{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:53:45Z","timestamp":1789480425428,"version":"build-2803163510"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>Obstructive sleep apnea (OSA) may increase the risk of dementia. A potential pathway for this risk is through cerebral small vessel disease (CSVD). In the context of an existing randomized trial of aspirin for primary prevention, we aimed to investigate OSA\u2019s impact on CSVD imaging measures and explore whether aspirin effects these measures over 3 years that differ in the presence or absence of OSA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A substudy of the aspirin in reducing events in the elderly (ASPREE) randomized placebo-controlled trial of low-dose aspirin. Community-dwelling participants aged 70 years and above, without cognitive impairment, cardiovascular disease, or known OSA completed an unattended limited-channel sleep study that calculated the oxygen desaturation index and apnea\u2013hypopnea index. At baseline and 3 years later, volumes of white matter hyperintensities (WMH) and silent brain infarctions (SBI) were measured on 1.5 Tesla brain magnetic resonance imaging, and retinal vessel calibers were calculated from retinal vascular imaging.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Mild and moderate\/severe OSA was detected in 48.9% and 29.9%, respectively, of the 311 participants, who had a mean age of 73.7 years (SD 3.4 years), 38.6% female. OSA of any severity was not associated with WMH volumes, SBI, nor retinal vessel calibers at baseline, nor with change in these measures in the 277 participants with repeated measures acquired after 3 years. OSA of any severity did not interact with aspirin on change in these measures over 3 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In healthy older adults undiagnosed OSA was not associated with retinal vascular calibers and neuroimaging measures of CSVD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trial Information<\/jats:title>\n                  <jats:p>ASPREE trial has registration with the International Standard Randomized Controlled Trial Number (ISRCTN) www.isrctn.com, ISRCTN83772183 and with www.clinicaltrials.gov, NCT01038583. SNORE-ASA has registration with the Australian New Zealand Clinical Trials Registry (ANZCTR) at www.anzctr.org.au, ACTRN12612000891820.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleep\/zsae204","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T10:38:06Z","timestamp":1726828686000},"source":"Crossref","is-referenced-by-count":6,"title":["Obstructive sleep apnea and cerebral small vessel disease in community-based older people: an aspirin in reducing events in the elderly imaging substudy"],"prefix":"10.1093","volume":"48","author":[{"given":"Stephanie A","family":"Ward","sequence":"first","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC ,","place":["Australia"]},{"name":"Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales , Kensington, NSW ,","place":["Australia"]},{"name":"Department of Geriatric Medicine, Prince of Wales Hospital , Randwick, NSW ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsdon","family":"Storey","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T","family":"Naughton","sequence":"additional","affiliation":[{"name":"The Department of Respiratory Medicine, Alfred Hospital, and The Central Clinical School, Monash University , Melbourne, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2126-1045","authenticated-orcid":false,"given":"Rory","family":"Wolfe","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garun S","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Lung, Sleep, Allergy and Immunology, Monash Health , Clayton, VIC, Australia"},{"name":"School of Clinical Sciences, Monash University , Clayton VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Central Clinical School, Monash University , Melbourne, VIC ,","place":["Australia"]},{"name":"Department of Radiology, Alfred Health , Melbourne, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Division of Public Health, Department of Social Medicine, Graduate School of Medicine, Osaka University , Suita-City ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter P","family":"Abhayaratna","sequence":"additional","affiliation":[{"name":"College of Health and Medicine, Australian National University , Canberra, ACT ,","place":["Australia"]},{"name":"Academic Unit of Internal Medicine, Canberra Hospital , Garran, ACT ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9380-6075","authenticated-orcid":false,"given":"Katherine L","family":"Webb","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergal J","family":"O\u2019Donoghue","sequence":"additional","affiliation":[{"name":"Institute for Breathing and Sleep, Austin Health , Heidelberg, VIC ,","place":["Australia"]},{"name":"Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne , Parkville, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danijela","family":"Gasevic","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC ,","place":["Australia"]},{"name":"Centre for Usher Institute, University of Edinburgh , Teviot Place ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel P","family":"Stocks","sequence":"additional","affiliation":[{"name":"Discipline of General Practice, Adelaide Medical School, University of Adelaide , Adelaide, SA ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth E","family":"Trevaks","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liubov D","family":"Robman","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC ,","place":["Australia"]},{"name":"Centre for Eye Research Australia, University of Melbourne , East Melbourne, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Kolbe","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Central Clinical School, Monash University , Melbourne, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharyn M","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne G","family":"Orchard","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8448-1264","authenticated-orcid":false,"given":"Tien Y","family":"Wong","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Beijing Tsinghua Changgang Hospital, Tsinghua Medicine, Tsinghua University , Beijing ,","place":["China"]},{"name":"Singapore Eye Research Institute, Singapore National Eye Center ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1049-5129","authenticated-orcid":false,"given":"John J","family":"McNeil","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M","family":"Reid","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC ,","place":["Australia"]},{"name":"Curtin School of Population Health, Curtin University , Bentley, Perth, WA ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Sinclair","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Central Clinical School, Monash University , Melbourne, VIC ,","place":["Australia"]},{"name":"Department of Radiology, Alfred Health , Melbourne, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1249-6149","authenticated-orcid":false,"given":"Robyn L","family":"Woods","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"issue":"10248","key":"2025021005512589500_CIT0001","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet."},{"issue":"4","key":"2025021005512589500_CIT0002","doi-asserted-by":"publisher","first-page":"2101649","DOI":"10.1183\/13993003.01649-2021","article-title":"Sleep Apnoea in the elderly: a great challenge for the future","volume":"59","author":"Osorio","year":"2021","journal-title":"Eur Respir J."},{"key":"2025021005512589500_CIT0003","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.smrv.2017.06.010","article-title":"Sleep disturbances increase the risk of dementia: a systematic review and meta-analysis","volume":"40","author":"Shi","year":"2018","journal-title":"Sleep Med Rev."},{"issue":"1","key":"2025021005512589500_CIT0004","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11325-021-02382-4","article-title":"Endothelial Dysfunction in obstructive sleep apnea patients","volume":"26","author":"Haranczyk","year":"2022","journal-title":"Sleep Breath."},{"issue":"4","key":"2025021005512589500_CIT0005","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1007\/s11325-020-02021-4","article-title":"Increased platelet activation in sleep apnea subjects with intermittent hypoxemia","volume":"24","author":"Krieger","year":"2020","journal-title":"Sleep Breath."},{"issue":"9","key":"2025021005512589500_CIT0006","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.5665\/sleep.4986","article-title":"Regional cerebral blood flow during wakeful rest in older subjects with mild to severe obstructive sleep apnea","volume":"38","author":"Baril","year":"2015","journal-title":"Sleep."},{"issue":"5","key":"2025021005512589500_CIT0007","doi-asserted-by":"publisher","first-page":"763","DOI":"10.5665\/sleep.2644","article-title":"Vascular inflammation and sleep disordered breathing in a community-based cohort","volume":"36","author":"Chami","year":"2013","journal-title":"Sleep."},{"issue":"8","key":"2025021005512589500_CIT0008","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/s41569-023-00846-6","article-title":"Obstructive sleep apnoea heterogeneity and cardiovascular disease","volume":"20","author":"Redline","year":"2023","journal-title":"Nat Rev Cardiol."},{"issue":"24","key":"2025021005512589500_CIT0009","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1212\/WNL.0000000000007654","article-title":"CNS small vessel disease: a clinical review","volume":"92","author":"Cannistraro","year":"2019","journal-title":"Neurology."