{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:19:59Z","timestamp":1790806799100,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T00:00:00Z","timestamp":1723939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>The role of actigraphy in central disorders of hypersomnolence (CDH) is expanding but evidence of reliability with polysomnography (PSG) is scarce and provided only during nighttime. We explored the agreement between actigraphy and continuous 24-hour PSG at CDH diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Forty-four consecutive drug-na\u00efve patients (28 narcolepsy and 16 idiopathic hypersomnia [IH]) underwent actigraphy during 24 hours of free-running PSG, during multiple sleep latency test (MSLT) and 13 of them also during maintenance of wakefulness test (MWT). Daytime and nighttime sleep features and MSLT and MWT mean sleep latencies (mSL) were estimated with the actigraphic algorithms by Cole-Kripke (CK), Sadeh (Sad), and University of California San Diego (UCSD). Agreement to corresponding PSG measures was assessed with Bland\u2013Altman plots.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Nighttime-total sleep time (TST) in narcolepsy was significantly underestimated with CK (bias 27.8 minutes, 95% CI 13.7 to 41.9) and Sad (bias 56.7 minutes, 95% CI 38.8\/74.5). Daytime-TST was overestimated in IH and narcolepsy with all algorithms (CK: bias \u221242.2, 95% CI \u221267\/\u221217.4; Sad: bias \u221230.2 minutes, 95% CI \u221252.7\/\u22127.7; UCSD bias \u221286.9 minutes, 95% CI \u2212118.2\/\u221255.6). 24-hour-TST was overestimated by CK and UCSD in IH (CK: bias \u221258.5 minutes, 95% CI \u2212105.5\/\u221211.5; UCSD: bias \u2212118.8 minutes, 95% CI \u2212172.5\/\u221265), and by UCSD in narcolepsy (bias \u221268.8 minutes, 95% CI \u2212109.3\/\u221238.2). In the entire cohort, actigraphy overestimated MSLT mSL but not MWT mSL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Conventional actigraphic algorithms overestimate 24-hour TST in IH and underestimate nighttime TST in narcolepsy. These discrepancies call for the cautious application of actigraphy in the diagnostic process of CDH and the development of new quantitative signal analysis approaches.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleep\/zsae189","type":"journal-article","created":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T04:59:25Z","timestamp":1723957165000},"source":"Crossref","is-referenced-by-count":16,"title":["The actigraphic evaluation of daytime sleep in central disorders of hypersomnolence: comparison with polysomnography"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9756-6470","authenticated-orcid":false,"given":"Francesco","family":"Biscarini","sequence":"first","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna , Bologna ,","place":["Italy"]},{"name":"UOC Clinica Neurologica, IRCCS Istituto delle Scienze Neurologiche di Bologna , Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Vandi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna , Bologna ,","place":["Italy"]},{"name":"UOC Clinica Neurologica, IRCCS Istituto delle Scienze Neurologiche di Bologna , Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Riccio","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna , Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Raggini","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna , Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Neccia","sequence":"additional","affiliation":[{"name":"UOC Clinica Neurologica, IRCCS Istituto delle Scienze Neurologiche di Bologna , Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Plazzi","sequence":"additional","affiliation":[{"name":"UOC Clinica Neurologica, IRCCS Istituto delle Scienze Neurologiche di Bologna , Bologna ,","place":["Italy"]},{"name":"Department of Biomedical, Metabolic and Neuroscience, University of Modena and Reggio Emilia , Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Pizza","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna , Bologna ,","place":["Italy"]},{"name":"UOC Clinica Neurologica, IRCCS Istituto delle Scienze Neurologiche di Bologna , Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,18]]},"reference":[{"key":"2024121108201941500_CIT0001","volume-title":"International Classification of Sleep Disorders, Third Edition, Text Revision (ICSD-3-TR)","author":"American Academy of Sleep Medicine","year":"2023"},{"issue":"6","key":"2024121108201941500_CIT0002","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1093\/sleep\/32.6.753","article-title":"Idiopathic hypersomnia with and without long sleep time: a controlled series of 75 patients","volume":"32","author":"Vernet","year":"2009","journal-title":"Sleep."