{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:17:33Z","timestamp":1791839853967,"version":"4.3.4"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Jiangsu Provincial Medical Key Discipline","award":["ZDXK202217"],"award-info":[{"award-number":["ZDXK202217"]}]},{"name":"Suzhou Clinical Research Center of Neurological Disease","award":["Szzx201503"],"award-info":[{"award-number":["Szzx201503"]}]},{"name":"Discipline Construction Program of the Second Affiliated Hospital Soochow University","award":["XKTJ-XK202001"],"award-info":[{"award-number":["XKTJ-XK202001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>Mounting evidence indicated the correlation between sleep and cerebral small vessel disease (CSVD). However, little is known about the exact causality between poor sleep and white matter injury, a typical signature of CSVD, as well as the underlying mechanisms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Spontaneously hypertensive rats (SHR) and control Wistar Kyoto rats were subjected to sleep fragmentation (SF) for 16 weeks. The effects of chronic sleep disruption on the deep white matter and cognitive performance were observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>SHR were validated as a rat model for CSVD. Fragmented sleep induced strain-dependent white matter abnormalities, characterized by reduced myelin integrity, impaired oligodendrocytes precursor cells (OPC) maturation and pro-inflammatory microglial polarization. Partially reversible phenotypes of OPC and microglia were observed in parallel following sleep recovery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Long-term SF-induced pathological effects on the deep white matter in a rat model of CSVD. The pro-inflammatory microglial activation and the block of OPC maturation may be involved in the mechanisms linking sleep to white matter injury.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleep\/zsad225","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T13:48:46Z","timestamp":1693230526000},"source":"Crossref","is-referenced-by-count":18,"title":["Effects of sleep fragmentation on white matter pathology in a rat model of cerebral small vessel disease"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6880-9779","authenticated-orcid":false,"given":"Xiang","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University , Suzhou , China"},{"name":"Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University , Suzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3272-2002","authenticated-orcid":false,"given":"Xiao-Jie","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University , Suzhou , China"},{"name":"Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University , Suzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University , Suzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University , Suzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University , Suzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University , Suzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Jie","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University , Suzhou , China"},{"name":"Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University , Suzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-Hong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University , Suzhou , China"},{"name":"Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University , Suzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University , Suzhou , China"},{"name":"Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University , Suzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8364-0219","authenticated-orcid":false,"given":"Chun-Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University , Suzhou , China"},{"name":"Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University , Suzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"issue":"7","key":"2024041200020654200_CIT0001","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S1474-4422(10)70104-6","article-title":"Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges","volume":"9","author":"Pantoni","year":"2010","journal-title":"Lancet Neurol."},{"issue":"5","key":"2024041200020654200_CIT0002","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1161\/01.STR.31.5.1062","article-title":"Ischemic stroke subtypes: a population-based study of functional outcome, survival, and recurrence","volume":"31","author":"Petty","year":"2000","journal-title":"Stroke."},{"issue":"11","key":"2024041200020654200_CIT0003","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.jalz.2018.04.007","article-title":"Cerebral small vessel disease and the risk of dementia: a systematic review and meta-analysis of population-based evidence","volume":"14","author":"Bos","year":"2018","journal-title":"Alzheimers Dement"},{"issue":"8","key":"2024041200020654200_CIT0004","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1136\/jnnp-2016-315324","article-title":"Prevalence, risk factors and consequences of cerebral small vessel diseases: data from three Asian countries","volume":"88","author":"Hilal","year":"2017","journal-title":"J Neurol Neurosurg Psychiatry."