},{"issue":"8","key":"2025021005512589500_CIT0010","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/S1474-4422(13)70124-8","article-title":"STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1). Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration","volume":"12","author":"Wardlaw","year":"2013","journal-title":"Lancet Neurol."},{"issue":"7","key":"2025021005512589500_CIT0011","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s11910-015-0561-1","article-title":"Retinal vascular changes are a marker for cerebral vascular diseases","volume":"15","author":"Moss","year":"2015","journal-title":"Curr Neurol Neurosci Rep."},{"issue":"pt 7","key":"2025021005512589500_CIT0012","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1093\/brain\/awq127","article-title":"Retinal microvascular abnormalities and subclinical magnetic resonance imaging brain infarct: a prospective study","volume":"133","author":"Cheung","year":"2010","journal-title":"Brain."},{"key":"2025021005512589500_CIT0013","doi-asserted-by":"publisher","first-page":"101763","DOI":"10.1016\/j.smrv.2023.101763","article-title":"Obstructive sleep apnea is associated with markers of cerebral small vessel disease in a dose-response manner: a systematic review and meta-analysis","volume":"68","author":"Lee","year":"2023","journal-title":"Sleep Med Rev."},{"issue":"4","key":"2025021005512589500_CIT0014","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz264","article-title":"Association of obstructive sleep apnea and cerebral small vessel disease: a systematic review and meta-analysis","volume":"43","author":"Huang","year":"2020","journal-title":"Sleep."},{"key":"2025021005512589500_CIT0015","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ajo.2017.07.012","article-title":"Quantitative retinal vascular changes in obstructive sleep apnea","volume":"182","author":"Tong","year":"2017","journal-title":"Am J Ophthalmol."},{"key":"2025021005512589500_CIT0016","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3390\/futurepharmacol3010011","article-title":"Aspirin therapy, cognitive impairment, and dementia - a review","volume":"3","author":"Thong","year":"2023","journal-title":"Future Pharmacol."},{"issue":"2","key":"2025021005512589500_CIT0017","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cct.2013.09.014","article-title":"Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial","volume":"36","author":"ASPREE Investigator Group","year":"2013","journal-title":"Contemp Clin Trials."},{"issue":"16","key":"2025021005512589500_CIT0018","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1056\/NEJMoa1800722","article-title":"Effect of aspirin on disability-free survival in the healthy elderly","volume":"379","author":"McNeil","year":"2018","journal-title":"N Engl J Med."},{"key":"2025021005512589500_CIT0019","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.cct.2017.10.016","article-title":"The Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnoea- rationale and methodology of the SNORE-ASA study","volume":"64","author":"Ward","year":"2018","journal-title":"Contemp Clin Trials."},{"issue":"4","key":"2025021005512589500_CIT0020","doi-asserted-by":"crossref","first-page":"387","DOI":"10.5664\/jcsm.26861","article-title":"Validation of the ApneaLink for the screening of sleep apnea: a novel and simple single-channel recording device","volume":"3","author":"Erman","year":"2007","journal-title":"J Clin Sleep Med."},{"key":"2025021005512589500_CIT0021","volume-title":"Bayesian inference for structured additive regression models for large-scale problems with applications to medical imaging","author":"Paul Schmidt","year":"2017"},{"issue":"12","key":"2025021005512589500_CIT0022","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1016\/s0161-6420(99)90525-0","article-title":"Methods for evaluation of retinal microvascular abnormalities associated with hypertension\/sclerosis in the Atherosclerosis Risk in Communities Study","volume":"106","author":"Hubbard","year":"1999","journal-title":"Ophthalmology."},{"key":"2025021005512589500_CIT0023","doi-asserted-by":"publisher","first-page":"1096808","DOI":"10.3389\/fnagi.2023.1096808","article-title":"Value of white matter hyperintensity volume and total white matter volume for evaluating cognitive impairment in patients with cerebral small-vessel disease","volume":"15","author":"Zhang","year":"2023","journal-title":"Front Aging Neurosci."},{"issue":"4","key":"2025021005512589500_CIT0024","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/S2213-2600(15)00043-0","article-title":"Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study","volume":"3","author":"Heinzer","year":"2015","journal-title":"Lancet Respir Med."},{"issue":"2","key":"2025021005512589500_CIT0025","doi-asserted-by":"publisher","first-page":"e164","DOI":"10.1212\/WNL.0000000000207378","article-title":"Longitudinal relationships of white matter hyperintensities and alzheimer disease biomarkers across the adult life span","volume":"101","author":"Luo","year":"2023","journal-title":"Neurology."