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1056\/NEJM199909163411204","article-title":"Effects of recombinant leptin therapy in a child with congenital leptin deficiency","volume":"341","author":"Farooqi","year":"1999","journal-title":"N Engl J Med."},{"issue":"2 Pt 2","key":"2022090808585008100_CIT0038","first-page":"s38","article-title":"Leptin, leptin receptors, and the control of body weight","volume":"56","author":"Friedman","year":"1998","journal-title":"Nutr Rev."},{"key":"2022090808585008100_CIT0039","doi-asserted-by":"crossref","first-page":"648239","DOI":"10.1155\/2015\/648239","article-title":"Differential effects of leptin and adiponectin in endothelial angiogenesis. Finucane FM, ed","volume":"2015","author":"Adya","year":"2015","journal-title":"J Diabetes Res."},{"issue":"3","key":"2022090808585008100_CIT0040","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11055-009-9124-8","article-title":"Respiratory responses to microinjections of leptin into the solitary tract nucleus","volume":"39","author":"Inyushkin","year":"2009","journal-title":"Neurosci Behav Physiol."},{"issue":"7","key":"2022090808585008100_CIT0041","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s11055-010-9316-2","article-title":"Mechanisms of the respiratory activity of leptin at the level of the solitary tract nucleus","volume":"40","author":"Inyushkina","year":"2010","journal-title":"Neurosci Behav Physiol."},{"issue":"1","key":"2022090808585008100_CIT0042","doi-asserted-by":"crossref","first-page":"T63","DOI":"10.1530\/JOE-14-0480","article-title":"20 years of leptin: human disorders of leptin action","volume":"223","author":"Farooqi","year":"2014","journal-title":"J Endocrinol."},{"issue":"5","key":"2022090808585008100_CIT0043","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nn1226","article-title":"Orexigen-sensitive NPY\/AgRP pacemaker neurons in the hypothalamic arcuate nucleus","volume":"7","author":"van den Top","year":"2004","journal-title":"Nat Neurosci."},{"issue":"30","key":"2022090808585008100_CIT0044","doi-asserted-by":"crossref","first-page":"10022","DOI":"10.1523\/JNEUROSCI.2868-13.2014","article-title":"Leptin-induced spine formation requires TrpC channels and the CaM Kinase cascade in the hippocampus","volume":"34","author":"Dhar","year":"2014","journal-title":"J Neurosci."},{"issue":"11","key":"2022090808585008100_CIT0045","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/nm1195-1155","article-title":"Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects","volume":"1","author":"Maffei","year":"1995","journal-title":"Nat Med."},{"issue":"5","key":"2022090808585008100_CIT0046","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1056\/NEJM199602013340503","article-title":"Serum immunoreactive-leptin concentrations in normal-weight and obese humans","volume":"334","author":"Considine","year":"1996","journal-title":"N Engl J Med."},{"issue":"6","key":"2022090808585008100_CIT0047","doi-asserted-by":"crossref","first-page":"108358","DOI":"10.1016\/j.celrep.2020.108358","article-title":"A leptin-mediated neural mechanism linking breathing to metabolism","volume":"33","author":"Do","year":"2020","journal-title":"Cell Rep."},{"issue":"5","key":"2022090808585008100_CIT0048","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nm0596-589","article-title":"Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans","volume":"2","author":"Schwartz","year":"1996","journal-title":"Nat Med."},{"issue":"11","key":"2022090808585008100_CIT0049","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/S0196-9781(99)00139-4","article-title":"Impaired transport of leptin across the blood-brain barrier in obesity","volume":"20","author":"Banks","year":"1999","journal-title":"Peptides."},{"key":"2022090808585008100_CIT0050","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.2741\/3885","article-title":"Leptin receptor signaling: pathways to leptin resistance","volume":"16","author":"Wauman","year":"2011","journal-title":"Front Biosci (Landmark Ed)."},{"key":"2022090808585008100_CIT0051","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.physbeh.2014.04.003","article-title":"Advances in understanding the interrelations between leptin resistance and obesity","volume":"130","author":"Pan","year":"2014","journal-title":"Physiol Behav."