{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:12:33Z","timestamp":1792156353361,"version":"4.4.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>Narcolepsy type 2 (NT2) is an understudied central disorder of hypersomnolence sharing some similarities with narcolepsy type 1 and idiopathic hypersomnia (IH). We aimed: (1) to assess systematically the symptoms in patients with NT2, with self-reported questionnaires: Epworth Sleepiness Scale (ESS), Narcolepsy Severity Scale (NSS), IH Severity Scale (IHSS), and (2) to evaluate the responsiveness of these scales to treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>One hundred and nine patients with NT2 (31.4\u2005\u00b1\u200512.2 years old, 47 untreated) diagnosed according to ICSD-3 were selected in a Reference Center for Narcolepsy. They all completed the ESS, subgroups completed the modified NSS (NSS-2, without cataplexy items) (n\u2005=\u200595) and IHSS (n\u2005=\u200576). Some patients completed the scales twice (before\/during treatment): 42 ESS, 26 NSS-2, and 30 IHSS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Based on NSS-2, all untreated patients had sleepiness, 58% disrupted nocturnal sleep, 40% hallucinations, and 28% sleep paralysis. On IHSS, 76% reported a prolonged nocturnal sleep, and 83% sleep inertia. In the independent sample, ESS and NSS-2 scores were lower in treated patients, with same trend for IHSS scores. After treatment, ESS, NSS-2, and IHSS total scores were lower, with a mean difference of 3.7\u2005\u00b1\u20054.1, 5.3\u2005\u00b1\u20056.7, and 4.1\u2005\u00b1\u20056.2, respectively. The minimum clinically important difference between untreated and treated patients were 2.1 for ESS, 3.3 for NSS-2, and 3.1 for IHSS. After treatment, 61.9% of patients decreased their ESS\u2005&amp;gt;\u20052 points, 61.5% their NSS-2\u2005&amp;gt;\u20053 points, and 53.3% their IHSS\u2005&amp;gt;\u20053 points.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>NSS-2 and IHSS correctly quantified symptoms' severity and consequences in NT2, with good performances to objectify response to medications. These tools are useful for monitoring and optimizing NT2 management, and for use in clinical trials.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleep\/zsad323","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T14:29:31Z","timestamp":1704896971000},"source":"Crossref","is-referenced-by-count":30,"title":["Narcolepsy Severity Scale-2 and Idiopathic Hypersomnia Severity Scale to better quantify symptoms severity and consequences in Narcolepsy type 2"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6620-5127","authenticated-orcid":false,"given":"Lucie","family":"Barateau","sequence":"first","affiliation":[{"name":"Sleep-Wake Disorders Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier , France"},{"name":"National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome , Montpellier , France"},{"name":"Institut des Neurosciences de Montpellier, University of Montpellier, Inserm-UM 1298 , Montpellier , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9545-4958","authenticated-orcid":false,"given":"Sofiene","family":"Chenini","sequence":"additional","affiliation":[{"name":"Sleep-Wake Disorders Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier , France"},{"name":"National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome , Montpellier , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Denis","sequence":"additional","affiliation":[{"name":"Sleep-Wake Disorders Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Lorber","sequence":"additional","affiliation":[{"name":"Sleep-Wake Disorders Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"B\u00e9ziat","sequence":"additional","affiliation":[{"name":"Institut des Neurosciences de Montpellier, University of Montpellier, Inserm-UM 1298 , Montpellier , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8205-7590","authenticated-orcid":false,"given":"Isabelle","family":"Jaussent","sequence":"additional","affiliation":[{"name":"Institut des Neurosciences de Montpellier, University of Montpellier, Inserm-UM 1298 , Montpellier , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0683-6506","authenticated-orcid":false,"given":"Yves","family":"Dauvilliers","sequence":"additional","affiliation":[{"name":"Sleep-Wake Disorders Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier , France"},{"name":"National Reference Centre for Orphan 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