},{"issue":"7","key":"2024041200020654200_CIT0005","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1136\/jnnp.2006.103549","article-title":"Risk factor profile of cerebral small vessel disease and its subtypes","volume":"78","author":"Khan","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry."},{"issue":"5","key":"2024041200020654200_CIT0006","doi-asserted-by":"crossref","first-page":"709","DOI":"10.5665\/sleep.2632","article-title":"Obstructive sleep apnea as a risk factor for cerebral white matter change in a middle-aged and older general population","volume":"36","author":"Kim","year":"2013","journal-title":"Sleep."},{"issue":"4","key":"2024041200020654200_CIT0007","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsz264","article-title":"Association of obstructive sleep apnea and cerebral small vessel disease: a systematic review and meta-analysis","volume":"43","author":"Huang","year":"2020","journal-title":"Sleep."},{"issue":"11","key":"2024041200020654200_CIT0008","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1161\/01.STR.28.11.2222","article-title":"Nonhypertensive cerebral small-vessel disease. an autopsy study","volume":"28","author":"Lammie","year":"1997","journal-title":"Stroke."},{"issue":"17","key":"2024041200020654200_CIT0009","doi-asserted-by":"crossref","first-page":"6293","DOI":"10.3390\/ijms21176293","article-title":"Sleep as a novel biomarker and a promising therapeutic target for cerebral small vessel disease: a review focusing on Alzheimer\u2019s disease and the blood-brain barrier","volume":"21","author":"Semyachkina-Glushkovskaya","year":"2020","journal-title":"Int J Mol Sci ."},{"issue":"6156","key":"2024041200020654200_CIT0010","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1241224","article-title":"Sleep drives metabolite clearance from the adult brain","volume":"342","author":"Xie","year":"2013","journal-title":"Science."},{"key":"2024041200020654200_CIT0011","doi-asserted-by":"crossref","first-page":"101572","DOI":"10.1016\/j.smrv.2021.101572","article-title":"Sleep, cerebrospinal fluid, and the glymphatic system: a systematic review","volume":"61","author":"Chong","year":"2022","journal-title":"Sleep Med Rev."},{"issue":"3","key":"2024041200020654200_CIT0012","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jagp.2016.11.009","article-title":"Association of obstructive sleep apnea with episodic memory and cerebral microvascular pathology: a preliminary study","volume":"25","author":"Kerner","year":"2017","journal-title":"Am J Geriatr Psychiatry."},{"issue":"4","key":"2024041200020654200_CIT0013","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1161\/HYPERTENSIONAHA.115.05764","article-title":"Pathological effects of obstructive apneas during the sleep cycle in an animal model of cerebral small vessel disease","volume":"66","author":"Lloyd","year":"2015","journal-title":"Hypertension."},{"key":"2024041200020654200_CIT0014","volume-title":"Annual Sleep Report of China 2023","author":"Wang","year":"2023"},{"issue":"4","key":"2024041200020654200_CIT0015","doi-asserted-by":"crossref","first-page":"e345","DOI":"10.1212\/WNL.0000000000008739","article-title":"Sleep duration, midday napping, and sleep quality and incident stroke: the Dongfeng-Tongji cohort","volume":"94","author":"Zhou","year":"2020","journal-title":"Neurology."},{"issue":"12","key":"2024041200020654200_CIT0016","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1093\/eurheartj\/ehr007","article-title":"Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies","volume":"32","author":"Cappuccio","year":"2011","journal-title":"Eur Heart J."},{"key":"2024041200020654200_CIT0017","doi-asserted-by":"crossref","first-page":"882922","DOI":"10.3389\/fpsyt.2022.882922","article-title":"Neuropsychiatric symptoms and altered sleep quality in cerebral small vessel disease","volume":"13","author":"Li","year":"2022","journal-title":"Front Psychiatry."},{"issue":"4","key":"2024041200020654200_CIT0018","doi-asserted-by":"crossref","first-page":"e13538","DOI":"10.1111\/jsr.13538","article-title":"Poor sleep accelerates hippocampal and posterior cingulate volume loss in cognitively normal healthy older adults","volume":"31","author":"Liu","year":"2022","journal-title":"J Sleep Res."},{"key":"2024041200020654200_CIT0019","doi-asserted-by":"crossref","first-page":"751369","DOI":"10.3389\/fnagi.2021.751369","article-title":"Sleep quality mediates the association between cerebral small vessel disease burden and frailty: a community-based study","volume":"13","author":"Zhao","year":"2021","journal-title":"Front Aging Neurosci."