{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T12:50:17Z","timestamp":1774875017458,"version":"3.50.1"},"reference-count":160,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T00:00:00Z","timestamp":1659225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL143790"],"award-info":[{"award-number":["R01 HL143790"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sleep occurs universally and is a biological necessity for human functioning. The consequences of diminished sleep quality impact physical and physiological systems such as neurological, cardiovascular, and metabolic processes. In fact, people impacted by common complex diseases experience a wide range of sleep disturbances. It is challenging to uncover the underlying molecular mechanisms responsible for decreased sleep quality in many disease systems owing to the lack of suitable sleep biomarkers. However, the discovery of a genetic component to sleep patterns has opened a new opportunity to examine and understand the involvement of sleep in many disease states. It is now possible to use major genomic resources and technologies to uncover genetic contributions to many common diseases. Large scale prospective studies such as the genome wide association studies (GWAS) have successfully revealed many robust genetic signals associated with sleep-related traits. With the discovery of these genetic variants, a major objective of the community has been to investigate whether sleep-related traits are associated with disease pathogenesis and other health complications. Mendelian Randomization (MR) represents an analytical method that leverages genetic loci as proxy indicators to establish causal effect between sleep traits and disease outcomes. Given such variants are randomly inherited at birth, confounding bias is eliminated with MR analysis, thus demonstrating evidence of causal relationships that can be used for drug development and to prioritize clinical trials. In this review, we outline the results of MR analyses performed to date on sleep traits in relation to a multitude of common complex diseases.<\/jats:p>","DOI":"10.1093\/sleep\/zsac180","type":"journal-article","created":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T05:59:07Z","timestamp":1659247147000},"source":"Crossref","is-referenced-by-count":13,"title":["Leveraging genetic discoveries for sleep to determine causal relationships with common complex traits"],"prefix":"10.1093","volume":"45","author":[{"given":"Shilpa","family":"Sonti","sequence":"first","affiliation":[{"name":"Center for Spatial and Functional Genomics, Children\u2019s Hospital of Philadelphia , Philadelphia, PA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2025-5302","authenticated-orcid":false,"given":"Struan F A","family":"Grant","sequence":"additional","affiliation":[{"name":"Center for Spatial and Functional Genomics, Children\u2019s Hospital of Philadelphia , Philadelphia, PA , USA"},{"name":"Department of Genetics, University of Pennsylvania , Philadelphia, PA , USA"},{"name":"Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA , USA"},{"name":"Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine , Philadelphia, PA , USA"},{"name":"Division of Human Genetics and Endocrinology, Children\u2019s Hospital of Philadelphia , Philadelphia, PA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,7,31]]},"reference":[{"issue":"19","key":"2022101005265325000_CIT0001","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1016\/j.cub.2017.08.014","article-title":"The jellyfish Cassiopea exhibits a sleep-like state","volume":"27","author":"Nath","year":"2017","journal-title":"Curr Biol."},{"issue":"1","key":"2022101005265325000_CIT0002","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5665\/sleep.3298","article-title":"Sleep health: can we define it? 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