{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T19:59:04Z","timestamp":1767902344231,"version":"3.49.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170098"],"award-info":[{"award-number":["82170098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>To investigate the engagement and health outcomes of community-based intervention for obstructive sleep apnea (OSA) in the general population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a 3-month randomized controlled trial in two communities in southern China. We initially screened the general population for high-risk OSA and further diagnosis using home sleep testing. Eligible participants were randomly (1:1) assigned to either a control or continuous positive airway pressure-based integrated intervention group. The primary outcomes were multimodal indicators reflecting health outcomes, including health-related quality of life (Short Form-36 [SF-36]), sleep-related symptoms, and cardiometabolic risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 2484 participants screened, 1423 identified as having high-risk OSA were considered for telephone invitations to participate in the trial. Of these, 401 participants responded positively (28.2%), 279 were diagnosed with OSA, and 212 were randomized. The intervention significantly improved several domains of SF-36, including physical functioning (intergroup difference, 2.8; p\u2005=\u2005.003), vitality (2.3; p\u2005=\u2005.031), and reported health transition (6.8; p\u2005=\u2005.005). Sleep-related symptoms, including Epworth Sleepiness Scale (\u22120.7; p\u2005=\u2005.017), Fatigue Severity Scale (\u22123.0; p\u2005=\u2005.022), Insomnia Severity Index (\u22121.8; p\u2005&amp;lt;\u2005.001), and Pittsburgh Sleep Quality Index (\u22120.7; p\u2005=\u2005.032), also showed significant improvements. Although the intervention did not significantly alter glycolipid metabolism, ventricular function, or cardiac structural remodeling, it achieved a significant reduction in systolic (\u22124.5 mmHg; p\u2005=\u2005.004) and diastolic blood pressure (BP; \u22123.7 mmHg; p\u2005&amp;lt;\u2005.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Community-based intervention for previously undiagnosed OSA in the general population yielded improvements in health-related quality of life, sleep-related symptoms, and BP. However, engagement in the intervention program was low.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trial Registration<\/jats:title>\n                  <jats:p>\u201cCommunity Intervention Trial for OSA\u201d;<\/jats:p>\n                  <jats:p>URL: https:\/\/www.chictr.org.cn\/showprojEN.html?proj=144927;<\/jats:p>\n                  <jats:p>Trial identification number: ChiCTR2100054800.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleep\/zsae132","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T15:01:24Z","timestamp":1718895684000},"source":"Crossref","is-referenced-by-count":3,"title":["Community-based intervention for obstructive sleep apnea in the general population: a randomized controlled trial"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0840-3600","authenticated-orcid":false,"given":"Longlong","family":"Wang","sequence":"first","affiliation":[{"name":"Sleep Center, Division I, Department of Geriatric Respiratory, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University; Guangdong Provincial Geriatrics Institute , Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8076-0338","authenticated-orcid":false,"given":"Qiong","family":"Ou","sequence":"additional","affiliation":[{"name":"Sleep Center, Division I, Department of Geriatric Respiratory, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University; Guangdong Provincial Geriatrics Institute , Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4535-8941","authenticated-orcid":false,"given":"Guangliang","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, School of Basic Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixin","family":"Zhan","sequence":"additional","affiliation":[{"name":"Sleep Center, Division I, Department of Geriatric Respiratory, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University; Guangdong Provincial Geriatrics Institute , Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, People\u2019s Hospital of Chenghai , Shantou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuqiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, People\u2019s Hospital of Chenghai , Shantou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfei","family":"Li","sequence":"additional","affiliation":[{"name":"Special Wards and Geriatrics Department, Shantou Central Hospital , Shantou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibin","family":"Liu","sequence":"additional","affiliation":[{"name":"Health Management Center, Shantou Central Hospital , Shantou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuejun","family":"Xu","sequence":"additional","affiliation":[{"name":"Health Management Center, Shantou Central Hospital , Shantou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Health Management Center, Shantou Central Hospital , Shantou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weili","family":"Chen","sequence":"additional","affiliation":[{"name":"Health Management Center, Shantou Central Hospital , Shantou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"issue":"8","key":"2024090905512840800_CIT0001","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S2213-2600(19)30198-5","article-title":"Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis","volume":"7","author":"Benjafield","year":"2019","journal-title":"Lancet Respir Med"},{"issue":"6","key":"2024090905512840800_CIT0002","first-page":"877","article-title":"Racial\/ethnic 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