},{"issue":"1","key":"2024121108201941500_CIT0003","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1093\/sleep\/28.1.123","article-title":"The clinical use of the MSLT and MWT","volume":"28","author":"Arand","year":"2005","journal-title":"Sleep."},{"issue":"4","key":"2024121108201941500_CIT0004","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.smrv.2010.10.001","article-title":"The role and validity of actigraphy in sleep medicine: an update","volume":"15","author":"Sadeh","year":"2011","journal-title":"Sleep Med Rev."},{"issue":"7","key":"2024121108201941500_CIT0005","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.5664\/jcsm.7228","article-title":"Use of actigraphy for the evaluation of sleep disorders and circadian rhythm sleep-wake disorders: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment","volume":"14","author":"Smith","year":"2018","journal-title":"J Clin Sleep Med."},{"issue":"6","key":"2024121108201941500_CIT0006","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.5665\/sleep.5842","article-title":"Circadian rest-activity rhythm in pediatric type 1 narcolepsy","volume":"39","author":"Filardi","year":"2016","journal-title":"Sleep."},{"issue":"5","key":"2024121108201941500_CIT0007","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.5665\/sleep.5750","article-title":"Hypocretin-1 levels associate with fragmented sleep in patients with narcolepsy type 1","volume":"39","author":"Alakuijala","year":"2016","journal-title":"Sleep."},{"key":"2024121108201941500_CIT0008","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.sleep.2018.07.024","article-title":"Using actigraphy to assess sleep and wake rhythms of narcolepsy type 1 patients: a comparison with primary insomniacs and healthy controls","volume":"52","author":"Leger","year":"2018","journal-title":"Sleep Med."},{"issue":"1","key":"2024121108201941500_CIT0009","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.sleep.2014.08.017","article-title":"Actigraphic assessment of sleep\/wake behavior in central disorders of hypersomnolence","volume":"16","author":"Filardi","year":"2015","journal-title":"Sleep Med."},{"issue":"6","key":"2024121108201941500_CIT0010","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy050","article-title":"In-field assessment of sodium oxybate effect in pediatric type 1 narcolepsy: an actigraphic study","volume":"41","author":"Filardi","year":"2018","journal-title":"Sleep."},{"key":"2024121108201941500_CIT0011","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.sleep.2021.06.033","article-title":"Diagnostic value of actigraphy in hypersomnolence disorders","volume":"85","author":"Torstensen","year":"2021","journal-title":"Sleep Med."},{"key":"2024121108201941500_CIT0012","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fneur.2021.629709","article-title":"Accuracy of actigraphy compared to concomitant ambulatory polysomnography in narcolepsy and other sleep disorders","volume-title":"Front Neurol","author":"Alakuijala","year":"2021"},{"issue":"4","key":"2024121108201941500_CIT0013","doi-asserted-by":"publisher","first-page":"597","DOI":"10.5664\/jcsm.7722","article-title":"Optimizing actigraphic estimation of sleep duration in suspected idiopathic hypersomnia","volume":"15","author":"Cook","year":"2019","journal-title":"J Clin Sleep Med"},{"issue":"5","key":"2024121108201941500_CIT0014","doi-asserted-by":"publisher","first-page":"841","DOI":"10.5664\/jcsm.7120","article-title":"Ability of the multisensory jawbone UP3 to quantify and classify sleep in patients with suspected central disorders of hypersomnolence: a comparison against polysomnography and actigraphy","volume":"14","author":"Cook","year":"2018","journal-title":"J Clin Sleep Med"},{"issue":"1","key":"2024121108201941500_CIT0015","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/J.JCLINEPI.2010.03.002","article-title":"Guidelines for Reporting Reliability and Agreement Studies (GRRAS) were proposed","volume":"64","author":"Kottner","year":"2011","journal-title":"J Clin Epidemiol"},{"issue":"1","key":"2024121108201941500_CIT0016","doi-asserted-by":"publisher","first-page":"e207815","DOI":"10.1212\/WNL.0000000000207815","article-title":"Role of daytime continuous polysomnography in the diagnosis of pediatric narcolepsy type 1","volume":"102","author":"Pizza","year":"2024","journal-title":"Neurology."