},{"key":"2024041200020654200_CIT0020","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.sleep.2021.03.043","article-title":"MRI-visible perivascular space volumes, sleep duration and daytime dysfunction in adults with cerebrovascular disease","volume":"83","author":"Ramirez","year":"2021","journal-title":"Sleep Med."},{"issue":"10","key":"2024041200020654200_CIT0021","doi-asserted-by":"crossref","first-page":"e1462","DOI":"10.1212\/WNL.0000000000011377","article-title":"Slow-wave sleep and MRI markers of brain aging in a community-based sample","volume":"96","author":"Baril","year":"2021","journal-title":"Neurology."},{"issue":"1","key":"2024041200020654200_CIT0022","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12883-020-01647-x","article-title":"Non-breathing-related sleep fragmentation and imaging markers in patients with atherosclerotic cerebral small vessel disease (CSVD): a cross-sectional case-control study","volume":"20","author":"Wang","year":"2020","journal-title":"BMC Neurol."},{"issue":"6","key":"2024041200020654200_CIT0023","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsz298","article-title":"Sleep characteristics and white matter hyperintensities among midlife women","volume":"43","author":"Thurston","year":"2020","journal-title":"Sleep."},{"key":"2024041200020654200_CIT0024","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.sleep.2019.07.015","article-title":"Sleep and brain morphological changes in the eighth decade of life","volume":"65","author":"Aribisala","year":"2020","journal-title":"Sleep Med."},{"key":"2024041200020654200_CIT0025","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jpsychires.2019.02.002","article-title":"Sleep complaints and cerebral white matter: a prospective bidirectional study","volume":"112","author":"Kocevska","year":"2019","journal-title":"J Psychiatr Res."},{"issue":"8","key":"2024041200020654200_CIT0026","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.5664\/jcsm.7798","article-title":"On the association between sleep quality and arterial stiffness: a population study in community-dwelling older adults living in rural Ecuador (The Atahualpa Project)","volume":"15","author":"Del Brutto","year":"2019","journal-title":"J Clin Sleep Med."},{"issue":"9","key":"2024041200020654200_CIT0027","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1097\/WNR.0000000000001232","article-title":"White matter hyperintensity and cognitive impairments in chronic insomniacs","volume":"30","author":"Lu","year":"2019","journal-title":"Neuroreport."},{"key":"2024041200020654200_CIT0028","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.clineuro.2019.05.002","article-title":"Enlarged basal ganglia perivascular spaces and sleep parameters. A population-based study","volume":"182","author":"Del Brutto","year":"2019","journal-title":"Clin Neurol Neurosurg."},{"issue":"3","key":"2024041200020654200_CIT0029","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.slsci.2016.06.004","article-title":"The association between poor sleep quality and global cortical atrophy is related to age. Results from the Atahualpa Project","volume":"9","author":"Del Brutto","year":"2016","journal-title":"Sleep Sci."},{"issue":"9","key":"2024041200020654200_CIT0030","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.5665\/sleep.6104","article-title":"Sleep duration and white matter quality in middle-aged adults","volume":"39","author":"Yaffe","year":"2016","journal-title":"Sleep."},{"issue":"7","key":"2024041200020654200_CIT0031","doi-asserted-by":"crossref","first-page":"e0158758","DOI":"10.1371\/journal.pone.0158758","article-title":"Sleep apnea, sleep duration and brain MRI markers of cerebral vascular disease and Alzheimer\u2019s disease: the atherosclerosis risk in communities study (ARIC)","volume":"11","author":"Lutsey","year":"2016","journal-title":"PLoS One."},{"issue":"3","key":"2024041200020654200_CIT0032","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.sleep.2014.10.023","article-title":"Poor sleep quality and silent markers of cerebral small vessel disease: a population-based study in community-dwelling older adults (The Atahualpa Project)","volume":"16","author":"Del Brutto","year":"2015","journal-title":"Sleep Med."},{"issue":"5","key":"2024041200020654200_CIT0033","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/jsr.12177","article-title":"Sleep duration is associated with white matter hyperintensity volume in older adults: the Northern Manhattan Study","volume":"23","author":"Ramos","year":"2014","journal-title":"J Sleep Res."},{"issue":"3","key":"2024041200020654200_CIT0034","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1177\/0891988713493503","article-title":"Sleep disturbance correlates with white matter hyperintensity in patients with subcortical ischemic vascular dementia","volume":"26","author":"Cheng","year":"2013","journal-title":"J Geriatr Psychiatry Neurol."