},{"issue":"3","key":"2025021005512589500_CIT0026","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1212\/01.wnl.0000251302.55202.73","article-title":"Progression of white matter hyperintensities in elderly individuals over 3 years","volume":"68","author":"Sachdev","year":"2007","journal-title":"Neurology."},{"issue":"8","key":"2025021005512589500_CIT0027","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1097\/HJH.0000000000001380","article-title":"Retinal vessel metrics: normative data and their use in systemic hypertension: results from the Gutenberg Health Study","volume":"35","author":"Ponto","year":"2017","journal-title":"J Hypertens."},{"issue":"5","key":"2025021005512589500_CIT0028","doi-asserted-by":"publisher","first-page":"322","DOI":"10.3109\/09286586.2012.702258","article-title":"Correlation and reproducibility of retinal vascular geometric measurements for stereoscopic retinal images of the same eyes","volume":"19","author":"Sasongko","year":"2012","journal-title":"Ophthalmic Epidemiol."},{"issue":"51","key":"2025021005512589500_CIT0029","doi-asserted-by":"publisher","first-page":"e28229","DOI":"10.1097\/MD.0000000000028229","article-title":"Risk factors of cerebral small vessel disease: a systematic review and meta-analysis","volume":"100","author":"Wang","year":"2021","journal-title":"Medicine (Baltim)."},{"key":"2025021005512589500_CIT0030","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.sleep.2019.11.1262","article-title":"Impact of obstructive sleep apnea on silent cerebral small vessel disease: a systematic review and meta-analysis","volume":"68","author":"Chokesuwattanaskul","year":"2020","journal-title":"Sleep Med."},{"issue":"8","key":"2025021005512589500_CIT0031","doi-asserted-by":"publisher","first-page":"e1000132","DOI":"10.1371\/journal.pmed.1000132","article-title":"Sleep-disordered breathing and mortality: a prospective cohort study","volume":"6","author":"Punjabi","year":"2009","journal-title":"PLoS Med."},{"issue":"5","key":"2025021005512589500_CIT0032","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1513\/AnnalsATS.202006-696FR","article-title":"Excessive daytime sleepiness in obstructive sleep apnea. Mechanisms and clinical management","volume":"18","author":"Lal","year":"2021","journal-title":"Ann Am Thorac Soc."},{"issue":"1","key":"2025021005512589500_CIT0033","doi-asserted-by":"publisher","first-page":"e12553","DOI":"10.1002\/dad2.12553","article-title":"Investigating the relationship between sleep disturbances and white matter hyperintensities in older adults on the Alzheimer\u2019s disease spectrum","volume":"16","author":"Kamal","year":"2024","journal-title":"Alzheimers Dement (Amst)"},{"issue":"11","key":"2025021005512589500_CIT0034","doi-asserted-by":"publisher","first-page":"5465","DOI":"10.1002\/hbm.23739","article-title":"Associations between self-reported sleep quality and white matter in community-dwelling older adults: a prospective cohort study","volume":"38","author":"Sexton","year":"2017","journal-title":"Hum Brain Mapp."},{"issue":"9","key":"2025021005512589500_CIT0035","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1111\/resp.14279","article-title":"Sleep-disordered breathing was associated with lower health-related quality of life and cognitive function in a cross-sectional study of older adults","volume":"27","author":"Ward","year":"2022","journal-title":"Respirology."},{"issue":"2","key":"2025021005512589500_CIT0036","doi-asserted-by":"publisher","first-page":"e125","DOI":"10.1212\/WNL.0000000000207392","article-title":"Association of polysomnographic sleep parameters with neuroimaging biomarkers of cerebrovascular disease in older adults with sleep apnea","volume":"101","author":"Carvalho","year":"2023","journal-title":"Neurology."},{"issue":"2","key":"2025021005512589500_CIT0037","doi-asserted-by":"publisher","first-page":"427","DOI":"10.3233\/JAD-220910","article-title":"Cardiorespiratory fitness attenuates the deleterious effects of sleep apnea on cerebral Structure and Perfusion in the Wisconsin Sleep Cohort Study","volume":"95","author":"Edmunds","year":"2023","journal-title":"J Alzheimers Dis."},{"issue":"10","key":"2025021005512589500_CIT0038","doi-asserted-by":"publisher","first-page":"e2128225","DOI":"10.1001\/jamanetworkopen.2021.28225","article-title":"Association between obstructive sleep apnea and brain white matter hyperintensities in a population-based cohort in Germany","volume":"4","author":"Zacharias","year":"2021","journal-title":"JAMA Netw Open"},{"issue":"3","key":"2025021005512589500_CIT0039","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1093\/sleep\/27.3.474","article-title":"Sleep-disordered breathing and white matter disease in the brainstem in older adults","volume":"27","author":"Ding","year":"2004","journal-title":"Sleep."