{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:00:06Z","timestamp":1790442006123,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG050507"],"award-info":[{"award-number":["R01AG050507"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030692","name":"Intramural Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN-260-2004-00012C."],"award-info":[{"award-number":["HHSN-260-2004-00012C."]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>To compare sleep and 24-hour rest\/activity rhythms (RARs) between cognitively normal older adults who are \u03b2-amyloid-positive (A\u03b2+) or A\u03b2\u2212 and replicate a novel time-of-day-specific difference between these groups identified in a previous exploratory study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We studied 82 cognitively normal participants from the Baltimore Longitudinal Study of Aging (aged 75.7\u2005\u00b1\u20058.5 years, 55% female, 76% white) with wrist actigraphy data and A\u03b2+ versus A\u03b2\u2212 status measured by [11C] Pittsburgh compound B positron emission tomography. RARs were calculated using epoch-level activity count data from actigraphy. We used novel, data-driven function-on-scalar regression analyses and standard RAR metrics to cross-sectionally compare RARs between 25 A\u03b2+ and 57 A\u03b2\u2212 participants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Compared to A\u03b2\u2212 participants, A\u03b2+ participants had higher mean activity from 1:00 p.m. to 3:30 p.m. when using less conservative pointwise confidence intervals (CIs) and from 1:30 p.m. to 2:30 p.m. using more conservative, simultaneous CIs. Furthermore, A\u03b2+ participants had higher day-to-day variability in activity from 9:00 a.m. to 11:30 a.m. and lower variability from 1:30 p.m. to 4:00 p.m. and 7:30 p.m. to 10:30 p.m. according to pointwise CIs, and lower variability from 8:30 p.m. to 10:00 p.m. using simultaneous CIs. There were no A\u03b2-related differences in standard sleep or RAR metrics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Findings suggest A\u03b2+ older adults have higher, more stable day-to-day afternoon\/evening activity than A\u03b2\u2212 older adults, potentially reflecting circadian dysfunction. Studies are needed to replicate our findings and determine whether these or other time-of-day-specific RAR features have utility as markers of preclinical A\u03b2 deposition and if they predict clinical dementia and agitation in the afternoon\/evening (i.e. \u201csundowning\u201d).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleep\/zsae037","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T16:54:10Z","timestamp":1708534450000},"source":"Crossref","is-referenced-by-count":10,"title":["Evaluating a novel 24-hour rest\/activity rhythm marker of preclinical \u03b2-amyloid deposition"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1507-0995","authenticated-orcid":false,"given":"Adam P","family":"Spira","sequence":"first","affiliation":[{"name":"Department of Mental Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD , USA"},{"name":"Department of Psychiatry and Behavioral Sciences, 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