},{"issue":"3","key":"2024041200020654200_CIT0035","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/hbm.25695","article-title":"White matter hyperintensities segmentation using an ensemble of neural networks","volume":"43","author":"Li","year":"2022","journal-title":"Hum Brain Mapp."},{"key":"2024041200020654200_CIT0036","doi-asserted-by":"crossref","first-page":"c3666","DOI":"10.1136\/bmj.c3666","article-title":"The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis","volume":"341","author":"Debette","year":"2010","journal-title":"BMJ"},{"issue":"3","key":"2024041200020654200_CIT0037","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nrneurol.2015.10","article-title":"White matter hyperintensities, cognitive impairment and dementia: an update","volume":"11","author":"Prins","year":"2015","journal-title":"Nat Rev Neurol."},{"issue":"9","key":"2024041200020654200_CIT0038","doi-asserted-by":"crossref","first-page":"8506","DOI":"10.18632\/aging.103154","article-title":"White matter hyperintensities associated with progression of cerebral small vessel disease: a 7-year Chinese urban community study","volume":"12","author":"Xia","year":"2020","journal-title":"Aging."},{"issue":"6","key":"2024041200020654200_CIT0039","doi-asserted-by":"crossref","first-page":"001140","DOI":"10.1161\/JAHA.114.001140","article-title":"What are white matter hyperintensities made of? Relevance to vascular cognitive impairment","volume":"4","author":"Wardlaw","year":"2015","journal-title":"J Am Heart Assoc"},{"issue":"11","key":"2024041200020654200_CIT0040","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.3390\/cells8111424","article-title":"Oligodendrocytes in development, myelin generation and beyond","volume":"8","author":"Kuhn","year":"2019","journal-title":"Cells"},{"issue":"3","key":"2024041200020654200_CIT0041","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1152\/physrev.00031.2018","article-title":"Myelin in the central nervous system: structure, function, and pathology","volume":"99","author":"Stadelmann","year":"2019","journal-title":"Physiol Rev."},{"issue":"10","key":"2024041200020654200_CIT0042","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1212\/WNL.0000000000003687","article-title":"Early life risk factors for cerebrovascular disease: a systematic review and meta-analysis","volume":"88","author":"Backhouse","year":"2017","journal-title":"Neurology."},{"issue":"448","key":"2024041200020654200_CIT0043","doi-asserted-by":"crossref","first-page":"eaam9507","DOI":"10.1126\/scitranslmed.aam9507","article-title":"Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats","volume":"10","author":"Rajani","year":"2018","journal-title":"Sci Transl Med."},{"issue":"36","key":"2024041200020654200_CIT0044","doi-asserted-by":"crossref","first-page":"14288","DOI":"10.1523\/JNEUROSCI.5102-12.2013","article-title":"Effects of sleep and wake on oligodendrocytes and their precursors","volume":"33","author":"Bellesi","year":"2013","journal-title":"J Neurosci."},{"issue":"5","key":"2024041200020654200_CIT0045","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsy034","article-title":"Myelin modifications after chronic sleep loss in adolescent mice","volume":"41","author":"Bellesi","year":"2018","journal-title":"Sleep."},{"issue":"11","key":"2024041200020654200_CIT0046","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1002\/glia.23667","article-title":"The role of sleep and wakefulness in myelin plasticity","volume":"67","author":"de Vivo","year":"2019","journal-title":"Glia."},{"issue":"7","key":"2024041200020654200_CIT0047","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S1474-4422(19)30079-1","article-title":"Small vessel disease: mechanisms and clinical implications","volume":"18","author":"Wardlaw","year":"2019","journal-title":"Lancet Neurol."},{"issue":"21","key":"2024041200020654200_CIT0048","doi-asserted-by":"crossref","first-page":"5263","DOI":"10.1523\/JNEUROSCI.3981-16.2017","article-title":"Sleep loss promotes astrocytic phagocytosis and microglial activation in mouse cerebral cortex","volume":"37","author":"Bellesi","year":"2017","journal-title":"J Neurosci."},{"issue":"12","key":"2024041200020654200_CIT0049","doi-asserted-by":"crossref","first-page":"eaax7331","DOI":"10.1126\/sciadv.aax7331","article-title":"Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer\u2019s dementia","volume":"5","author":"Kaneshwaran","year":"2019","journal-title":"Sci Adv."},{"issue":"693","key":"2024041200020654200_CIT0050","doi-asserted-by":"crossref","first-page":"eade6285","DOI":"10.1126\/scitranslmed.ade6285","article-title":"Sleep deprivation exacerbates microglial reactivity and A\u03b2 deposition in a TREM2-dependent manner in mice","volume":"15","author":"Parhizkar","year":"2023","journal-title":"Sci Transl Med."},{"key":"2024041200020654200_CIT0051","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbi.2020.05.077","article-title":"Sleep loss disrupts pericyte-brain endothelial cell interactions impairing blood-brain barrier function","volume":"89","author":"Medina-Flores","year":"2020","journal-title":"Brain Behav Immun."