},{"issue":"1","key":"2024121108201941500_CIT0017","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1365-2869.2012.01032.x","article-title":"Daytime continuous polysomnography predicts MSLT results in hypersomnias of central origin","volume":"22","author":"Pizza","year":"2013","journal-title":"J Sleep Res."},{"issue":"1","key":"2024121108201941500_CIT0018","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/sleep\/28.1.113","article-title":"Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test","volume":"28","author":"Littner","year":"2005","journal-title":"Sleep."},{"issue":"12","key":"2024121108201941500_CIT0019","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.5664\/jcsm.9620","article-title":"Recommended protocols for the Multiple Sleep Latency Test and Maintenance of Wakefulness Test in adults: guidance from the American Academy of Sleep Medicine","volume":"17","author":"Krahn","year":"2021","journal-title":"J Clin Sleep Med"},{"issue":"5","key":"2024121108201941500_CIT0020","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1093\/sleep\/15.5.461","article-title":"Automatic sleep\/wake identification from wrist activity","volume":"15","author":"Cole","year":"1992","journal-title":"Sleep."},{"issue":"3","key":"2024121108201941500_CIT0021","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1093\/sleep\/17.3.201","article-title":"Activity-based sleep-wake identification: an empirical test of methodological issues","volume":"17","author":"Sadeh","year":"1994","journal-title":"Sleep."},{"key":"2024121108201941500_CIT0022","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/s0031-9384(00)00355-3","article-title":"Sleep detection with an accelerometer actigraph: comparisons with polysomnography","volume-title":"Physiol Behav","author":"Jean-louis","year":"2001"},{"key":"2024121108201941500_CIT0023","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.smrv.2019.05.001","article-title":"Agreement between actigraphic and polysomnographic measures of sleep in adults with and without chronic conditions: a systematic review and meta-analysis","volume":"46","author":"Conley","year":"2019","journal-title":"Sleep Med Rev."},{"issue":"2","key":"2024121108201941500_CIT0024","doi-asserted-by":"publisher","first-page":"617","DOI":"10.5664\/jcsm.9682","article-title":"Idiopathic hypersomnia severity scale to better quantify symptoms severity and their consequences in idiopathic hypersomnia","volume":"18","author":"Rassu","year":"2022","journal-title":"J Clin Sleep Med."},{"issue":"3","key":"2024121108201941500_CIT0025","doi-asserted-by":"publisher","first-page":"341","DOI":"10.4088\/jcp.10m06176blu","article-title":"Comorbidity patterns of anxiety and depressive disorders in a large cohort study: the Netherlands Study of Depression and Anxiety (NESDA)","volume":"72","author":"Lamers","year":"2011","journal-title":"J Clin Psychiatry."},{"issue":"20","key":"2024121108201941500_CIT0026","doi-asserted-by":"publisher","first-page":"e2755","DOI":"10.1212\/WNL.0000000000010737","article-title":"Depression and suicidal thoughts in untreated and treated narcolepsy: systematic analysis","volume":"95","author":"Barateau","year":"2020","journal-title":"Neurology."},{"issue":"7","key":"2024121108201941500_CIT0027","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1017\/S0033291722000903","article-title":"Actigraphically measured psychomotor slowing in depression: systematic review and meta-analysis","volume":"52","author":"W\u00fcthrich","year":"2022","journal-title":"Psychol Med."},{"issue":"1-2","key":"2024121108201941500_CIT0028","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/s0031-9384(00)00228-6","article-title":"Sleep estimation from wrist activity in patients with major depression","volume":"70","author":"Jean-Louis","year":"2000","journal-title":"Physiol Behav."},{"key":"2024121108201941500_CIT0029","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.jad.2017.04.030","article-title":"Utility of the Fitbit Flex to evaluate sleep in major depressive disorder: a comparison against polysomnography and wrist-worn actigraphy","volume":"217","author":"Cook","year":"2017","journal-title":"J Affect Disord."},{"key":"2024121108201941500_CIT0030","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.smrv.2016.08.005","article-title":"Waking up is the hardest thing I do all day: sleep inertia and sleep drunkenness","volume":"35","author":"Trotti","year":"2017","journal-title":"Sleep Med Rev."