{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:33:19Z","timestamp":1792762399301,"version":"4.5.0"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["UG3 DA048734"],"award-info":[{"award-number":["UG3 DA048734"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>Opioid withdrawal is an aversive experience that often exacerbates depressive symptoms and poor sleep. The aims of the present study were to examine the effects of suvorexant on oscillatory sleep-electroencephalography (EEG) band power during medically managed opioid withdrawal, and to examine their association with withdrawal severity and depressive symptoms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Participants with opioid use disorder (N\u2005=\u200538: age-range:21\u201363, 87% male, 45% white) underwent an 11-day buprenorphine taper, in which they were randomly assigned to suvorexant (20 mg [n\u2005=\u200514] or 40 mg [n\u2005=\u200512]), or placebo [n\u2005=\u200512], while ambulatory sleep-EEG data was collected. Linear mixed-effect models were used to explore: (1) main and interactive effects of drug group, and time on sleep-EEG band power, and (2) associations between sleep-EEG band power change, depressive symptoms, and withdrawal severity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Oscillatory spectral power tended to be greater in the suvorexant groups. Over the course of the study, decreases in delta power were observed in all study groups (\u03b2\u2005=\u2005\u2212189.082, d\u2005=\u2005\u22120.522, p\u2005=\u2005&amp;lt;0.005), increases in beta power (20 mg: \u03b2\u2005=\u20052.579, d\u2005=\u20050.413, p\u2005=\u20050.009 | 40 mg \u03b2\u2005=\u20055.265, d\u2005=\u20050.847, p\u2005&amp;lt;\u20050.001) alpha power (20 mg: \u03b2\u2005=\u2005158.304, d\u2005=\u20050.397, p\u2005=\u20050.009 | 40 mg: \u03b2\u2005=\u2005250.212, d\u2005=\u20050.601, p\u2005=\u20050.001) and sigma power (20 mg: \u03b2\u2005=\u200548.97, d\u2005=\u20050.410, p\u2005&amp;lt;\u20050.001 | 40 mg: \u03b2\u2005=\u200571.54, d\u2005=\u20050.568, p\u2005&amp;lt;\u20050.001) were observed in the two suvorexant groups. During the four-night taper, decreases in delta power were associated with decreases in depressive symptoms (20 mg: \u03b2\u2005=\u2005190.90, d\u2005=\u20050.308, p\u2005=\u20050.99 | 40 mg: \u03b2\u2005=\u2005433.33, d\u2005=\u20050.889 p\u2005=\u2005&amp;lt;0.001), and withdrawal severity (20 mg: \u03b2\u2005=\u2005215.55, d\u2005=\u20050.034, p\u2005=\u20050.006 | 40 mg: \u03b2\u2005=\u2005192.64, d\u2005=\u2005\u22120.854, p\u2005=\u2005&amp;lt;0.001), in both suvorexant groups and increases in sigma power were associated with decreases in withdrawal severity (20 mg: \u03b2\u2005=\u2005\u2212357.84, d\u2005=\u2005\u22120.659, p\u2005=\u20050.004 | 40 mg: \u03b2\u2005=\u2005\u2212906.35, d\u2005=\u2005\u22121.053, p\u2005=\u2005&amp;lt;0.001). Post-taper decreases in delta (20 mg: \u03b2\u2005=\u2005740.58, d\u2005=\u20050.964 p\u2005=\u2005&amp;lt;0.001 | 40 mg: \u03b2\u2005=\u2005662.23, d\u2005=\u20050.882, p\u2005=\u2005&amp;lt;0.001) and sigma power (20 mg only: \u03b2\u2005=\u2005335.54, d\u2005=\u20050.560, p\u2005=\u20050.023) were associated with reduced depressive symptoms in the placebo group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Results highlight a complex and nuanced relationship between sleep-EEG power and symptoms of depression and withdrawal. Changes in delta power may represent a mechanism influencing depressive symptoms and withdrawal.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleep\/zsae025","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T08:07:14Z","timestamp":1706602034000},"source":"Crossref","is-referenced-by-count":9,"title":["Suvorexant alters dynamics of the sleep-electroencephalography-power spectrum and depressive-symptom trajectories during inpatient opioid withdrawal"],"prefix":"10.1093","volume":"47","author":[{"given":"Matthew J","family":"Reid","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly E","family":"Dunn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine , Baltimore, MD , 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Medicine , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7525-4801","authenticated-orcid":false,"given":"Patrick H","family":"Finan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine , Baltimore, MD , USA"},{"name":"Department of Anesthesiology, University of Virginia School of Medicine , Charlottesville, VA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8073-7701","authenticated-orcid":false,"given":"Andrew S","family":"Huhn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral 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