{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:09:57Z","timestamp":1792152597062,"version":"4.4.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011096","name":"Jazz pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Study Objectives<\/jats:title><jats:p>Symptomatic therapies for rapid-eye-movement (REM) sleep behavior disorder (RBD) are limited. Sodium oxybate (SXB), a gamma-aminobutyric acid (GABA)-B agonist, could be effective but has not been evaluated against placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This double-blind, parallel-group, randomized, placebo-controlled trial in 24 participants was conducted at the Stanford Sleep Center. Patients were adults with definite iRBD or Parkinson\u2019s disease and probable RBD (PD-RBD), and persistence of \u2265 2 weekly episodes despite standard therapy. Patients were randomized 1:1 to receive SXB during a 4-week titration followed by a 4-week stable dosing period. Primary outcome was number of monthly RBD episodes according to a diary filled by patients and partners. Secondary outcomes were severity, number of severe RBD episodes, and objective RBD activity on video polysomnography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve iRBD and 12 PD-RBD participated (mean 65.8 years), and 22 (n = 10 SXB, 12 placebo) completed the study. Although no significant between-group difference was found, SXB showed reduction of monthly RBD episodes by 23.1 (95% CI \u221236.0, \u221210.2; p = 0.001) versus 10.5 with placebo (95% CI, \u221222.6, 1.6; p = 0.087). Improvement from baseline was similarly observed for RBD overall severity burden (each episode weighted for severity), number of severe episodes, and objective RBD activity per video-polysomnography. Two participants receiving SXB withdrew due to anxiety and dizziness. The majority of adverse events are otherwise resolved with dose adjustment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SXB could reduce RBD symptoms; however, response was inconsistent and a large placebo effect was observed across patient-reported outcomes. Larger studies using objective endpoints are needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial<\/jats:title><jats:p>Treatment of REM Sleep Behavior Disorder (RBD) With Sodium Oxybate<\/jats:p><jats:p>https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04006925 ClinicalTrials.gov identifier: NCT04006925<\/jats:p><\/jats:sec>","DOI":"10.1093\/sleep\/zsad103","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T15:47:13Z","timestamp":1681400833000},"source":"Crossref","is-referenced-by-count":19,"title":["Sodium oxybate in treatment-resistant rapid-eye-movement sleep behavior disorder"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0539-5115","authenticated-orcid":false,"given":"Emmanuel H","family":"During","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Stanford University , Palo Alto, CA , USA"},{"name":"Department of Neurology and Neurological Sciences, Stanford 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