{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:46:08Z","timestamp":1785941168021,"version":"3.56.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T00:00:00Z","timestamp":1664064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health","award":["RF-2016-02364742"],"award-info":[{"award-number":["RF-2016-02364742"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>Narcolepsy is a rare chronic central disorder of hypersomnolence with frequent endocrine-metabolic comorbidities. To address the complex care needs of patients during the COVID-19 emergency, we carried out a feasibility study of the TElemedicine for NARcolepsy (TENAR) protocol with the aim of assessing the feasibility of a multidisciplinary care approach via televisit for patients with narcolepsy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A feasibility single open-arm study on the multidisciplinary care of children (&amp;gt;7 y.o.) and adults with narcolepsy who required a follow-up visit was realized during the COVID-19 pandemic emergency period in Italy. The study included a sleep, metabolic, and psychosocial assessment via televisit at baseline, at 6, and at 12 months from the study inclusion period (15th May\u201326th June 2020).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total 39 out of 44 eligible patients (89%) entered the study (30 adults, nine children); 37 patients (95%) ended the 12-month follow-up. At baseline, the median Epworth sleepiness scale score (ESS) was 10 (IQR 8\u201314), and the median body mass index (BMI) was 25.6 (IQR 22.1\u201330.9). During the follow-up period, the ESS score decreased from the 6th month onward (p = 0.003), and BMI decreased at the 1-year follow-up (p = 0.047), while there were no differences in depressive and anxiety symptoms, quality of life, compliance with treatment, adverse drug reactions, or accidents.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>High response and retention rates, stability of ESS, and lack of side effects indicate that telemedicine is a feasible and safe approach for adults and children with narcolepsy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleep\/zsac228","type":"journal-article","created":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T10:58:05Z","timestamp":1664103485000},"source":"Crossref","is-referenced-by-count":8,"title":["Multidisciplinary care of patients with narcolepsy during coronavirus disease 2019 pandemic in Italy via televisit: the TElemedicine for NARcolepsy feasibility study"],"prefix":"10.1093","volume":"45","author":[{"given":"Fabio","family":"Pizza","sequence":"first","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna , Bologna , Italy"},{"name":"UO Epidemiologia e Statistica, IRCCS Istituto delle Scienze Neurologiche di Bologna , Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9051-7091","authenticated-orcid":false,"given":"Luca","family":"Vignatelli","sequence":"additional","affiliation":[{"name":"UO Epidemiologia e Statistica, IRCCS Istituto delle Scienze Neurologiche di Bologna , Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Oriolo","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna , Italy"},{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna , Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Zenesini","sequence":"additional","affiliation":[{"name":"UO Epidemiologia e Statistica, IRCCS Istituto delle Scienze Neurologiche di Bologna , Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9057-2883","authenticated-orcid":false,"given":"Anastasia","family":"Mangiaruga","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna , Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rossetti","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna , Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4316-5684","authenticated-orcid":false,"given":"Monica","family":"Moresco","sequence":"additional","affiliation":[{"name":"UO Epidemiologia e Statistica, IRCCS Istituto delle Scienze Neurologiche di Bologna , Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Vandi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna , Bologna , Italy"},{"name":"UO Epidemiologia e Statistica, IRCCS Istituto delle Scienze Neurologiche di Bologna , Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Citeroni","sequence":"additional","affiliation":[{"name":"UO Epidemiologia e Statistica, IRCCS Istituto delle Scienze Neurologiche di Bologna , Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uberto","family":"Pagotto","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna , Italy"},{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna , Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5194-375X","authenticated-orcid":false,"given":"Francesca","family":"Ingravallo","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna , Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Plazzi","sequence":"additional","affiliation":[{"name":"UO Epidemiologia e Statistica, IRCCS Istituto delle Scienze Neurologiche di Bologna , Bologna , Italy"},{"name":"Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia , Modena , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,25]]},"reference":[{"key":"2022121209201326000_CIT0001","volume-title":"International classification of sleep disorders","author":"American Academy of Sleep Medicine.","year":"2014","edition":"3"},{"key":"2022121209201326000_CIT0002","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.sleep.2014.01.015","article-title":"Delayed diagnosis of narcolepsy: characterization and impact","volume":"15","author":"Thorpy","year":"2014","journal-title":"Sleep Med."},{"key":"2022121209201326000_CIT0003","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s41582-019-0226-9","article-title":"Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment","volume":"15","author":"Bassetti","year":"2019","journal-title":"Nat Rev Neurol."},{"key":"2022121209201326000_CIT0004","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/jsr.12044","article-title":"Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study","volume":"22","author":"Luca","year":"2013","journal-title":"J Sleep Res."},{"key":"2022121209201326000_CIT0005","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1111\/ene.14888","article-title":"European guideline and expert statements on the management of narcolepsy in adults and children","volume":"28","author":"Bassetti","year":"2021","journal-title":"Eur J Neurol."},{"key":"2022121209201326000_CIT0006","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12883-020-01762-9","article-title":"Protocols of a diagnostic study and a randomized controlled non-inferiority trial comparing televisits vs standard in-person outpatient visits for narcolepsy diagnosis and care: TElemedicine for NARcolepsy (TENAR)","volume":"20","author":"Ingravallo","year":"2020","journal-title":"BMC Neurol."},{"key":"2022121209201326000_CIT0007","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.5664\/jcsm.5098","article-title":"American Academy of Sleep Medicine (AASM) position paper for the use of telemedicine for the diagnosis and treatment of sleep disorders","volume":"11","author":"Singh","year":"2015","journal-title":"J Clin Sleep Med."},{"key":"2022121209201326000_CIT0008","doi-asserted-by":"crossref","first-page":"180093","DOI":"10.1183\/16000617.0093-2018","article-title":"Telemedicine in the diagnosis and treatment of sleep apnoea","volume":"28","author":"Bruyneel","year":"2019","journal-title":"Eur Respir Rev."},{"key":"2022121209201326000_CIT0009","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.5664\/jcsm.9194","article-title":"The use of telemedicine for the diagnosis and treatment of sleep disorders: an American Academy of Sleep Medicine update","volume":"17","author":"Shamim-Uzzaman","year":"2021","journal-title":"J Clin Sleep Med."},{"key":"2022121209201326000_CIT0010","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1093\/jamia\/ocaa067","article-title":"Telehealth transformation: COVID-19 and the rise of virtual care","volume":"27","author":"Wosik","year":"2020","journal-title":"J Am Med Inform Assoc."},{"key":"2022121209201326000_CIT0011","doi-asserted-by":"crossref","first-page":"104878","DOI":"10.1016\/j.compbiomed.2021.104878","article-title":"Telehealth utilization during the Covid-19 pandemic: a systematic review","volume":"138","author":"Garfan","year":"2021","journal-title":"Comput Biol Med."},{"key":"2022121209201326000_CIT0012","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3390\/medicina57050462","article-title":"Outpatient telehealth implementation in the United States during the COVID-19 global pandemic: a systematic 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Behav."},{"key":"2022121209201326000_CIT0016","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s40814-016-0105-8","article-title":"CONSORT 2010 statement: extension to randomised pilot and feasibility trials","volume":"2","author":"Eldridge","year":"2016","journal-title":"Pilot Feasibility Stud."},{"key":"2022121209201326000_CIT0017","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s40814-019-0499-1","article-title":"Guidelines for reporting non-randomised pilot and feasibility studies","volume":"5","author":"Lancaster","year":"2019","journal-title":"Pilot Feasibility Stud."},{"key":"2022121209201326000_CIT0018","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.3390\/ijerph19042224","article-title":"Length of stay analysis of COVID-19 hospitalizations using a count regression model and Quantile regression: a study in Bologna, Italy","volume":"19","author":"Zeleke","year":"2022","journal-title":"Int J Environ Res Public 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