},{"issue":"3","key":"2024121108201941500_CIT0031","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1111\/j.1365-2869.2007.00601.x","article-title":"Periodic leg movements during sleep and wakefulness in narcolepsy","volume":"16","author":"Dauvilliers","year":"2007","journal-title":"J Sleep Res."},{"issue":"7","key":"2024121108201941500_CIT0032","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.sleep.2010.12.016","article-title":"Overnight distribution and motor characteristics of REM sleep behaviour disorder episodes in patients with narcolepsy-cataplexy","volume":"12","author":"Cipolli","year":"2011","journal-title":"Sleep Med."},{"issue":"1","key":"2024121108201941500_CIT0033","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.sleep.2009.02.009","article-title":"Obstructive sleep apnea in narcolepsy","volume":"11","author":"Sansa","year":"2010","journal-title":"Sleep Med."},{"issue":"6","key":"2024121108201941500_CIT0034","doi-asserted-by":"publisher","first-page":"919","DOI":"10.5665\/sleep.4740","article-title":"An evidence-based analysis of the association between periodic leg movements during sleep and arousals in restless legs syndrome","volume":"38","author":"Ferri","year":"2015","journal-title":"Sleep."},{"issue":"1","key":"2024121108201941500_CIT0035","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s11325-012-0689-z","article-title":"Comparison of three actigraphic algorithms used to evaluate sleep in patients with obstructive sleep apnea","volume":"17","author":"Kim","year":"2013","journal-title":"Sleep Breath."},{"issue":"10","key":"2024121108201941500_CIT0036","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa066","article-title":"Defining disrupted nighttime sleep and assessing its diagnostic utility for pediatric narcolepsy type 1","volume":"43","author":"Maski","year":"2020","journal-title":"Sleep."},{"issue":"1","key":"2024121108201941500_CIT0037","doi-asserted-by":"publisher","first-page":"5229","DOI":"10.1038\/s41467-018-07229-3","article-title":"Neural network analysis of sleep stages enables efficient diagnosis of narcolepsy","volume":"9","author":"Stephansen","year":"2018","journal-title":"Nat Commun"},{"issue":"8","key":"2024121108201941500_CIT0038","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.5665\/sleep.4908","article-title":"Nocturnal sleep dynamics identify narcolepsy type 1","volume":"38","author":"Pizza","year":"2015","journal-title":"Sleep."},{"issue":"2","key":"2024121108201941500_CIT0039","doi-asserted-by":"publisher","first-page":"e250","DOI":"10.1212\/WNL.0000000000011157","article-title":"REM sleep behavior disorder in children with type 1 narcolepsy treated with sodium oxybate","volume":"96","author":"Antelmi","year":"2021","journal-title":"Neurology."},{"issue":"4","key":"2024121108201941500_CIT0040","doi-asserted-by":"publisher","first-page":"e12789","DOI":"10.1111\/jsr.12789","article-title":"Ability of the fitbit alta HR to quantify and classify sleep in patients with suspected central disorders of hypersomnolence: a comparison against polysomnography","volume":"28","author":"Cook","year":"2019","journal-title":"J Sleep Res."},{"key":"2024121108201941500_CIT0041","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.2147\/NSS.S373107","article-title":"Actigraphy-based sleep detection: validation with polysomnography and comparison of performance for nighttime and daytime sleep during simulated shift work","volume":"14","author":"Gao","year":"2022","journal-title":"Nat Sci Sleep"}],"container-title":["SLEEP"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/sleep\/advance-article-pdf\/doi\/10.1093\/sleep\/zsae189\/59191699\/zsae189.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/sleep\/article-pdf\/47\/12\/zsae189\/60774128\/zsae189.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/sleep\/article-pdf\/47\/12\/zsae189\/60774128\/zsae189.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T08:25:32Z","timestamp":1733905532000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/sleep\/article\/doi\/10.1093\/sleep\/zsae189\/7735366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,18]]},"references-count":41,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,8,18]]},"published-print":{"date-parts":[[2024,12,11]]}},"URL":"https:\/\/doi.org\/10.1093\/sleep\/zsae189","relation":{},"ISSN":["0161-8105","1550-9109"],"issn-type":[{"value":"0161-8105","type":"print"},{"value":"1550-9109","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,12]]},"published":{"date-parts":[[2024,8,18]]},"article-number":"zsae189"}}