{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T11:03:20Z","timestamp":1761649400587,"version":"3.41.2"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study Objectives<\/jats:title>\n                  <jats:p>To determine any correlation between serum alpha-synuclein (\u03b1-syn) concentrations and restless legs syndrome (RLS), and to explore the impact of intravenous iron supplementation on serum \u03b1-syn levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We collected clinical data on 113 RLS patients in whom serum \u03b1-syn levels were quantified using an ELISA kit and compared to a group of 45 age-matched controls. A subset of nine RLS patients who received intravenous (IV) iron underwent pre- and post-treatment blood sampling to assess \u03b1-syn and ferritin response.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A family history of RLS was reported by 62.8% of patients, and current dopaminergic augmentation was observed in 31.0%. Low serum ferritin levels below 75 \u03bcg\/L were seen in 39.8%. Serum \u03b1-syn levels were found to be significantly decreased in RLS patients (mean: 7.7 ng\/mL) compared to controls (mean: 10.7 ng\/mL), p\u2005&amp;lt;\u2005.05. Stratification based on sex, age, and age of onset, did not reveal significant differences in \u03b1-syn levels. In nine RLS patients who received IV iron treatment, a linear correlation between fold change in \u03b1-syn and ferritin was observed (R: 0.7, p\u2005&amp;lt;\u2005.05). The temporal relation between serum \u03b1-syn and IV iron treatment showed a gradual decline of \u03b1-syn and ferritin by time correlation (p\u2005=\u2005.023, R: \u2212.739).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In our study of 113 RLS participants, serum \u03b1-syn levels were decreased in RLS patients compared to healthy controls, and increased in the nine patients who received IV iron treatment in correlation with ferritin. This correlation could suggest a mechanism for reduced dopamine transmission in RLS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sleep\/zsae217","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T14:34:53Z","timestamp":1726497293000},"source":"Crossref","is-referenced-by-count":3,"title":["Serum alpha-synuclein in restless legs syndrome"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6775-9686","authenticated-orcid":false,"given":"Aboud","family":"Tahanis","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Center for Neuroregeneration, Houston Methodist Research Institute , Houston, TX ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Hashem","sequence":"additional","affiliation":[{"name":"Department of Neurology, Methodist Neurological Institute , Houston, TX 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