},{"issue":"2","key":"2022090808585008100_CIT0052","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s11684-013-0263-5","article-title":"Leptin signaling and leptin resistance","volume":"7","author":"Zhou","year":"2013","journal-title":"Front Med."},{"issue":"1-2","key":"2022090808585008100_CIT0053","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0303-7207(02)00178-8","article-title":"Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line","volume":"195","author":"Kaszubska","year":"2002","journal-title":"Mol Cell Endocrinol."},{"issue":"51","key":"2022090808585008100_CIT0054","doi-asserted-by":"crossref","first-page":"40649","DOI":"10.1074\/jbc.M007577200","article-title":"SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985","volume":"275","author":"Bjorbak","year":"2000","journal-title":"J Biol Chem."},{"issue":"6","key":"2022090808585008100_CIT0055","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1164\/rccm.201805-0879OC","article-title":"Intranasal leptin relieves sleep-disordered breathing in mice with diet-induced obesity","volume":"199","author":"Berger","year":"2019","journal-title":"Am J Respir Crit Care Med."},{"issue":"1","key":"2022090808585008100_CIT0056","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s12967-021-02803-8","article-title":"Intranasal leptin improves survival after opioid overdose in a mouse model","volume":"19","author":"Freire","year":"2021","journal-title":"J Transl Med."},{"issue":"5223","key":"2022090808585008100_CIT0057","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1126\/science.7624776","article-title":"Effects of the obese gene product on body weight regulation in ob\/ob mice","volume":"269","author":"Pelleymounter","year":"1995","journal-title":"Science."},{"issue":"25","key":"2022090808585008100_CIT0058","doi-asserted-by":"crossref","first-page":"14804","DOI":"10.1073\/pnas.93.25.14804","article-title":"Woo SLC. Correction of obesity and diabetes in genetically obese mice by leptin gene therapy","volume":"93","author":"Muzzin","year":"1996","journal-title":"Proc Natl Acad Sci USA."},{"issue":"1","key":"2022090808585008100_CIT0059","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1210\/endo.139.1.5675","article-title":"A leptin dose-response study in obese (ob\/ob) and lean (+\/?) mice","volume":"139","author":"Harris","year":"1998","journal-title":"Endocrinology."},{"issue":"2","key":"2022090808585008100_CIT0060","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00424-012-1111-1","article-title":"Central leptin replacement enhances chemorespiratory responses in leptin-deficient mice independent of changes in body weight","volume":"464","author":"Bassi","year":"2012","journal-title":"Pflugers Arch."},{"issue":"3","key":"2022090808585008100_CIT0061","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0092-8674(00)81294-5","article-title":"Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db\/db mice","volume":"84","author":"Chen","year":"1996","journal-title":"Cell."},{"issue":"6566","key":"2022090808585008100_CIT0062","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/379632a0","article-title":"Abnormal splicing of the leptin receptor in diabetic mice","volume":"379","author":"Lee","year":"1996","journal-title":"Nature."},{"issue":"5223","key":"2022090808585008100_CIT0063","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1126\/science.7624778","article-title":"Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks","volume":"269","author":"Campfield","year":"1995","journal-title":"Science."},{"issue":"8","key":"2022090808585008100_CIT0064","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1096\/fasebj.8.8.8181666","article-title":"Obesity, diabetes, and neoplasia in yellow A(vy)\/- mice: ectopic expression of the agouti gene","volume":"8","author":"Yen","year":"1994","journal-title":"FASEB J."},{"issue":"6658","key":"2022090808585008100_CIT0065","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/37016","article-title":"Melanocortin receptors in leptin effects","volume":"390","author":"Seeley","year":"1997","journal-title":"Nature."},{"issue":"2 Pt 2","key":"2022090808585008100_CIT0066","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1161\/hy0202.102836","article-title":"Selective resistance to central neural administration of leptin in agouti obese mice","volume":"39","author":"Rahmouni","year":"2002","journal-title":"Hypertension."