},{"issue":"11","key":"2024041200020654200_CIT0052","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.5665\/sleep.4178","article-title":"Chronic sleep fragmentation induces endothelial dysfunction and structural vascular changes in mice","volume":"37","author":"Carreras","year":"2014","journal-title":"Sleep."},{"issue":"3","key":"2024041200020654200_CIT0053","doi-asserted-by":"crossref","first-page":"465","DOI":"10.5665\/sleep.3476","article-title":"Total sleep deprivation alters endothelial function in rats: a nonsympathetic mechanism","volume":"37","author":"Sauvet","year":"2014","journal-title":"Sleep."},{"key":"2024041200020654200_CIT0054","article-title":"Microglia regulation of central nervous system myelin health and regeneration","author":"Kent","year":"2023","journal-title":"Nat Rev Immunol."},{"issue":"9","key":"2024041200020654200_CIT0055","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nn.3469","article-title":"M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination","volume":"16","author":"Miron","year":"2013","journal-title":"Nat Neurosci."},{"issue":"1","key":"2024041200020654200_CIT0056","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s12974-022-02608-6","article-title":"Microglial-oligodendrocyte interactions in myelination and neurological function recovery after traumatic brain injury","volume":"19","author":"Song","year":"2022","journal-title":"J Neuroinflammation."},{"issue":"4","key":"2024041200020654200_CIT0057","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.ymthe.2020.12.009","article-title":"Microglial vesicles improve post-stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis","volume":"29","author":"Raffaele","year":"2021","journal-title":"Mol Ther."},{"issue":"1","key":"2024041200020654200_CIT0058","doi-asserted-by":"crossref","first-page":"6813","DOI":"10.1038\/s41467-022-34293-7","article-title":"Vascular endothelium deploys caveolin-1 to regulate oligodendrogenesis after chronic cerebral ischemia in mice","volume":"13","author":"Zhao","year":"2022","journal-title":"Nat Commun."},{"issue":"3","key":"2024041200020654200_CIT0059","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.neuron.2013.11.015","article-title":"Astrocyte-derived endothelin-1 inhibits remyelination through notch activation [published correction appears in Neuron. 2014 Mar 19;81(6):1442]","volume":"81","author":"Hammond","year":"2014","journal-title":"Neuron."},{"issue":"2","key":"2024041200020654200_CIT0060","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.neuron.2022.10.032","article-title":"Astrocyte endfoot formation controls the termination of oligodendrocyte precursor cell perivascular migration during development","volume":"111","author":"Su","year":"2023","journal-title":"Neuron."},{"key":"2024041200020654200_CIT0061","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s40478-014-0169-8","article-title":"Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease","volume":"2","author":"Kaiser","year":"2014","journal-title":"Acta Neuropathol Commun"},{"issue":"7744","key":"2024041200020654200_CIT0062","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41586-019-0948-2","article-title":"Sleep modulates haematopoiesis and protects against atherosclerosis","volume":"566","author":"McAlpine","year":"2019","journal-title":"Nature."},{"key":"2024041200020654200_CIT0063","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1742-2094-9-91","article-title":"Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-\u03b1 pathway","volume":"9","author":"Ramesh","year":"2012","journal-title":"J Neuroinflammation."},{"issue":"11","key":"2024041200020654200_CIT0064","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1164\/rccm.201107-1173OC","article-title":"Sleep fragmentation induces cognitive deficits via nicotinamide adenine dinucleotide phosphate oxidase-dependent pathways in mouse","volume":"184","author":"Nair","year":"2011","journal-title":"Am J Respir Crit Care Med."},{"issue":"15","key":"2024041200020654200_CIT0065","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1042\/CS20201017","article-title":"Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)","volume":"135","author":"Elmarakby","year":"2021","journal-title":"Clin Sci"},{"issue":"22","key":"2024041200020654200_CIT0066","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1016\/j.cell.2022.09.030","article-title":"SYK coordinates neuroprotective microglial responses in neurodegenerative disease","volume":"185","author":"Ennerfelt","year":"2022","journal-title":"Cell."},{"issue":"11","key":"2024041200020654200_CIT0067","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1038\/s41593-019-0514-0","article-title":"Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex","volume":"22","author":"Stowell","year":"2019","journal-title":"Nat Neurosci."