{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:53:12Z","timestamp":1783432392278,"version":"3.54.6"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T00:00:00Z","timestamp":1665792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-175056"],"award-info":[{"award-number":["PJT-175056"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN-143208"],"award-info":[{"award-number":["FDN-143208"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hewitt Foundation"},{"name":"Savoy Epilepsy Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>Whereas there is plenty of evidence on the influence of epileptic activity on non-rapid eye movement (NREM) sleep macro- and micro-structure, data on the impact of epilepsy on rapid eye movement (REM) sleep remains sparse. Using high-density electroencephalography (HD-EEG), we assessed global and focal disturbances of sawtooth waves (STW) as cortically generated sleep oscillations of REM sleep in patients with focal epilepsy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Twenty-two patients with drug-resistant focal epilepsy (13 females; mean age, 32.6 \u00b1 10.7 years; 12 temporal lobe epilepsy) and 12 healthy controls (3 females; 24.0 \u00b1 3.2 years) underwent combined overnight HD-EEG and polysomnography. STW rate, duration, frequency, power, spatial extent, IED rates and sleep homeostatic properties were analyzed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>STW rate and duration were reduced in patients with focal epilepsy compared to healthy controls (rate: 0.64\/min \u00b1 0.46 vs. 1.12\/min \u00b1 0.41, p = .005, d = \u22120.98; duration: 3.60 s \u00b1 0.76 vs. 4.57 \u00b1 1.00, p = .003, d = \u22121.01). Not surprisingly given the fronto-central maximum of STW, the reductions were driven by extratemporal lobe epilepsy patients (rate: 0.45\/min \u00b1 0.31 vs. 1.12\/min \u00b1 0.41, p = .0004, d = \u22121.35; duration: 3.49 s \u00b1 0.92 vs. 4.57 \u00b1 1.00, p = .017, d = \u22120.99) and were more pronounced in the first vs. the last sleep cycle (rate first cycle patients vs. controls: 0.60\/min \u00b1 0.49 vs. 1.10\/min \u00b1 0.55, p = .016, d = \u22120.90, rate last cycle patients vs. controls: 0.67\/min \u00b1 0.51 vs. 0.99\/min \u00b1 0.49, p = .11, d = \u22120.62; duration first cycle patients vs. controls: 3.60s \u00b1 0.76 vs. 4.57 \u00b1 1.00, p = .003, d = \u22121.01, duration last cycle patients vs. controls: 3.66s \u00b1 0.84 vs. 4.51 \u00b1 1.26, p = .039, d = \u22120.80). There was no regional decrease of STWs in the region with the epileptic focus vs. the contralateral side (all p &amp;gt; .05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Patients with focal epilepsy and in particular extratemporal lobe epilepsy show a global reduction of STW activity in REM sleep. This may suggest that epilepsy impacts cortically generated sleep oscillations even in REM sleep when epileptic activity is low.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleep\/zsac250","type":"journal-article","created":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T14:26:22Z","timestamp":1665843982000},"source":"Crossref","is-referenced-by-count":19,"title":["Focal epilepsy impacts rapid eye movement sleep microstructure"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2163-3857","authenticated-orcid":false,"given":"Katharina","family":"Schiller","sequence":"first","affiliation":[{"name":"Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University , Montreal , Canada"},{"name":"Hospital Group Ostallgaeu-Kaufbeuren, Department of Pediatrics , Kaufbeuren , Germany"},{"name":"Medical University Innsbruck, Department of Pediatrics , Innsbruck , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"von Ellenrieder","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute and Hospital, McGill University , Montreal , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamir","family":"Avigdor","sequence":"additional","affiliation":[{"name":"Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University , Montreal , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charbel","family":"El Kosseifi","sequence":"additional","affiliation":[{"name":"Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University , Montreal , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chifaou","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University , Montreal , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Minato","sequence":"additional","affiliation":[{"name":"Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University , Montreal , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Gotman","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute and Hospital, McGill University , Montreal , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Frauscher","sequence":"additional","affiliation":[{"name":"Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University , Montreal , Canada"},{"name":"Department of Medicine and Center for Neuroscience Studies, Queen\u2019s University; Kingston , Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,15]]},"reference":[{"key":"2023020806572981300_CIT0001","doi-asserted-by":"crossref","first-page":"107735","DOI":"10.1016\/j.yebeh.2020.107735","article-title":"Bidirectional relationships of sleep and epilepsy in adults with epilepsy","volume":"116","author":"Grigg-Damberger","year":"2021","journal-title":"Epilepsy Behav."},{"key":"2023020806572981300_CIT0002","first-page":"932790","article-title":"Why are seizures rare in rapid eye movement sleep? 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