},{"issue":"7","key":"2025021005512589500_CIT0040","doi-asserted-by":"publisher","first-page":"e0158758","DOI":"10.1371\/journal.pone.0158758","article-title":"Sleep apnea, sleep duration and brain mri markers of cerebral vascular disease and Alzheimer\u2019s disease: The Atherosclerosis Risk in Communities Study (ARIC)","volume":"11","author":"Lutsey","year":"2016","journal-title":"PLoS One."},{"issue":"9","key":"2025021005512589500_CIT0041","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1007\/s13258-023-01402-9","article-title":"Correlation between obstructive sleep apnea and cerebral small vessel disease: a mendelian randomization study","volume":"45","author":"Wu","year":"2023","journal-title":"Genes Genomics"},{"issue":"5","key":"2025021005512589500_CIT0042","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.ophtha.2007.06.036","article-title":"Arteriolar oxygen saturation, cerebral blood flow, and retinal vessel diameters. The Rotterdam Study","volume":"115","author":"de Jong","year":"2008","journal-title":"Ophthalmology."},{"key":"2025021005512589500_CIT0043","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.atherosclerosis.2021.09.025","article-title":"The association between markers of inflammation and retinal microvascular parameters: a systematic review and meta-analysis","volume":"336","author":"Liu","year":"2021","journal-title":"Atherosclerosis."},{"issue":"1","key":"2025021005512589500_CIT0044","doi-asserted-by":"publisher","first-page":"e0279306","DOI":"10.1371\/journal.pone.0279306","article-title":"Sleep disordered breathing has minimal association with retinal microvascular diameters in a non-diabetic sleep clinic cohort","volume":"18","author":"Kairaitis","year":"2023","journal-title":"PLoS One."},{"issue":"3","key":"2025021005512589500_CIT0045","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1093\/sleep\/27.3.467","article-title":"Sleep-disordered breathing is not associated with the presence of retinal microvascular abnormalities: the Sleep Heart Health Study","volume":"27","author":"Boland","year":"2004","journal-title":"Sleep."},{"issue":"1","key":"2025021005512589500_CIT0046","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.atherosclerosis.2012.10.046","article-title":"Sleep-disordered breathing and retinal microvascular diameter","volume":"226","author":"Shankar","year":"2013","journal-title":"Atherosclerosis."},{"issue":"7","key":"2025021005512589500_CIT0047","doi-asserted-by":"publisher","first-page":"e003598","DOI":"10.1161\/JAHA.116.003598","article-title":"Sex-specific association of obstructive sleep apnea with retinal microvascular signs: The Multi-Ethnic Study of Atherosclerosis","volume":"5","author":"Lin","year":"2016","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"2025021005512589500_CIT0048","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s11325-015-1177-z","article-title":"Sleep apnea and retinal signs in cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis","volume":"20","author":"Chew","year":"2016","journal-title":"Sleep Breath."},{"issue":"1","key":"2025021005512589500_CIT0049","doi-asserted-by":"publisher","first-page":"zpae004","DOI":"10.1093\/sleepadvances\/zpae004","article-title":"Obstructive sleep apnea, nocturnal hypoxemia, and retinal microvasculature: The Atherosclerosis Risk in Communities Study","volume":"5","author":"Hoeft","year":"2024","journal-title":"Sleep Adv"},{"issue":"9678","key":"2025021005512589500_CIT0050","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1016\/S0140-6736(09)60503-1","article-title":"Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials","volume":"373","author":"Baigent","year":"2009","journal-title":"Lancet."},{"issue":"3","key":"2025021005512589500_CIT0051","doi-asserted-by":"crossref","first-page":"e320","DOI":"10.1212\/WNL.0000000000009277","article-title":"Randomized placebo-controlled trial of the effects of aspirin on dementia and cognitive decline","volume":"95","author":"Ryan","year":"2020","journal-title":"Neurology."},{"issue":"3","key":"2025021005512589500_CIT0052","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1111\/jgs.13321","article-title":"Associations between sleep-disordered breathing, nocturnal hypoxemia, and subsequent cognitive decline in older community-dwelling men: the Osteoporotic Fractures in Men Sleep Study","volume":"63","author":"Blackwell","year":"2015","journal-title":"J Am Geriatr Soc."},{"issue":"7","key":"2025021005512589500_CIT0053","doi-asserted-by":"publisher","first-page":"e2325152","DOI":"10.1001\/jamanetworkopen.2023.25152","article-title":"Sleep architectur, obstructive sleep apnea, and cognitive function in adults","volume":"6","author":"Pase","year":"2023","journal-title":"JAMA Netw Open."