},{"issue":"1","key":"2024041200020654200_CIT0068","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat Rev Neurosci."},{"issue":"5539","key":"2024041200020654200_CIT0069","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1126\/science.1062688","article-title":"Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice","volume":"293","author":"Drab","year":"2001","journal-title":"Science."},{"key":"2024041200020654200_CIT0070","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.expneurol.2015.03.017","article-title":"Demyelination as a rational therapeutic target for ischemic or traumatic brain injury","volume":"272","author":"Shi","year":"2015","journal-title":"Exp Neurol."},{"key":"2024041200020654200_CIT0071","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neuroimage.2019.04.063","article-title":"White matter microstructure disruptions mediate the adverse relationships between hypertension and multiple cognitive functions in cognitively intact older adults","volume":"197","author":"Luo","year":"2019","journal-title":"Neuroimage."},{"issue":"2","key":"2024041200020654200_CIT0072","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1177\/0271678X16635657","article-title":"Integrity of normal-appearing white matter: influence of age, visible lesion burden and hypertension in patients with small-vessel disease","volume":"37","author":"Mu\u00f1oz Maniega","year":"2017","journal-title":"J Cereb Blood Flow Metab."},{"issue":"4","key":"2024041200020654200_CIT0073","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/ana.24758","article-title":"A novel imaging marker for small vessel disease based on skeletonization of white matter tracts and diffusion histograms","volume":"80","author":"Baykara","year":"2016","journal-title":"Ann Neurol."},{"issue":"6583","key":"2024041200020654200_CIT0074","doi-asserted-by":"crossref","first-page":"eabh3021","DOI":"10.1126\/science.abh3021","article-title":"Hyperexcitable arousal circuits drive sleep instability during aging","volume":"375","author":"Li","year":"2022","journal-title":"Science."},{"key":"2024041200020654200_CIT0075","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1093\/sleep\/19.suppl_9.S61","article-title":"Sleep fragmentation in obstructive sleep apnea","volume":"19","author":"Kimoff","year":"1996","journal-title":"Sleep."},{"key":"2024041200020654200_CIT0076","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2147\/NSS.S295699","article-title":"Sleep-wake survival dynamics in people with insomnia","volume":"13","author":"Hermans","year":"2021","journal-title":"Nat Sci Sleep"},{"issue":"5","key":"2024041200020654200_CIT0077","doi-asserted-by":"crossref","first-page":"e0127351","DOI":"10.1371\/journal.pone.0127351","article-title":"Widespread changes in white matter microstructure after a day of waking and sleep deprivation","volume":"10","author":"Elvs\u00e5shagen","year":"2015","journal-title":"PLoS One."},{"issue":"31","key":"2024041200020654200_CIT0078","doi-asserted-by":"crossref","first-page":"12844","DOI":"10.1523\/JNEUROSCI.4520-12.2013","article-title":"Short-term learning induces white matter plasticity in the fornix","volume":"33","author":"Hofstetter","year":"2013","journal-title":"J Neurosci."},{"key":"2024041200020654200_CIT0079","doi-asserted-by":"crossref","first-page":"100916","DOI":"10.1016\/j.arr.2019.100916","article-title":"Inflammation and cerebral small vessel disease: a systematic review","volume":"53","author":"Low","year":"2019","journal-title":"Ageing Res Rev."},{"issue":"7","key":"2024041200020654200_CIT0080","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.neubiorev.2003.08.007","article-title":"The spontaneously hypertensive-rat as an animal model of ADHD: evidence for impulsive and non-impulsive subpopulations","volume":"27","author":"Adriani","year":"2003","journal-title":"Neurosci Biobehav Rev."}],"container-title":["SLEEP"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/sleep\/advance-article-pdf\/doi\/10.1093\/sleep\/zsad225\/51410487\/zsad225.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/sleep\/article-pdf\/47\/4\/zsad225\/57115937\/zsad225.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/sleep\/article-pdf\/47\/4\/zsad225\/57115937\/zsad225.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:03:10Z","timestamp":1712880190000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/sleep\/article\/doi\/10.1093\/sleep\/zsad225\/7252713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,28]]},"references-count":80,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,8,28]]},"published-print":{"date-parts":[[2024,4,12]]}},"URL":"https:\/\/doi.org\/10.1093\/sleep\/zsad225","relation":{},"ISSN":["0161-8105","1550-9109"],"issn-type":[{"value":"0161-8105","type":"print"},{"value":"1550-9109","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,4,1]]},"published":{"date-parts":[[2023,8,28]]},"article-number":"zsad225"}}