},{"issue":"10","key":"2022090808585008100_CIT0067","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.2337\/diabetes.48.10.2028","article-title":"Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action","volume":"48","author":"Ebihara","year":"1999","journal-title":"Diabetes."},{"issue":"3","key":"2022090808585008100_CIT0068","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1152\/japplphysiol.00926.2003","article-title":"Impact of interrupted leptin pathways on ventilatory control","volume":"96","author":"Polotsky","year":"2004","journal-title":"J Appl Physiol (1985)."},{"issue":"3","key":"2022090808585008100_CIT0069","first-page":"834","article-title":"Origin of inbred NZ mouse strains","volume":"30","author":"Bielschowsky","year":"1970","journal-title":"Cancer Res."},{"key":"2022090808585008100_CIT0070","doi-asserted-by":"crossref","first-page":"732","DOI":"10.3389\/fendo.2018.00732","article-title":"Sex differences in cardiac mitochondria in the New Zealand obese mouse","volume":"9","author":"John","year":"2018","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"10","key":"2022090808585008100_CIT0071","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.1210\/endo.138.10.5428","article-title":"Hyperleptinemia, leptin resistance, and polymorphic leptin receptor in the New Zealand obese mouse","volume":"138","author":"Igel","year":"1997","journal-title":"Endocrinology."},{"issue":"3-4","key":"2022090808585008100_CIT0072","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s12263-008-0103-4","article-title":"Impaired leptin activity in New Zealand Obese mice: model of angiogenesis","volume":"3","author":"Wator","year":"2008","journal-title":"Genes Nutr."},{"issue":"2","key":"2022090808585008100_CIT0073","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1164\/rccm.200809-1435OC","article-title":"Altered upper airway and soft tissue structures in the New Zealand Obese mouse","volume":"179","author":"Brennick","year":"2009","journal-title":"Am J Respir Crit Care Med."},{"issue":"4","key":"2022090808585008100_CIT0074","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1152\/japplphysiol.00818.2011","article-title":"Novel whole body plethysmography system for the continuous characterization of sleep and breathing in a mouse","volume":"112","author":"Hernandez","year":"2012","journal-title":"J Appl Physiol (1985)."},{"issue":"10","key":"2022090808585008100_CIT0075","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1164\/rccm.201801-0162LE","article-title":"New Zealand obese mice as a translational model of obesity-related obstructive sleep apnea syndrome","volume":"198","author":"Baum","year":"2018","journal-title":"Am J Respir Crit Care Med."},{"key":"2022090808585008100_CIT0076","doi-asserted-by":"crossref","first-page":"688375","DOI":"10.3389\/fphys.2021.688375","article-title":"Leptin receptor blockade attenuates hypertension, but does not affect ventilatory response to hypoxia in a model of polygenic obesity","volume":"12","author":"Kim","year":"2021","journal-title":"Front Physiol."},{"issue":"3","key":"2022090808585008100_CIT0077","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1172\/JCI119171","article-title":"Diet-induced obese mice develop peripheral, but not central, resistance to leptin","volume":"99","author":"Van Heek","year":"1997","journal-title":"J Clin Invest."},{"issue":"1","key":"2022090808585008100_CIT0078","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1172\/JCI119125","article-title":"Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels","volume":"99","author":"Golden","year":"1997","journal-title":"J Clin Invest."},{"issue":"6","key":"2022090808585008100_CIT0079","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/JLB.3AB0820-092RR","article-title":"Peripheral leptin signaling persists in innate immune cells during diet-induced obesity","volume":"109","author":"Souza-Almeida","year":"2021","journal-title":"J Leukoc Biol."},{"issue":"1","key":"2022090808585008100_CIT0080","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/ng0596-18","article-title":"Leptin receptor missense mutation in the fatty Zucker rat","volume":"13","author":"Phillips","year":"1996","journal-title":"Nat Genet."