{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:50:11Z","timestamp":1792612211099,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>This study aimed to identify electroencephalographic (EEG) spectro-spatial covariance patterns associated with phenoconversion in isolated rapid eye movement sleep behavior disorder (iRBD) patients and explore their longitudinal trajectories within \u03b1-synucleinopathies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We assessed 47 participants, including 35 patients with iRBD and 12 healthy controls (HC), through baseline eye-closed resting EEGs. Patients with iRBD underwent follow-up EEG assessments and 18 patients with iRBD converted (12 to Parkinson\u2019s disease (PD), 6 to dementia with Lewy bodies [DLB]) during follow-up. We derived EEG spectro-spatial covariance patterns for PD-RBD and DLB-RBD from converters and HC. Correlations with motor and cognitive function, baseline distinctions among iRBD converters and nonconverters, and longitudinal trajectories were examined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>At baseline, converters exhibited higher PD-RBD and DLB-RBD beta2 pattern scores compared to nonconverters (each area under curve [AUC]\u2005=\u20050.7751). The delta and alpha spatial patterns effectively distinguished both PD and DLB converters from HC, with the alpha pattern showing high discriminative power (AUC\u2005=\u20050.9097 for PD-RBD, 0.9306 for DLB-RBD). Movement Disorder Society-Sponsored Revision of the Unified Parkinson\u2019s Disease Rating Scale part III scores correlated positively with PD-RBD and DLB-RBD delta patterns (Spearman\u2019s rho\u2005=\u20050.688, p\u2005=\u20050.00014; rho\u2005=\u20050.539, p\u2005=\u20050.0055, respectively), with age and sex as cofactors. Distinct trajectories emerged during follow-up among PD converters, DLB converters, and iRBD nonconverters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Unique EEG spectro-spatial patterns specific to PD-RBD and DLB-RBD offer potential as predictive markers for phenoconversion to \u03b1-synucleinopathies in iRBD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleep\/zsae052","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T10:12:08Z","timestamp":1710411128000},"source":"Crossref","is-referenced-by-count":8,"title":["Electroencephalographic spectro-spatial covariance patterns related to phenoconversion in isolated rapid eye movement sleep behavior disorder and their longitudinal trajectories in \u03b1-synucleinopathies"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7219-536X","authenticated-orcid":false,"given":"Kyoungeun","family":"Park","sequence":"first","affiliation":[{"name":"Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hwan","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Ick","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kyung Hee University Hospital at Gangdong , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El","family":"Jeong","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5528-9081","authenticated-orcid":false,"given":"Ki-Young","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine , Seoul , South Korea"},{"name":"Sensory Organ Research Institute, Seoul National University Medical Research Center, Seoul, South Korea; 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