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The cognitive domains were episodic memory, verbal fluency, perceptual speed, executive functioning, and global cognition (aggregated measure). A series of mixed linear models were run separately in each study and then compared to assess the level and rate of change in cognitive functioning across each sleep disturbance parameter. Models were adjusted for age, sex, education, hypnotic usage, depressive symptoms, lifestyle factors, cardiovascular, and metabolic conditions. By using a coordinated analytic approach, comparable construct-level measurements were generated, and results from identical statistical models were qualitatively compared across studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>While the pattern of statistically significant results varied across studies, subjective sleep disturbances were consistently associated with worse cognition and steeper cognitive decline. Insomnia symptoms were associated with poorer episodic memory and participants sleeping less or more than 7\u20138 hours had a steeper decline in perceptual speed. In addition, daytime napping (&amp;gt;2 hours) was cross-sectionally and longitudinally associated with all examined cognitive domains. Most observed associations were study-specific (except for daytime napping), and a majority of association estimates remained significant after adjusting for covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This rigorous multicenter investigation further supports the importance of sleep disturbance, including insomnia, long and short sleep duration, and daytime napping on baseline cognitive functioning and rate of change among older adults. These sleep factors may be targeted in future lifestyle interventions to reduce cognitive decline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleep\/zsad244","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T09:06:59Z","timestamp":1694596019000},"source":"Crossref","is-referenced-by-count":45,"title":["Sleep disturbances and change in multiple cognitive domains among older adults: a multicenter study of five Nordic cohorts"],"prefix":"10.1093","volume":"47","author":[{"given":"Marieclaire","family":"Overton","sequence":"first","affiliation":[{"name":"Division of Geriatric Medicine, Department of Clinical Sciences in Malm\u00f6, Lund University, Sk\u00e5ne University Hospital , Malm\u00f6 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Skoog","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika J","family":"Laukka","sequence":"additional","affiliation":[{"name":"Aging Research Center (ARC), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University , Stockholm , Sweden"},{"name":"Stockholm Gerontology Research Center , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy Hadarsson","family":"Bodin","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Darin","family":"Mattsson","sequence":"additional","affiliation":[{"name":"Aging Research Center (ARC), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linnea","family":"Sj\u00f6berg","sequence":"additional","affiliation":[{"name":"Aging Research Center (ARC), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M","family":"Hofer","sequence":"additional","affiliation":[{"name":"Aging Research Center (ARC), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University , Stockholm , Sweden"},{"name":"Department of Neurology, Oregon Health & Science University , Portland, OR , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Johansson","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenni","family":"Kulmala","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet and Karolinska University Hospital , Stockholm , Sweden"},{"name":"Faculty of Social Sciences, Tampere University , Tampere , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miia","family":"Kivipelto","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet and Karolinska University Hospital , Stockholm , Sweden"},{"name":"Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London , London , UK"},{"name":"Theme Inflammation and Aging. Karolinska University Hospital , Stockholm , Sweden"},{"name":"Institute of Public Health and Clinical Nutrition, University of Eastern Finland , Kuopio , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Solomon","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet and Karolinska University Hospital , Stockholm , Sweden"},{"name":"Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London , London , UK"},{"name":"Theme Inflammation and Aging. 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