},{"issue":"4","key":"2025021005512589500_CIT0054","doi-asserted-by":"publisher","first-page":"2201621","DOI":"10.1183\/13993003.01621-2022","article-title":"Obstructive sleep apnoea and 5-year cognitive decline in the elderly","volume":"61","author":"Marchi","year":"2023","journal-title":"Eur Respir J."},{"issue":"6","key":"2025021005512589500_CIT0055","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1001\/jama.2011.1115","article-title":"Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women","volume":"306","author":"Yaffe","year":"2011","journal-title":"JAMA."},{"issue":"2","key":"2025021005512589500_CIT0056","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.jalz.2017.06.2269","article-title":"Sleep characteristics and risk of dementia and Alzheimer\u2019s disease: The Atherosclerosis Risk in Communities Study","volume":"14","author":"Lutsey","year":"2018","journal-title":"Alzheimers Dement"},{"issue":"6","key":"2025021005512589500_CIT0057","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1111\/resp.13728","article-title":"Advances in pathophysiology and neuroimaging: implications for sleep and dementia","volume":"25","author":"Ward","year":"2020","journal-title":"Respirology."},{"key":"2025021005512589500_CIT0058","doi-asserted-by":"publisher","first-page":"101790","DOI":"10.1016\/j.smrv.2023.101790","article-title":"The association of obstructive sleep apnea with blood and cerebrospinal fluid biomarkers of Alzheimer\u2019s dementia - a systematic review and meta-analysis","volume":"70","author":"Yeo","year":"2023","journal-title":"Sleep Med Rev."},{"issue":"1","key":"2025021005512589500_CIT0059","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer\u2019s pathological cascade","volume":"9","author":"Jack","year":"2010","journal-title":"Lancet Neurol."},{"key":"2025021005512589500_CIT0060","doi-asserted-by":"publisher","first-page":"101250","DOI":"10.1016\/j.smrv.2019.101250","article-title":"Obstructive sleep apnea, cognition and Alzheimer\u2019s disease: a systematic review integrating three decades of multidisciplinary research","volume":"50","author":"Bubu","year":"2020","journal-title":"Sleep Med Rev."},{"issue":"11","key":"2025021005512589500_CIT0061","doi-asserted-by":"publisher","first-page":"3127","DOI":"10.1111\/jgs.17933","article-title":"Overnight pulse rate variability and risk of major neurocognitive disorder in olderpatients with obstructive sleep apnea","volume":"70","author":"Sabil","year":"2022","journal-title":"J Am Geriatr Soc."},{"issue":"1","key":"2025021005512589500_CIT0062","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1177\/17474930221144911","article-title":"Cerebral small vessel disease: recent advances and future directions","volume":"18","author":"Markus","year":"2023","journal-title":"Int J Stroke"},{"issue":"7","key":"2025021005512589500_CIT0063","doi-asserted-by":"publisher","first-page":"e2222999","DOI":"10.1001\/jamanetworkopen.2022.22999","article-title":"Association of obstructive sleep apnea with white matter integrity and cognitive performance over a 4-year period in middle to late adulthood","volume":"5","author":"Lee","year":"2022","journal-title":"JAMA Netw Open"},{"key":"2025021005512589500_CIT0064","doi-asserted-by":"crossref","first-page":"1215882","DOI":"10.3389\/fneur.2023.1215882","article-title":"Altered resting-state functional connectivity patterns in late middle-aged and older adults with obstructive sleep apnea","volume":"14","author":"Martinez Villar","year":"2023","journal-title":"Front Neurol."},{"issue":"6","key":"2025021005512589500_CIT0065","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1001\/jamaneurol.2020.0311","article-title":"Association of sleep-disordered breathing with Alzheimer disease biomarkers in community-dwelling older adults: a secondary analysis of a randomized clinical trial","volume":"77","author":"Andr\u00e9","year":"2020","journal-title":"JAMA Neurol"}],"container-title":["SLEEP"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/sleep\/advance-article-pdf\/doi\/10.1093\/sleep\/zsae204\/59622180\/zsae204.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/sleep\/article-pdf\/48\/2\/zsae204\/59622180\/zsae204.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/sleep\/article-pdf\/48\/2\/zsae204\/59622180\/zsae204.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T05:51:40Z","timestamp":1739166700000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/sleep\/article\/doi\/10.1093\/sleep\/zsae204\/7762418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,12]]},"references-count":65,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,9,12]]},"published-print":{"date-parts":[[2025,2,10]]}},"URL":"https:\/\/doi.org\/10.1093\/sleep\/zsae204","relation":{},"ISSN":["0161-8105","1550-9109"],"issn-type":[{"value":"0161-8105","type":"print"},{"value":"1550-9109","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,2]]},"published":{"date-parts":[[2024,9,12]]},"article-number":"zsae204"}}