},{"issue":"6","key":"2022090808585008100_CIT0081","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0361-9230(85)90113-3","article-title":"Patterns of hyperphagia in the Zucker obese rat: a role for fat cell size and number?","volume":"14","author":"Vasselli","year":"1985","journal-title":"Brain Res Bull."},{"issue":"12","key":"2022090808585008100_CIT0082","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1055\/s-2007-979874","article-title":"Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats","volume":"28","author":"Seeley","year":"1996","journal-title":"Horm Metab Res."},{"issue":"2","key":"2022090808585008100_CIT0083","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0031-9384(98)00173-5","article-title":"Responses of lean and obese Zucker rats to centrally administered leptin","volume":"65","author":"Wang","year":"1998","journal-title":"Physiol Behav."},{"issue":"2","key":"2022090808585008100_CIT0084","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1164\/ajrccm.150.2.8049815","article-title":"Pulmonary ventilation and mechanics in morbidly obese Zucker rats","volume":"150","author":"Farkas","year":"1994","journal-title":"Am J Respir Crit Care Med."},{"key":"2022090808585008100_CIT0085","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3389\/fphys.2018.00249","article-title":"Leptin signaling in the carotid body regulates a hypoxic ventilatory response through altering TASK channel expression","volume":"9","author":"Yuan","year":"2018","journal-title":"Front Physiol."},{"issue":"6","key":"2022090808585008100_CIT0086","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1463-1326.2006.00653.x","article-title":"Modulation of central leptin sensitivity and energy balance in a rat model of diet-induced obesity","volume":"9","author":"Fam","year":"2007","journal-title":"Diabetes Obes Metab."},{"key":"2022090808585008100_CIT0087","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/5137947","article-title":"Leptin and leptin resistance in the pathogenesis of obstructive sleep apnea: a possible link to oxidative stress and cardiovascular complications","volume":"2018","author":"Berger","year":"2018","journal-title":"Oxid Med Cell Longevity."},{"issue":"3","key":"2022090808585008100_CIT0088","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1164\/rccm.201008-1280CI","article-title":"Obesity hypoventilation syndrome: mechanisms and management","volume":"183","author":"Piper","year":"2011","journal-title":"Am J Respir Crit Care Med."},{"issue":"12","key":"2022090808585008100_CIT0089","first-page":"1723","article-title":"The obesity hypoventilation syndrome","volume":"53","author":"Powers","year":"2008","journal-title":"Respir Care."},{"issue":"9","key":"2022090808585008100_CIT0090","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.amjmed.2005.03.042","article-title":"The obesity hypoventilation syndrome","volume":"118","author":"Olson","year":"2005","journal-title":"Am J Med."},{"issue":"1","key":"2022090808585008100_CIT0091","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0002-9343(83)91171-3","article-title":"Neuromechanical properties in obese patients during carbon dioxide rebreathing","volume":"75","author":"Sampson","year":"1983","journal-title":"Am J Med."},{"issue":"3","key":"2022090808585008100_CIT0092","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1002\/cphy.c190031","article-title":"Leptin: master regulator of biological functions that affects breathing","volume":"10","author":"Gauda","year":"2020","journal-title":"Compr Physiol."},{"issue":"6","key":"2022090808585008100_CIT0093","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1152\/jn.00985.2007","article-title":"Paton JFR. Spatial and functional architecture of the mammalian brain stem respiratory network: a hierarchy of three oscillatory mechanisms","volume":"98","author":"Smith","year":"2007","journal-title":"J Neurophysiol."},{"issue":"2 Pt 2","key":"2022090808585008100_CIT0094","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1164\/arrd.1984.129.2P2.S31","article-title":"Exercise and chemoreception","volume":"129","author":"Dempsey","year":"1984","journal-title":"Am Rev Respir Dis."