{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:34:16Z","timestamp":1787009656586,"version":"build-2736575974"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study Objectives<\/jats:title>\n                    <jats:p>To evaluate sleep, sleepiness, and excessive need for sleep in patients with craniopharyngioma (a suprasellar tumor which can affect sleep\u2013wake systems).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study of all adult patients living with craniopharyngioma referred to the sleep clinic, who received a sleep interview, nocturnal polysomnography, multiple sleep latency tests (MSLT), and 18-h bed rest polysomnography. Their sleep measurements were compared with those of age- and sex-matched healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 54 patients screened with craniopharyngioma, 42 were analyzed, 80% of whom complained of excessive daytime sleepiness. Sleep testing revealed that 6 (14.3%) of them had secondary narcolepsy (including one with cataplexy), and 11 (26.2%) had central hypersomnia associated with a medical disorder. Compared with controls, patients were more frequently obese, had a shorter mean sleep latency on MSLT, and slept longer on the first night. There was a nonsignificant trend for patients with (vs. without) narcolepsy and hypersomnia to be younger, to have a higher body mass index, to be more likely to have received radiation therapy, and to have more severe damage to the hypothalamus after surgery. Treatment with stimulants (modafinil, pitolisant, and methylphenidate) was beneficial in 9\/10 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nearly half of the patients with craniopharyngioma and sleep disorders have a central disorder of hypersomnolence (narcolepsy and hypersomnia), which should be investigated and lead to considerations beyond sleep apnea syndrome in these obese patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleep\/zsad032","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T07:28:53Z","timestamp":1676618933000},"source":"Crossref","is-referenced-by-count":10,"title":["Hypersomnia and narcolepsy in 42 adult patients with craniopharyngioma"],"prefix":"10.1093","volume":"46","author":[{"given":"Pauline","family":"Dodet","sequence":"first","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris-Sorbonne (AP-HP-Sorbonne), H\u00f4pital la Piti\u00e9-Salp\u00eatri\u00e8re, Service des Pathologies du Sommeil et Centre de R\u00e9f\u00e9rence National des Narcolepsies et Hypersomnies rares , Paris , France"},{"name":"Sorbonne University and Paris Brain Institute (ICM) , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Noiray","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris-Sorbonne (AP-HP-Sorbonne), H\u00f4pital la Piti\u00e9-Salp\u00eatri\u00e8re, Service des Pathologies du Sommeil et Centre de R\u00e9f\u00e9rence National des Narcolepsies et Hypersomnies rares , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9556-4527","authenticated-orcid":false,"given":"Smaranda","family":"Leu-Semenescu","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris-Sorbonne (AP-HP-Sorbonne), H\u00f4pital la Piti\u00e9-Salp\u00eatri\u00e8re, Service des Pathologies du Sommeil et Centre de R\u00e9f\u00e9rence National des Narcolepsies et Hypersomnies rares , Paris , France"},{"name":"Sorbonne University and Paris Brain Institute (ICM) , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Lefevre","sequence":"additional","affiliation":[{"name":"Sorbonne University and Paris Brain Institute (ICM) , Paris , France"},{"name":"Neurosurgery Department, AP-HP-Sorbonne, H\u00f4pital la Piti\u00e9-Salp\u00eatri\u00e8re , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Nigam","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris-Sorbonne (AP-HP-Sorbonne), H\u00f4pital la Piti\u00e9-Salp\u00eatri\u00e8re, Service des Pathologies du Sommeil et Centre de R\u00e9f\u00e9rence National des Narcolepsies et Hypersomnies rares , Paris , France"},{"name":"Center for Advanced Research in Sleep Medicine, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al , Montr\u00e9al , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Faucher","sequence":"additional","affiliation":[{"name":"Department of Nutrition and National Reference Center for Rare Diseases: \u201cPrader-Willi Syndrome and other rare forms of obesity with eating disorders\u2019 (PRADORT),AP-HP-Sorbonne, H\u00f4pital la Piti\u00e9-Salp\u00eatri\u00e8re , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Maranci","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris-Sorbonne (AP-HP-Sorbonne), H\u00f4pital la Piti\u00e9-Salp\u00eatri\u00e8re, Service des Pathologies du Sommeil et Centre de R\u00e9f\u00e9rence National des Narcolepsies et Hypersomnies rares , Paris , France"},{"name":"Sorbonne University and Paris Brain Institute (ICM) , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"Jublanc","sequence":"additional","affiliation":[{"name":"Pituitary Unit, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique H\u00f4pitaux de Paris , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Poitou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and National Reference Center for Rare Diseases: \u201cPrader-Willi Syndrome and other rare forms of obesity with eating disorders\u2019 (PRADORT),AP-HP-Sorbonne, H\u00f4pital la Piti\u00e9-Salp\u00eatri\u00e8re , Paris , France"},{"name":"Nutrition and Obesity; 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