{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:31:31Z","timestamp":1792794691329,"version":"4.5.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"6","funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study Objectives<\/jats:title>\n                    <jats:p>Rapid eye movement sleep behavior disorder (RBD) is strongly associated with phenoconversion to an overt synucleinopathy, e.g. Parkinson\u2019s disease (PD), Lewy body dementia, and related disorders. Comorbid traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD)\u2014henceforth \u201cneurotrauma\u201d (NT)\u2014increase the odds of RBD by ~2.5-fold and are associated with an increased rate of service-connected PD in Veterans. Thus, RBD and NT are both independently associated with PD; however, it is unclear how NT influences neurological function in patients with RBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants \u226518 years with overnight polysomnogram-confirmed RBD were enrolled between 8\/2018 to 4\/2021 through the North American Prodromal Synucleinopathy Consortium. Standardized assessments for RBD, TBI, and PTSD history, as well as cognitive, motor, sensory, and autonomic function, were completed. This cross-sectional analysis compared cases (n\u2005=\u200524; RBD\u2005+\u2005NT) to controls (n\u2005=\u200596; RBD), matched for age (~60 years), sex (15% female), and years of education (~15 years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>RBD\u2005+\u2005NT reported earlier RBD symptom onset (37.5\u2005\u00b1\u200511.9 vs. 52.2\u2005\u00b1\u200515.1 years of age) and a more severe RBD phenotype. Similarly, RBD\u2005+\u2005NT reported more severe anxiety and depression, greater frequency of hypertension, and significantly worse cognitive, motor, and autonomic function compared to RBD. No differences in olfaction or color vision were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This cross-sectional, matched case:control study shows individuals with RBD\u2005+\u2005NT have significantly worse neurological measures related to common features of an overt synucleinopathy. Confirmatory longitudinal studies are ongoing; however, these results suggest RBD\u2005+\u2005NT may be associated with more advanced neurological symptoms related to an evolving neurodegenerative process.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleep\/zsae007","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:32:33Z","timestamp":1704328353000},"source":"Crossref","is-referenced-by-count":14,"title":["Comorbid neurotrauma increases neurodegenerative-relevant cognitive, motor, and autonomic dysfunction in patients with rapid eye movement sleep behavior disorder: a substudy of the North American Prodromal Synucleinopathy Consortium"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6992-6851","authenticated-orcid":false,"given":"Jonathan E","family":"Elliott","sequence":"first","affiliation":[{"name":"VA Portland Health Care System, Research Service , Portland, OR 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