},{"issue":"11","key":"2022090808585008100_CIT0095","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.tins.2019.09.002","article-title":"The retrotrapezoid nucleus: central chemoreceptor and regulator of breathing automaticity","volume":"42","author":"Guyenet","year":"2019","journal-title":"Trends Neurosci."},{"issue":"2","key":"2022090808585008100_CIT0096","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1152\/physrev.1994.74.2.323","article-title":"Functional organization of central pathways regulating the cardiovascular system","volume":"74","author":"Dampney","year":"1994","journal-title":"Physiol Rev."},{"key":"2022090808585008100_CIT0097","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2014.00238","article-title":"Colombari DSA, Colombari E. The nucleus of the solitary tract and the coordination of respiratory and sympathetic activities","volume":"5","author":"Zoccal","year":"2014","journal-title":"Front Physiol."},{"issue":"1","key":"2022090808585008100_CIT0098","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1210\/endo.139.1.5685","article-title":"Localization of leptin receptor (Ob-R) messenger ribonucleic acid in the rodent hindbrain","volume":"139","author":"Mercer","year":"1998","journal-title":"Endocrinology."},{"issue":"5","key":"2022090808585008100_CIT0099","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/cne.22025","article-title":"Leptin targets in the mouse brain","volume":"514","author":"Scott","year":"2009","journal-title":"J Comp Neurol."},{"issue":"2","key":"2022090808585008100_CIT0100","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12264-021-00742-4","article-title":"A neural circuit mechanism controlling breathing by leptin in the nucleus tractus solitarii","volume":"38","author":"Yu","year":"2022","journal-title":"Neurosci Bull."},{"issue":"13","key":"2022090808585008100_CIT0101","doi-asserted-by":"crossref","first-page":"6742","DOI":"10.3390\/ijms22136742","article-title":"The effect of DREADD activation of leptin receptor positive neurons in the nucleus of the solitary tract on sleep disordered breathing","volume":"22","author":"Amorim","year":"2021","journal-title":"Int J Mol Sci ."},{"issue":"15","key":"2022090808585008100_CIT0102","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1113\/JP275362","article-title":"High fat diet blunts the effects of leptin on ventilation and on carotid body activity","volume":"596","author":"Ribeiro","year":"2018","journal-title":"J Physiol."},{"issue":"1","key":"2022090808585008100_CIT0103","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1113\/JP276900","article-title":"Leptin acts in the carotid bodies to increase minute ventilation during wakefulness and sleep and augment the hypoxic ventilatory response","volume":"597","author":"Caballero-Eraso","year":"2019","journal-title":"J Physiol."},{"issue":"12","key":"2022090808585008100_CIT0104","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1152\/japplphysiol.00164.2015","article-title":"Selective optogenetic stimulation of the retrotrapezoid nucleus in sleeping rats activates breathing without changing blood pressure or causing arousal or sighs","volume":"118","author":"Burke","year":"2015","journal-title":"J Appl Physiol (1985)."},{"key":"2022090808585008100_CIT0105","doi-asserted-by":"crossref","first-page":"117994","DOI":"10.1016\/j.lfs.2020.117994","article-title":"Disordered Leptin signaling in the retrotrapezoid nucleus is associated with the impaired hypercapnic ventilatory response in obesity","volume":"257","author":"Wei","year":"2020","journal-title":"Life Sci."},{"issue":"12","key":"2022090808585008100_CIT0106","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1056\/NEJMoa022050","article-title":"Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene","volume":"348","author":"Farooqi","year":"2003","journal-title":"N Engl J Med."},{"key":"2022090808585008100_CIT0107","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/B978-0-12-417197-8.00005-5","article-title":"Constitutive activity in melanocortin-4 receptor: biased signaling of inverse agonists","volume":"70","author":"Tao","year":"2014","journal-title":"Adv Pharmacol."},{"issue":"2","key":"2022090808585008100_CIT0108","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2337\/diabetes.49.2.177","article-title":"Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone","volume":"49","author":"Kim","year":"2000","journal-title":"Diabetes."