{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:30:05Z","timestamp":1791203405398,"version":"4.2.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Australian Government Research Training Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study Objectives<\/jats:title>\n                    <jats:p>Little is known about the interrelationships between sleep regularity, obstructive sleep apnea (OSA) and important health markers. This study examined whether irregular sleep is associated with OSA and hypertension, and if this modifies the known association between OSA and hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Six hundred and two adults (age mean(SD)\u2005=\u200556.96(5.51) years, female\u2005=\u200560%) from the Raine Study who were not evening or night shift workers were assessed for OSA (in-laboratory polysomnography; apnea\u2013hypopnea index\u2005\u2265\u200515 events\/hour), hypertension (doctor diagnosed, or systolic blood pressure \u2265140 mmHg and\/or diastolic \u226590 mmHg) and sleep (wrist actigraphy for \u22655 days). A sleep regularity index (SRI) was determined from actigraphy. Participants were categorized by tertiles as severely irregular, mildly irregular, or regular sleepers. Logistic regression models examined the interrelationships between SRI, OSA and hypertension. Covariates included age, sex, body mass index, actigraphy sleep duration, insomnia, depression, activity, alcohol, smoking, and antihypertensive medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to regular sleepers, participants with mildly irregular (OR 1.97, 95% confidence intervals [CI] 1.20 to 3.27) and severely irregular (OR 2.06, 95% CI: 1.25 to 3.42) sleep had greater odds of OSA. Compared to those with no OSA and regular sleep, OSA and severely irregular sleep combined had the highest odds of hypertension (OR 2.34 95% CI: 1.07 to 5.12; p for interaction\u2005=\u20050.02) while those with OSA and regular\/mildly irregular sleep were not at increased risk (p for interaction\u2005=\u20050.20).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sleep irregularity may be an important modifiable target for hypertension among those with OSA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleep\/zsae001","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:32:26Z","timestamp":1704328346000},"source":"Crossref","is-referenced-by-count":28,"title":["The interrelationships between sleep regularity, obstructive sleep apnea, and hypertension in a middle-aged community population"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1343-9552","authenticated-orcid":false,"given":"Kelly","family":"Sansom","sequence":"first","affiliation":[{"name":"Centre for Sleep Science, School of Human Sciences, University of Western Australia , Perth, WA , Australia"},{"name":"Queen Elizabeth II Medical Centre, West Australian Sleep Disorders Research Institute , Nedlands, WA , Australia"},{"name":"Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute - Sleep Health , Adelaide, SA , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9534-8699","authenticated-orcid":false,"given":"Amy","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute - Sleep Health , Adelaide, SA , 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Singapore University of Social Sciences , Clementi , Singapore"},{"name":"Duke-NUS Medical School, National University of Singapore , Singapore"},{"name":"Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia , Pulau Pinang , Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3950-6079","authenticated-orcid":false,"given":"Jennifer","family":"Walsh","sequence":"additional","affiliation":[{"name":"Centre for Sleep Science, School of Human Sciences, University of Western Australia , Perth, WA , Australia"},{"name":"Queen Elizabeth II Medical Centre, West Australian Sleep Disorders Research Institute , Nedlands, WA , Australia"},{"name":"Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital , Perth, WA , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Maddison","sequence":"additional","affiliation":[{"name":"Centre for Sleep 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