{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:26:20Z","timestamp":1792452380789,"version":"4.5.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100006424","name":"F\u00e9d\u00e9ration pour la Recherche sur le Cerveau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006424","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alteration of motor control during rapid eye movements (REM) sleep has been extensively described in sleep disorders, in particular in isolated REM sleep behavior disorder (iRBD) and narcolepsy type 1 (NT1). NT1 is caused by the loss of orexin\/hypocretin (ORX) neurons. Unlike in iRBD, the RBD comorbid symptoms of NT1 are not associated with alpha-synucleinopathies. To determine whether the chronic absence of ORX neuropeptides is sufficient to induce RBD symptoms, we analyzed during REM sleep the EMG signal of the prepro-hypocretin knockout mice (ORX\u2212\/\u2212), a recognized mouse model of NT1. Then, we evaluated the severity of motor alterations by comparing the EMG data of ORX\u2212\/\u2212 mice to those of mice with a targeted suppression of the sublaterodorsal glutamatergic neurotransmission, a recognized rodent model of iRBD. We found a significant alteration of tonic and phasic components of EMG during REM sleep in ORX\u2212\/\u2212 mice, with more phasic events and more REM sleep episodes without atonia compared to the control wild-type mice. However, these phasic events were fewer, shorter, and less complex in ORX\u2212\/\u2212 mice compared to the RBD-like ORX\u2212\/\u2212 mice. We thus show that ORX deficiency, as seen in NT1, is sufficient to impair muscle atonia during REM sleep with a moderate severity of alteration as compared to isolated RBD mice. As described in NT1 patients, we report a major interindividual variability in the severity and frequency of RBD symptoms in ORX-deficient mice.<\/jats:p>","DOI":"10.1093\/sleep\/zsae178","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T21:09:31Z","timestamp":1723237771000},"source":"Crossref","is-referenced-by-count":8,"title":["Major alteration of motor control during rapid eye movements sleep in mice models of sleep disorders"],"prefix":"10.1093","volume":"47","author":[{"given":"Maxime","family":"Grenot","sequence":"first","affiliation":[{"name":"Universit\u00e9 Claude Bernard Lyon 1"},{"name":"CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL UMR5292, U1028, SLEEP team , Bron ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Roman","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Claude Bernard Lyon 1"},{"name":"CNRS, INSERM, Centre de Recherche en Neurosciences 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