},{"issue":"6","key":"2022090808585008100_CIT0109","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1055\/s-0028-1102942","article-title":"Mutations in the melanocortin 4 receptor (MC4R) gene in obese patients in Norway","volume":"117","author":"Wangensteen","year":"2009","journal-title":"Exp Clin Endocrinol Diabetes."},{"issue":"1","key":"2022090808585008100_CIT0110","doi-asserted-by":"crossref","first-page":"99","DOI":"10.5664\/jcsm.3374","article-title":"Severe obstructive sleep apnea in a child with melanocortin-4 receptor deficiency","volume":"10","author":"Pillai","year":"2014","journal-title":"J Clin Sleep Med."},{"issue":"10","key":"2022090808585008100_CIT0111","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.molmet.2017.06.015","article-title":"Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency","volume":"6","author":"Collet","year":"2017","journal-title":"Mol Metab."},{"issue":"3","key":"2022090808585008100_CIT0112","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1056\/NEJMoa1512693","article-title":"Proopiomelanocortin deficiency treated with a melanocortin-4 receptor agonist","volume":"375","author":"K\u00fchnen","year":"2016","journal-title":"N Engl J Med."},{"issue":"2","key":"2022090808585008100_CIT0113","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1021\/ml500340z","article-title":"Melanocortin antagonist tetrapeptides with minimal agonist activity at the mouse melanocortin-3 receptor","volume":"6","author":"Doering","year":"2015","journal-title":"ACS Med Chem Lett."},{"issue":"4","key":"2022090808585008100_CIT0114","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/apha.12394","article-title":"Activation of the brain melanocortin system is required for leptin-induced modulation of chemorespiratory function","volume":"213","author":"Bassi","year":"2015","journal-title":"Acta Physiol (Oxf)."},{"issue":"1","key":"2022090808585008100_CIT0115","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1164\/rccm.202002-0321OC","article-title":"Designer receptors exclusively activated by designer drugs approach to treatment of sleep-disordered breathing","volume":"203","author":"Fleury Curado","year":"2021","journal-title":"Am J Respir Crit Care Med."},{"issue":"4","key":"2022090808585008100_CIT0116","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1165\/rcmb.2020-0117OC","article-title":"Intranasal Leptin Prevents Opioid-induced Sleep-disordered Breathing in Obese Mice","volume":"63","author":"Freire","year":"2020","journal-title":"Am J Respir Cell Mol Biol."},{"issue":"1","key":"2022090808585008100_CIT0117","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/cphy.c100069","article-title":"Peripheral chemoreceptors: function and plasticity of the carotid body","volume":"2","author":"Kumar","year":"2012","journal-title":"Compr Physiol."},{"issue":"11","key":"2022090808585008100_CIT0118","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1161\/CIRCRESAHA.119.315338","article-title":"Leptin induces hypertension acting on transient receptor potential melastatin 7 channel in the carotid body","volume":"125","author":"Shin","year":"2019","journal-title":"Circ Res."},{"key":"2022090808585008100_CIT0119","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.peptides.2013.01.001","article-title":"Orexin: a potential role in the process of obstructive sleep apnea","volume":"42","author":"Wang","year":"2013","journal-title":"Peptides."},{"key":"2022090808585008100_CIT0120","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/B978-0-444-59489-1.00004-5","article-title":"Respiration and autonomic regulation and orexin","volume":"198","author":"Nattie","year":"2012","journal-title":"Prog Brain Res."},{"issue":"1","key":"2022090808585008100_CIT0121","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1152\/japplphysiol.00679.2006","article-title":"Vigilance state-dependent attenuation of hypercapnic chemoreflex and exaggerated sleep apnea in orexin knockout mice","volume":"102","author":"Nakamura","year":"2007","journal-title":"J Appl Physiol (1985)."