{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:36:58Z","timestamp":1790879818007,"version":"4.1.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study Objectives<\/jats:title>\n                    <jats:p>Apolipoprotein E \u025b4 (APOE4) is the strongest genetic risk factor for Alzheimer\u2019s disease (AD). In addition, APOE4 carriers may exhibit sleep disturbances, but conflicting results have been reported, such that there is no clear consensus regarding which aspects of sleep are impacted. Our objective was to compare objective sleep architecture between APOE4 carriers and non-carriers, and to investigate the modulating impact of age, sex, cognitive status, and obstructive sleep apnea (OSA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 198 dementia-free participants aged &amp;gt;55 years old (mean age: 68.7 \u00b1 8.08 years old, 40.91% women, 41 APOE4 carriers) were recruited in this cross-sectional study. They underwent polysomnography, APOE4 genotyping, and a neuropsychological evaluation. ANCOVAs assessed the effect of APOE4 status on sleep architecture, controlling for age, sex, cognitive status, and the apnea\u2013hypopnea index. Interaction terms were added between APOE4 status and covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Rapid eye movement (REM) sleep percentage (F\u2005=\u20059.95, p\u2005=\u2005.002, \u03b7p2\u2005=\u20050.049) and duration (F\u2005=\u20059.23, p\u2005=\u2005.003, \u03b7p2\u2005=\u20050.047) were lower in APOE4 carriers. The results were replicated in a subsample of 112 participants without moderate-to-severe OSA. There were no significant interactions between APOE4 status and age, sex, cognitive status, and OSA in the whole sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results show that APOE4 carriers exhibit lower REM sleep duration, including in cognitively unimpaired individuals, possibly resulting from early neurodegenerative processes in regions involved in REM sleep generation and maintenance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sleep\/zsae094","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T19:58:29Z","timestamp":1713383909000},"source":"Crossref","is-referenced-by-count":23,"title":["Reduced rapid eye movement sleep in late middle-aged and older apolipoprotein E\n                    <b>\u025b<\/b>\n                    4 allele carriers"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7077-1108","authenticated-orcid":false,"given":"Claire","family":"Andr\u00e9","sequence":"first","affiliation":[{"name":"Center for Advanced Research in Sleep Medicine, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Recherche CIUSSS NIM , Montreal, QC , Canada"},{"name":"Department of Psychology, Universit\u00e9 de Montr\u00e9al , Montreal, QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-\u00c8ve","family":"Martineau-Dussault","sequence":"additional","affiliation":[{"name":"Center for Advanced Research in Sleep Medicine, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Recherche CIUSSS NIM , Montreal, QC , Canada"},{"name":"Department of Psychology, Universit\u00e9 de Montr\u00e9al , Montreal, QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9e-Ann","family":"Baril","sequence":"additional","affiliation":[{"name":"Center for Advanced Research in Sleep Medicine, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Recherche CIUSSS NIM , Montreal, QC , Canada"},{"name":"Department of Medicine, Universit\u00e9 de Montr\u00e9al , Montreal, QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7809-4399","authenticated-orcid":false,"given":"Nicola Andrea","family":"Marchi","sequence":"additional","affiliation":[{"name":"Center for Advanced Research in Sleep Medicine, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Recherche CIUSSS NIM , Montreal, QC , Canada"},{"name":"Department of Psychology, Universit\u00e9 de Montr\u00e9al , Montreal, QC , Canada"},{"name":"Center for Investigation and Research in Sleep, Department of Medicine, Lausanne University Hospital and University of Lausanne , Lausanne , Switzerland"},{"name":"Laboratory for Research in Neuroimaging, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne , Lausanne , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Daneault","sequence":"additional","affiliation":[{"name":"Center for Advanced Research in Sleep Medicine, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Recherche CIUSSS NIM , Montreal, QC , Canada"},{"name":"Department of Psychology, Universit\u00e9 de Montr\u00e9al , Montreal, QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Lorrain","sequence":"additional","affiliation":[{"name":"Research Centre on Aging, University Institute of Geriatrics of Sherbrooke, CIUSSS de l\u2019Estrie-CHUS , Sherbrooke, QC , Canada"},{"name":"Department of Psychology, Universit\u00e9 de Sherbrooke , Sherbrooke, QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7554-3187","authenticated-orcid":false,"given":"Carol","family":"Hudon","sequence":"additional","affiliation":[{"name":"CERVO Brain Research Centre, Institut Universitaire en Sant\u00e9 Mentale de Qu\u00e9bec , Qu\u00e9bec City, QC , Canada"},{"name":"School of Psychology, Universit\u00e9 Laval , Qu\u00e9bec City, QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9236-9125","authenticated-orcid":false,"given":"C\u00e9lyne H","family":"Bastien","sequence":"additional","affiliation":[{"name":"CERVO Brain Research Centre, Institut Universitaire en Sant\u00e9 Mentale de Qu\u00e9bec , Qu\u00e9bec City, QC , Canada"},{"name":"School of Psychology, Universit\u00e9 Laval , Qu\u00e9bec City, QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Petit","sequence":"additional","affiliation":[{"name":"Center for Advanced Research in Sleep Medicine, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Recherche CIUSSS NIM , Montreal, QC , Canada"},{"name":"Department of Psychiatry, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0016-4753","authenticated-orcid":false,"given":"Cynthia","family":"Thompson","sequence":"additional","affiliation":[{"name":"Center for Advanced Research in Sleep Medicine, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Recherche CIUSSS NIM , Montreal, QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judes","family":"Poirier","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, McGill University , Montreal, QC , Canada"},{"name":"Douglas Mental Health 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5311-2370","authenticated-orcid":false,"given":"Julie","family":"Carrier","sequence":"additional","affiliation":[{"name":"Center for Advanced Research in Sleep Medicine, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Recherche CIUSSS NIM , Montreal, QC , Canada"},{"name":"Department of Psychology, Universit\u00e9 de Montr\u00e9al , Montreal, QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"issue":"3","key":"2024071105513200900_CIT0001","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41588-019-0358-2","article-title":"Genetic meta-analysis of diagnosed Alzheimer\u2019s disease identifies new risk loci and implicates A\u03b2, tau, immunity and lipid processing","volume":"51","author":"Kunkle","year":"2019","journal-title":"Nat 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