},{"issue":"5","key":"2022090808585008100_CIT0122","doi-asserted-by":"crossref","first-page":"987","DOI":"10.5665\/sleep.3676","article-title":"Role of orexin in respiratory and sleep homeostasis during upper airway obstruction in rats","volume":"37","author":"Tarasiuk","year":"2014","journal-title":"Sleep."},{"key":"2022090808585008100_CIT0123","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.sleep.2020.05.034","article-title":"Intranasal oxytocin increases respiratory rate and reduces obstructive event duration and oxygen desaturation in obstructive sleep apnea patients: a randomized double blinded placebo controlled study","volume":"74","author":"Jain","year":"2020","journal-title":"Sleep Med."},{"issue":"4","key":"2022090808585008100_CIT0124","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1183\/09031936.00197610","article-title":"Role of growth hormone-releasing hormone in sleep and growth impairments induced by upper airway obstruction in rats","volume":"38","author":"Tarasiuk","year":"2011","journal-title":"Eur Respir J."},{"issue":"1","key":"2022090808585008100_CIT0125","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1467-789X.2006.00270.x","article-title":"The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review","volume":"8","author":"Klok","year":"2007","journal-title":"Obes Rev."},{"issue":"3","key":"2022090808585008100_CIT0126","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s11325-011-0552-7","article-title":"The influence of obesity and obstructive sleep apnea on metabolic hormones","volume":"16","author":"S\u00e1nchez-de-la-Torre","year":"2012","journal-title":"Sleep Breath."},{"issue":"3","key":"2022090808585008100_CIT0127","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1748-1716.2010.02142.x","article-title":"Exogenous ghrelin accentuates the acute hypoxic ventilatory response after two weeks of chronic hypoxia in conscious rats","volume":"200","author":"Schwenke","year":"2010","journal-title":"Acta Physiol (Oxf)."},{"issue":"9","key":"2022090808585008100_CIT0128","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsaa053","article-title":"Differential activating effects of thyrotropin-releasing hormone and its analog taltirelin on motor output to the tongue musculature in vivo","volume":"43","author":"Liu","year":"2020","journal-title":"Sleep."},{"issue":"8","key":"2022090808585008100_CIT0129","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1111\/dom.14726","article-title":"Therapeutic indications and metabolic effects of metreleptin in patients with lipodystrophy syndromes: real-life experience from a national reference network","volume":"24","author":"Mosbah","year":"2022","journal-title":"Diabetes Obes Metab."},{"issue":"3","key":"2022090808585008100_CIT0130","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10989-008-9139-y","article-title":"Drug development-targeted screening of leptin agonist glycopeptides","volume":"14","author":"Knappe","year":"2008","journal-title":"Int J Pept Res Ther."},{"issue":"5","key":"2022090808585008100_CIT0131","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1463-1326.2009.01170.x","article-title":"Leptin-based glycopeptide induces weight loss and simultaneously restores fertility in animal models","volume":"12","author":"Kovalszky","year":"2010","journal-title":"Diabetes Obes Metab."}],"container-title":["Sleep"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/sleep\/advance-article-pdf\/doi\/10.1093\/sleep\/zsac153\/44858063\/zsac153.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/sleep\/article-pdf\/45\/9\/zsac153\/45569498\/zsac153.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/sleep\/article-pdf\/45\/9\/zsac153\/45569498\/zsac153.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T05:04:47Z","timestamp":1662613487000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/sleep\/article\/doi\/10.1093\/sleep\/zsac153\/6627250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,2]]},"references-count":131,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,7,2]]},"published-print":{"date-parts":[[2022,9,8]]}},"URL":"https:\/\/doi.org\/10.1093\/sleep\/zsac153","relation":{},"ISSN":["0161-8105","1550-9109"],"issn-type":[{"value":"0161-8105","type":"print"},{"value":"1550-9109","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9,1]]},"published":{"date-parts":[[2022,7,2]]},"article-number":"zsac153"}}